WIT1_HUMAN
ID WIT1_HUMAN Reviewed; 92 AA.
AC Q06250; Q4KMY0; Q96A27;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 12-FEB-2003, sequence version 2.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=Putative Wilms tumor upstream neighbor 1 gene protein;
DE Short=WIT-1;
DE AltName: Full=Wilms tumor-associated antisense RNA;
GN Name=WT1-AS; Synonyms=WIT1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RX PubMed=2173145; DOI=10.1126/science.2173145;
RA Huang A., Campbell C.E., Bonetta L., McAndrews-Hill M.S.,
RA Chilton-Macneill S., Coppes M.J., Law D.J., Feinberg A.P., Yeger H.,
RA Williams B.R.;
RT "Tissue, developmental, and tumor-specific expression of divergent
RT transcripts in Wilms tumor.";
RL Science 250:991-994(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Placenta;
RX PubMed=8406502; DOI=10.1006/geno.1993.1355;
RA Gassler M., Bruns G.A.P.;
RT "Sequence of the WT1 upstream region including the Wit-1 gene.";
RL Genomics 17:499-501(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-66.
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q06250; Q6A162: KRT40; NbExp=3; IntAct=EBI-10223946, EBI-10171697;
CC Q06250; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-10223946, EBI-10172150;
CC Q06250; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10223946, EBI-10171774;
CC Q06250; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-10223946, EBI-10172052;
CC Q06250; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-10223946, EBI-741037;
CC Q06250; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-10223946, EBI-10172526;
CC Q06250; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10223946, EBI-945833;
CC Q06250; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-10223946, EBI-302345;
CC Q06250; P14373: TRIM27; NbExp=3; IntAct=EBI-10223946, EBI-719493;
CC Q06250; Q15654: TRIP6; NbExp=3; IntAct=EBI-10223946, EBI-742327;
CC -!- CAUTION: Product of a dubious CDS prediction. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA49572.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; M60614; AAA63269.1; -; mRNA.
DR EMBL; X69950; CAA49572.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AL049692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC002734; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC096708; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC098290; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC100673; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; A36233; A36233.
DR PIR; I39287; I39287.
DR AlphaFoldDB; Q06250; -.
DR IntAct; Q06250; 11.
DR iPTMnet; Q06250; -.
DR PhosphoSitePlus; Q06250; -.
DR BioMuta; HGNC:18135; -.
DR MassIVE; Q06250; -.
DR PRIDE; Q06250; -.
DR GeneCards; WT1-AS; -.
DR HGNC; HGNC:18135; WT1-AS.
DR MIM; 607899; gene.
DR neXtProt; NX_Q06250; -.
DR InParanoid; Q06250; -.
DR PathwayCommons; Q06250; -.
DR SignaLink; Q06250; -.
DR ChiTaRS; WT1-AS; human.
DR Pharos; Q06250; Tdark.
DR PRO; PR:Q06250; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q06250; protein.
PE 5: Uncertain;
KW Reference proteome.
FT CHAIN 1..92
FT /note="Putative Wilms tumor upstream neighbor 1 gene
FT protein"
FT /id="PRO_0000065977"
FT REGION 60..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 13
FT /note="A -> T (in dbSNP:rs6508)"
FT /id="VAR_014631"
FT VARIANT 66
FT /note="G -> A (in dbSNP:rs3087923)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_034563"
SQ SEQUENCE 92 AA; 10039 MW; 2FE20529E32FAC64 CRC64;
MQRRGQPLEN HVALIHWQSA GIPASKVHNY CNMKKSRLGR SRAVRISQPL LSPRRCPLHL
TERGAGLLQP QPQGPVRTPG PPSGSHPAAA DN
