WIF1_DANRE
ID WIF1_DANRE Reviewed; 378 AA.
AC Q9W6F9;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Wnt inhibitory factor 1;
DE Short=WIF-1;
DE Flags: Precursor;
GN Name=wif1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10201374; DOI=10.1038/18899;
RA Hsieh J.-C., Kodjabachian L., Rebbert M.L., Rattner A., Smallwood P.M.,
RA Samos C.H., Nusse R., Dawid I.B., Nathans J.;
RT "A new secreted protein that binds to Wnt proteins and inhibits their
RT activities.";
RL Nature 398:431-436(1999).
CC -!- FUNCTION: Binds to WNT proteins and inhibits their activities. May be
CC involved in mesoderm segmentation.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Highly expressed in unsegmented paraxial mesoderm.
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DR EMBL; AF122925; AAD25405.1; -; mRNA.
DR PIR; B59180; B59180.
DR RefSeq; NP_571304.1; NM_131229.1.
DR AlphaFoldDB; Q9W6F9; -.
DR SMR; Q9W6F9; -.
DR STRING; 7955.ENSDARP00000019818; -.
DR PaxDb; Q9W6F9; -.
DR GeneID; 30476; -.
DR KEGG; dre:30476; -.
DR CTD; 11197; -.
DR ZFIN; ZDB-GENE-990712-17; wif1.
DR eggNOG; KOG1225; Eukaryota.
DR InParanoid; Q9W6F9; -.
DR OrthoDB; 1016037at2759; -.
DR PhylomeDB; Q9W6F9; -.
DR PRO; PR:Q9W6F9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:ZFIN.
DR GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; IMP:ZFIN.
DR GO; GO:0048794; P:swim bladder development; IMP:ZFIN.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.2170; -; 1.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR003306; WIF.
DR InterPro; IPR038677; WIF_sf.
DR InterPro; IPR013309; Wnt-inh.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF02019; WIF; 1.
DR PRINTS; PR01901; WIFPROTEIN.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00469; WIF; 1.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS50814; WIF; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Disulfide bond; EGF-like domain; Glycoprotein;
KW Reference proteome; Repeat; Secreted; Signal; Wnt signaling pathway.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..378
FT /note="Wnt inhibitory factor 1"
FT /id="PRO_0000007779"
FT DOMAIN 36..175
FT /note="WIF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00222"
FT DOMAIN 176..205
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 208..240
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 243..272
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 272..304
FT /note="EGF-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 305..336
FT /note="EGF-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REGION 343..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 86
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 243
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 138..175
FT /evidence="ECO:0000250"
FT DISULFID 180..190
FT /evidence="ECO:0000250"
FT DISULFID 184..196
FT /evidence="ECO:0000250"
FT DISULFID 212..222
FT /evidence="ECO:0000250"
FT DISULFID 216..228
FT /evidence="ECO:0000250"
FT DISULFID 230..239
FT /evidence="ECO:0000250"
FT DISULFID 244..254
FT /evidence="ECO:0000250"
FT DISULFID 248..260
FT /evidence="ECO:0000250"
FT DISULFID 262..271
FT /evidence="ECO:0000250"
FT DISULFID 276..286
FT /evidence="ECO:0000250"
FT DISULFID 280..292
FT /evidence="ECO:0000250"
FT DISULFID 294..303
FT /evidence="ECO:0000250"
FT DISULFID 308..318
FT /evidence="ECO:0000250"
FT DISULFID 312..324
FT /evidence="ECO:0000250"
FT DISULFID 326..335
FT /evidence="ECO:0000250"
SQ SEQUENCE 378 AA; 41312 MW; 42FE9F70D948D1D8 CRC64;
MAFRTPAVQL HLKACVLLLL GGLLEAAYQE RGTMYMWIDA NQARILIGFE EDILIVSEGK
MAPFTHDFRK AQQRMPAIPV NIHHVNFTWQ ATDQAEYFYE FQTLRSLDKD IMDDPTVNVP
LLGSVPHKAS VVQVGFPCRG DQDGVAAFEV TILVMDAGGN IILRTPHNAI FFKTCQRAKC
PGGCRNGGYC NERQVCECQD GFYGVHCEKA LCSPRCLNGG LCMSPGVCIC PPGYFGSSCE
RANCSTTCLN GGTCFHPGKC ICAVSFEGVR CELSKCRQPC RNGGKCTGRN KCKCSKGYHG
DLCSKAVCEP SCGAHGTCVE PNRCQCREGW HGRHCNKRFR GGVSNSQRVS PSKHKSPSVA
AAKEAPETSQ PSETNYVV
