WHT1_CAEEL
ID WHT1_CAEEL Reviewed; 671 AA.
AC Q11180; A0A2K5ATT2; A0A2K5ATU8;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 22-APR-2020, sequence version 3.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=ABC transporter ATP-binding protein/permease wht-1;
GN Name=wht-1 {ECO:0000312|WormBase:C05D10.3a};
GN ORFNames=C05D10.3 {ECO:0000312|WormBase:C05D10.3a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=15522294; DOI=10.1016/j.jmb.2004.09.052;
RA Zhao Z., Sheps J.A., Ling V., Fang L.L., Baillie D.L.;
RT "Expression analysis of ABC transporters reveals differential functions of
RT tandemly duplicated genes in Caenorhabditis elegans.";
RL J. Mol. Biol. 344:409-417(2004).
RN [3]
RP FUNCTION.
RX PubMed=16723499; DOI=10.1091/mbc.e06-03-0192;
RA Sundaram P., Echalier B., Han W., Hull D., Timmons L.;
RT "ATP-binding cassette transporters are required for efficient RNA
RT interference in Caenorhabditis elegans.";
RL Mol. Biol. Cell 17:3678-3688(2006).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=17850180; DOI=10.1371/journal.pbio.0050237;
RA Hunt-Newbury R., Viveiros R., Johnsen R., Mah A., Anastas D., Fang L.,
RA Halfnight E., Lee D., Lin J., Lorch A., McKay S., Okada H.M., Pan J.,
RA Schulz A.K., Tu D., Wong K., Zhao Z., Alexeyenko A., Burglin T.,
RA Sonnhammer E., Schnabel R., Jones S.J., Marra M.A., Baillie D.L.,
RA Moerman D.G.;
RT "High-throughput in vivo analysis of gene expression in Caenorhabditis
RT elegans.";
RL PLoS Biol. 5:E237-E237(2007).
RN [5]
RP FUNCTION.
RX PubMed=18245353; DOI=10.1534/genetics.107.081588;
RA Sundaram P., Han W., Cohen N., Echalier B., Albin J., Timmons L.;
RT "Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-
RT 2 and mut-7.";
RL Genetics 178:801-814(2008).
CC -!- FUNCTION: Required for efficient RNA interference (RNAi)
CC (PubMed:16723499, PubMed:18245353). Plays a role in germline
CC development (PubMed:16723499, PubMed:18245353).
CC {ECO:0000269|PubMed:16723499, ECO:0000269|PubMed:18245353}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:C05D10.3a};
CC IsoId=Q11180-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:C05D10.3b};
CC IsoId=Q11180-2; Sequence=VSP_060561;
CC -!- TISSUE SPECIFICITY: Expressed in the intestine in both larvae and
CC adults (PubMed:17850180). Expressed in the gut of males
CC (PubMed:15522294). {ECO:0000269|PubMed:15522294,
CC ECO:0000269|PubMed:17850180}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryos.
CC {ECO:0000269|PubMed:15522294}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
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DR EMBL; BX284603; SPC47526.1; -; Genomic_DNA.
DR EMBL; BX284603; SPC47527.1; -; Genomic_DNA.
DR PIR; B88474; B88474.
DR AlphaFoldDB; Q11180; -.
DR SMR; Q11180; -.
DR STRING; 6239.C05D10.3; -.
DR TCDB; 3.A.1.204.3; the atp-binding cassette (abc) superfamily.
DR iPTMnet; Q11180; -.
DR EPD; Q11180; -.
DR PaxDb; Q11180; -.
DR PeptideAtlas; Q11180; -.
DR EnsemblMetazoa; C05D10.3a.1; C05D10.3a.1; WBGene00015479. [Q11180-1]
DR EnsemblMetazoa; C05D10.3b.1; C05D10.3b.1; WBGene00015479. [Q11180-2]
DR WormBase; C05D10.3a; CE52537; WBGene00015479; wht-1. [Q11180-1]
DR WormBase; C05D10.3b; CE52612; WBGene00015479; wht-1. [Q11180-2]
DR eggNOG; KOG0061; Eukaryota.
DR GeneTree; ENSGT00970000196382; -.
DR HOGENOM; CLU_000604_57_6_1; -.
DR InParanoid; Q11180; -.
DR OrthoDB; 1022017at2759; -.
DR PhylomeDB; Q11180; -.
DR PRO; PR:Q11180; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00015479; Expressed in embryo and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0035194; P:post-transcriptional gene silencing by RNA; IMP:UniProtKB.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005284; Pigment_permease/Abcg.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00955; 3a01204; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Membrane; Nucleotide-binding;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..671
FT /note="ABC transporter ATP-binding protein/permease wht-1"
FT /id="PRO_0000449487"
FT TOPO_DOM 1..408
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 409..429
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 430..451
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 452..472
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 473..497
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 498..518
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 519..525
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 526..546
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 547..550
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 551..571
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 572..644
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 645..665
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 666..671
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT DOMAIN 64..310
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 100..107
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT VAR_SEQ 1..259
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_060561"
SQ SEQUENCE 671 AA; 75210 MW; F47D515E3A4FD545 CRC64;
MHKAPISTLI LDSLFSNMML AEMMNDDQLE LLKHQQTGIQ PVVPEGCNLY WSSLNVTGPE
TKPTNFVDRF RNNMPKRRVK EILHNVSGMA ESGKLLAILG SSGAGKTTLM NVLTSRNLTN
LDVQGSILID GRRANKWKIR EMSAFVQQHD MFVGTMTARE HLQFMARLRM GDQYYSDHER
QLRVEQVLTQ MGLKKCADTV IGIPNQLKGL SCGEKKRLSF ASEILTCPKI LFCDEPTSGL
DAFMAGHVVQ ALRSLADNGM TVIITIHQPS SHVYSLFNNV CLMACGRVIY LGPGDQAVPL
FEKCGYPCPA YYNPADHLIR TLAVIDSDRA TSMKTISKIR QGFLSTDLGQ SVLAIGNANK
LRAASFVTGS DTSEKTKTFF NQDYNASFWT QFLALFWRSW LTVIRDPNLL SVRLLQILIT
AFITGIVFFQ TPVTPATIIS INGIMFNHIR NMNFMLQFPN VPVITAELPI VLRENANGVY
RTSAYFLAKN IAELPQYIIL PILYNTIVYW MSGLYPNFWN YCFASLVTIL ITNVAISISY
AVATIFANTD VAMTILPIFV VPIMAFGGFF ITFDAIPSYF KWLSSLSYFK YGYEALAINE
WDSIKVIPEC FNSSMTAFAL DSCPKNGHQV LESIDFSASH KIFDISILFG MFIGIRIIAY
VALLIRSYNN T
