ID   WIPI4_XENLA             Reviewed;         355 AA.
AC   Q6DCV0;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=WD repeat domain phosphoinositide-interacting protein 4;
DE            Short=WIPI-4;
DE   AltName: Full=WD repeat-containing protein 45;
GN   Name=wdr45; Synonyms=wipi4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the autophagy machinery that controls the major
CC       intracellular degradation process by which cytoplasmic materials are
CC       packaged into autophagosomes and delivered to lysosomes for degradation
CC       (By similarity). Binds phosphatidylinositol 3-phosphate (PtdIns3P) (By
CC       similarity). {ECO:0000250|UniProtKB:Q9Y484}.
CC   -!- SUBCELLULAR LOCATION: Preautophagosomal structure
CC       {ECO:0000250|UniProtKB:Q9Y484}.
CC   -!- DOMAIN: The L/FRRG motif is required for recruitment to PtdIns3P.
CC       {ECO:0000250|UniProtKB:Q9Y4P8}.
CC   -!- SIMILARITY: Belongs to the WD repeat PROPPIN family. {ECO:0000305}.
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DR   EMBL; BC077890; AAH77890.1; -; mRNA.
DR   RefSeq; NP_001087011.1; NM_001093542.1.
DR   AlphaFoldDB; Q6DCV0; -.
DR   SMR; Q6DCV0; -.
DR   PRIDE; Q6DCV0; -.
DR   DNASU; 446846; -.
DR   GeneID; 446846; -.
DR   KEGG; xla:446846; -.
DR   CTD; 446846; -.
DR   Xenbase; XB-GENE-972383; wdr45.S.
DR   OMA; FLCAVSD; -.
DR   OrthoDB; 966922at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 446846; Expressed in testis and 19 other tissues.
DR   GO; GO:0000407; C:phagophore assembly site; ISS:UniProtKB.
DR   GO; GO:1901981; F:phosphatidylinositol phosphate binding; ISS:UniProtKB.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB.
DR   GO; GO:0000045; P:autophagosome assembly; ISS:UniProtKB.
DR   GO; GO:0009267; P:cellular response to starvation; ISS:UniProtKB.
DR   GO; GO:2000786; P:positive regulation of autophagosome assembly; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR032910; WIPI4.
DR   PANTHER; PTHR11227:SF44; PTHR11227:SF44; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Lipid-binding; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..355
FT                   /note="WD repeat domain phosphoinositide-interacting
FT                   protein 4"
FT                   /id="PRO_0000051456"
FT   REPEAT          2..40
FT                   /note="WD 1"
FT   REPEAT          185..225
FT                   /note="WD 2"
FT   REPEAT          230..269
FT                   /note="WD 3"
FT   MOTIF           226..229
FT                   /note="L/FRRG motif"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y4P8"
SQ   SEQUENCE   355 AA;  39234 MW;  ECF24241AFC640EC CRC64;
     MSQQRGVNGL RFNQDQSCFC CAMETGVRIF NIEPLMEKGH LDQEQVGSVG QVEMLHRCNL
     LALVGGGSNP KFSDISVLIW DDSRDGKDKL VLEFTFTKPV LSVRLRSDKI VIALKNRIYV
     YSFPDNPTKL FEFDTRDNPK GLCDLCPSLE KQLLIFPGHK CGSLQLVDLC NAKPGSSSAP
     FTINAHQSEL GCLAINQQGT LVASASRKGT LIRLFDTQTR EQLVELRRGT DPATLYCINF
     SHDSSFLCSS SDKGTVHIFA LKDTKLNRRS ALARVGKVGP MIGQYVDSQW SLASFTVPAE
     SACICAFGKN TSKNVNSVIA VCVDGTFHKY VFTPEGNCNR EAFDVYLDIC DDDIF