ID   WHITE_LUCCU             Reviewed;         677 AA.
AC   Q05360;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Protein white;
GN   Name=W;
OS   Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Calliphoridae; Luciliinae; Lucilia.
OX   NCBI_TaxID=7375;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8933176; DOI=10.1111/j.1365-2583.1996.tb00099.x;
RA   Garcia R.L., Perkins H.D., Howells A.J.;
RT   "The structure, sequence and developmental pattern of expression of the
RT   white gene in the blowfly Lucilia cuprina.";
RL   Insect Mol. Biol. 5:251-260(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 490-584.
RX   PubMed=1971656; DOI=10.1007/bf02101889;
RA   Elizur A., Vacek A.T., Howells A.J.;
RT   "Cloning and characterization of the white and topaz eye color genes from
RT   the sheep blowfly Lucilia cuprina.";
RL   J. Mol. Evol. 30:347-358(1990).
CC   -!- FUNCTION: May be part of a membrane-spanning permease system necessary
CC       for the transport of pigment precursors into pigment cells responsible
CC       for eye color.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC       Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U38899; AAA82057.1; -; mRNA.
DR   EMBL; X53265; CAA37365.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0031409; F:pigment binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013525; ABC_2_trans.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR043926; ABCG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005284; Pigment_permease/Abcg.
DR   Pfam; PF01061; ABC2_membrane; 1.
DR   Pfam; PF19055; ABC2_membrane_7; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00955; 3a01204; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Membrane; Nucleotide-binding; Pigment; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..677
FT                   /note="Protein white"
FT                   /id="PRO_0000093383"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        456..476
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        506..526
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        534..554
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        563..583
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        647..667
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          82..330
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         119..126
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   677 AA;  75369 MW;  D16FC11C97EED51D CRC64;
     MGQEDQEFLI QEHKKRTATS VESLNNTPGT LEASAINSGF SKSYGSLVSN ESASEKLTYS
     WCNLDVFGEV HQPGSNWKQL VNRVKGVFCN ERHIPKPRKH LIKNVCGVAY PGELLAVMGS
     SGAGKTTLLN ALAFRSARGV QISPSSVRML NGHPVDAKEM QARCAYVQQD DLFIGSLTAR
     EHLIFQATVR MPRTMTQKQK LQRVDQVIQD LSLIKCQNTI IGVPGRVKGL SGGERKRLAF
     ASEALTDPPL LICDEPTSGL DSFMAASVVQ VLKKLSQRGK TVILTIHQPS SELFELFDKI
     LLMAEGRVAF LGTPVEAVDF FSFIGAQCPT NYNPADFYVQ VLAVVPGREI ESRDRISKIC
     DNFAVGKVSR EMEQNFQKIA AKTDGLQKDD ETTILYKASW FTQFRAIMWR SWISTLKEPL
     LVKVRLIQTT MVAVLIGLIF LNQPMTQVGV MNINGAIFLF LTNMTFQNVF AVINVFTSEL
     PVFMRETRSR LYRCDTYFLG KTLAELPLFL VVPFLFIAIA YPMIGLRPGI THFLSALALV
     TLVANVSTSF GYLISCASTS TSMALSVGPP LTIPFLLFGG VFLNSGSVPV YFKWLSYFSW
     FRYANEGLLI NQWADVQPGE ITCTSTNTTC PSSGXVXLET LNFRDKFTFR LYGLILLILI
     FRIAGYVAXK MRTKRKE