ID   WIPI2_CHICK             Reviewed;         436 AA.
AC   Q5ZHN3;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=WD repeat domain phosphoinositide-interacting protein 2;
DE            Short=WIPI-2;
GN   Name=WIPI2; ORFNames=RCJMB04_35d18;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of the autophagy machinery that controls the major
CC       intracellular degradation process by which cytoplasmic materials are
CC       packaged into autophagosomes and delivered to lysosomes for
CC       degradation. Involved in an early step of the formation of
CC       preautophagosomal structures. {ECO:0000250|UniProtKB:Q9Y4P8}.
CC   -!- SUBCELLULAR LOCATION: Preautophagosomal structure membrane
CC       {ECO:0000250|UniProtKB:Q9Y4P8}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q9Y4P8}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:Q9Y4P8}.
CC   -!- DOMAIN: The L/FRRG motif is required for recruitment to PtdIns3P.
CC       {ECO:0000250|UniProtKB:Q9Y4P8}.
CC   -!- SIMILARITY: Belongs to the WD repeat PROPPIN family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ721101; CAG32760.1; -; mRNA.
DR   RefSeq; NP_001006162.1; NM_001006162.1.
DR   AlphaFoldDB; Q5ZHN3; -.
DR   SMR; Q5ZHN3; -.
DR   STRING; 9031.ENSGALP00000007240; -.
DR   PaxDb; Q5ZHN3; -.
DR   Ensembl; ENSGALT00000007252; ENSGALP00000007240; ENSGALG00000004557.
DR   GeneID; 416481; -.
DR   KEGG; gga:416481; -.
DR   CTD; 26100; -.
DR   VEuPathDB; HostDB:geneid_416481; -.
DR   eggNOG; KOG2110; Eukaryota.
DR   GeneTree; ENSGT00940000155537; -.
DR   HOGENOM; CLU_025895_1_1_1; -.
DR   InParanoid; Q5ZHN3; -.
DR   OMA; PSRDFAW; -.
DR   OrthoDB; 1216824at2759; -.
DR   PhylomeDB; Q5ZHN3; -.
DR   TreeFam; TF314879; -.
DR   Reactome; R-GGA-1632852; Macroautophagy.
DR   PRO; PR:Q5ZHN3; -.
DR   Proteomes; UP000000539; Chromosome 14.
DR   Bgee; ENSGALG00000004557; Expressed in spermatid and 14 other tissues.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR   GO; GO:0034045; C:phagophore assembly site membrane; ISS:UniProtKB.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; ISS:UniProtKB.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB.
DR   GO; GO:0000045; P:autophagosome assembly; ISS:UniProtKB.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
DR   GO; GO:0044804; P:autophagy of nucleus; IBA:GO_Central.
DR   GO; GO:0009267; P:cellular response to starvation; ISS:UniProtKB.
DR   GO; GO:0006497; P:protein lipidation; IBA:GO_Central.
DR   GO; GO:0034497; P:protein localization to phagophore assembly site; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR032911; WIPI2.
DR   PANTHER; PTHR11227:SF27; PTHR11227:SF27; 1.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Lipid-binding; Membrane; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..436
FT                   /note="WD repeat domain phosphoinositide-interacting
FT                   protein 2"
FT                   /id="PRO_0000051443"
FT   REPEAT          182..222
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          228..267
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          311..349
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   MOTIF           223..226
FT                   /note="L/FRRG motif"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y4P8"
SQ   SEQUENCE   436 AA;  47775 MW;  8848FD63D5C49EE6 CRC64;
     MNLAGQSGDA GSGHLLFANF NQDNTSLAVG SKSGYKFFSL SSVDKLEQIY ECTDTEDVCI
     VERLFSSSLV AIVSLKAPRK LKVCHFKKGT EICNYSYSNT ILAVKLNRQR LIVCLEESLY
     IHNIRDMKVL HTIRETPPNP AGLCALSINN DNCYLAYPGS ATIGEVQVFD TINLRAANMI
     PAHDSPLAAL AFDASGTKLA TASEKGTVIR VFSIPEGQKL FEFRRGVKRC VSICSLAFSM
     DGMFLSASSN TETVHIFKLE TVKEKPQEEP TTWTGYFGKV LMASTSYLPS QVTEMFNQGR
     AFATVRLPFC GHKNICALAT IQKIPRLLVG AADGYLYMYN LDPQEGGECT LMKQHKLDGS
     MEPANEILES ASHDRPLVAQ TYSAAVTKGT YVPSSPTRHA YTEDLGAVGG ACLEDETNSL
     RLDEDSEHPP MILRTD