ID   WHT3_CAEEL              Reviewed;         610 AA.
AC   Q09466;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=ABC transporter ATP-binding protein/permease wht-3;
DE   AltName: Full=White related ABC transporter 3;
GN   Name=wht-3; ORFNames=C16C10.12;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION.
RX   PubMed=16723499; DOI=10.1091/mbc.e06-03-0192;
RA   Sundaram P., Echalier B., Han W., Hull D., Timmons L.;
RT   "ATP-binding cassette transporters are required for efficient RNA
RT   interference in Caenorhabditis elegans.";
RL   Mol. Biol. Cell 17:3678-3688(2006).
RN   [3]
RP   FUNCTION.
RX   PubMed=18245353; DOI=10.1534/genetics.107.081588;
RA   Sundaram P., Han W., Cohen N., Echalier B., Albin J., Timmons L.;
RT   "Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-
RT   2 and mut-7.";
RL   Genetics 178:801-814(2008).
CC   -!- FUNCTION: Required for efficient RNA interference (RNAi) of pop-1
CC       indicating a role in the germline development.
CC       {ECO:0000269|PubMed:16723499, ECO:0000269|PubMed:18245353}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC       Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
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DR   EMBL; Z46787; CAA86750.1; -; Genomic_DNA.
DR   PIR; T19333; T19333.
DR   RefSeq; NP_497825.2; NM_065424.2.
DR   AlphaFoldDB; Q09466; -.
DR   SMR; Q09466; -.
DR   BioGRID; 40765; 6.
DR   STRING; 6239.C16C10.12; -.
DR   PaxDb; Q09466; -.
DR   EnsemblMetazoa; C16C10.12a.1; C16C10.12a.1; WBGene00007631.
DR   GeneID; 175528; -.
DR   CTD; 175528; -.
DR   WormBase; C16C10.12a; CE51368; WBGene00007631; wht-3.
DR   eggNOG; KOG0061; Eukaryota.
DR   HOGENOM; CLU_000604_57_6_1; -.
DR   InParanoid; Q09466; -.
DR   OMA; ALPMLCF; -.
DR   OrthoDB; 1022017at2759; -.
DR   PhylomeDB; Q09466; -.
DR   PRO; PR:Q09466; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00007631; Expressed in adult organism and 1 other tissue.
DR   ExpressionAtlas; Q09466; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013525; ABC_2_trans.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01061; ABC2_membrane; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..610
FT                   /note="ABC transporter ATP-binding protein/permease wht-3"
FT                   /id="PRO_0000093473"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        446..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        477..497
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        503..523
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        584..604
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          42..277
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         74..81
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   610 AA;  69175 MW;  CF09D591F9C73A24 CRC64;
     MPFDLLAERK RWNAGYESID TSSQKLTEVV TPITVTWENI EVKTRKKLFS KKQKQLLNRV
     SGIAKPGEMV ALMGASGAGK TTLMNVLMCR NMKGLEKNGT VKVNGTKIGK EISLISGFAQ
     QQEIFIPTLT VDEYLMIQAR LRMKANKHTR RERVDEIIEM LRLQNCRDLK IGTPGLVKGI
     SGGEARRLTF ACELLSNPSL LFADEPTSGL DSFMAASVVQ ILKNLANSGR TLIHQPTAEL
     FFQFDKIIFL SMGKTAFMGT PHESVKFFAD CGHPIPKLFN PPEWIQSKLS VIPNNETKSR
     ETIGKIIEFY EKSIIHQKSI VEIRVIATTE LPPYIENPGF FAETGALLKR ACLDVIRSPA
     QMRMKLIQKV VMGLFIGSLY WQQPLDPRGV RNTNSALYFL IAELTFSTMF GIMTFMEHEL
     PLIAREYHDG LFYVISYYIS RFLSYLPLFT IDGALMIVIS YWMIGLNSTW QQVAKSILIS
     VLVEQSATSC GLFLACLFET TSLAIAFAVP ASGLFALLSG LYGNTNNFPV YIRWMQWTSW
     CRYGFEGLVV NQWSQVDNPK WDPFYRELIL KQFSFNKDNY QLDVIGLCSI VIFFYLAGYI
     ALFIRIRLSR