ID   WIPI3_PONAB             Reviewed;         344 AA.
AC   Q5R7W0;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=WD repeat domain phosphoinositide-interacting protein 3;
DE            Short=WIPI-3;
DE   AltName: Full=WD repeat-containing protein 45B;
GN   Name=WDR45B; Synonyms=WIPI3;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the autophagy machinery that controls the major
CC       intracellular degradation process by which cytoplasmic materials are
CC       packaged into autophagosomes and delivered to lysosomes for
CC       degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P), and
CC       other phosphoinositides including PtdIns(3,5)P2, forming on membranes
CC       of the endoplasmic reticulum upon activation of the upstream ULK1 and
CC       PI3 kinases and is recruited at phagophore assembly sites where it
CC       regulates the elongation of nascent phagophores downstream of WIPI2. In
CC       the cellular response to starvation, may also function together with
CC       the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1
CC       signaling pathway. {ECO:0000250|UniProtKB:Q5MNZ6}.
CC   -!- SUBUNIT: Interacts with the TSC1-TSC2 complex; stimulated upon
CC       starvation. Interacts with RB1CC1. {ECO:0000250|UniProtKB:Q5MNZ6}.
CC   -!- SUBCELLULAR LOCATION: Preautophagosomal structure
CC       {ECO:0000250|UniProtKB:Q5MNZ6}. Lysosome
CC       {ECO:0000250|UniProtKB:Q5MNZ6}.
CC   -!- DOMAIN: The L/FRRG motif is required for recruitment to PtdIns3P.
CC       {ECO:0000250|UniProtKB:Q9Y4P8}.
CC   -!- SIMILARITY: Belongs to the WD repeat PROPPIN family. {ECO:0000305}.
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DR   EMBL; CR859999; CAH92150.1; -; mRNA.
DR   RefSeq; NP_001127514.1; NM_001134042.1.
DR   AlphaFoldDB; Q5R7W0; -.
DR   SMR; Q5R7W0; -.
DR   STRING; 9601.ENSPPYP00000009860; -.
DR   GeneID; 100174590; -.
DR   KEGG; pon:100174590; -.
DR   CTD; 56270; -.
DR   eggNOG; KOG2111; Eukaryota.
DR   InParanoid; Q5R7W0; -.
DR   OrthoDB; 966922at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0000407; C:phagophore assembly site; ISS:UniProtKB.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; ISS:UniProtKB.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB.
DR   GO; GO:0000045; P:autophagosome assembly; ISS:UniProtKB.
DR   GO; GO:0009267; P:cellular response to starvation; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Lipid-binding; Lysosome; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..344
FT                   /note="WD repeat domain phosphoinositide-interacting
FT                   protein 3"
FT                   /id="PRO_0000051447"
FT   REPEAT          183..223
FT                   /note="WD 1"
FT   REPEAT          228..267
FT                   /note="WD 2"
FT   MOTIF           224..227
FT                   /note="L/FRRG motif"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y4P8"
SQ   SEQUENCE   344 AA;  38062 MW;  D6CAF24F1D28660C CRC64;
     MNLLPCNPHG NGLLYAGFNQ DHGCFACGME NGFRVYNTDP LKEKEKQEFL EGGVGHVEML
     FRCNYLALVG GGKKPKYPPN KVMIWDDLKK KTVIEIEFST EVKAVKLRRD RIVVVLDSMI
     KVFTFTHNPH QLHVFETCYN PKGLCVLCPN SNNSLLAFPG THTGHVQLVD LASTEKPPVD
     IPAHEGVLSC IALNLQGTRI ATASEKGTLI RIFDTSSGHL IQELRRGSQA ANIYCINSNQ
     DASLICVSSD HGTVHIFAAE DPKRNKQSSL ASASFLPKYF SSKWSFSKFQ VPSGSPCICA
     FGTEPNAVIA ICADGSYYKF LFNPKGECIR DVYAQFLEMT DDKL