WLSB_XENLA
ID WLSB_XENLA Reviewed; 541 AA.
AC Q5FWK6;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 52.
DE RecName: Full=Protein wntless homolog B;
DE Short=XWntless;
DE AltName: Full=Integral membrane protein GPR177-B;
GN Name=wls-b; Synonyms=gpr177-b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg, and Spleen;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=19223472; DOI=10.1128/mcb.01503-08;
RA Kim H., Cheong S.M., Ryu J., Jung H.J., Jho E.H., Han J.K.;
RT "Xenopus Wntless and the retromer complex cooperate to regulate XWnt4
RT secretion.";
RL Mol. Cell. Biol. 29:2118-2128(2009).
CC -!- FUNCTION: Required for a subset of Wnt-dependent developmental
CC processes, in particular, eye and pronephros development. Regulates the
CC secretion of wnt4, which is required for eye development.
CC {ECO:0000269|PubMed:19223472}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Enriched in the animal hemisphere of the early
CC cleavage embryo, where expression persists until the late gastrula
CC stage. At the neurula stage, strongly expressed at the border of the
CC neural plate and dorsal midline. After the neurula stage, expressed in
CC various organs, including the eye, liver, heart, pronephros, otic
CC vesicle, and dorsal neural tube. Expression in the developing eye is
CC dynamic; expressed in the eye field from stages 23 to 27, and from
CC stage 30 expression is confined to distinct regions including the
CC central part and border of the eye. {ECO:0000269|PubMed:19223472}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically, with
CC zygotic expression continuing to the tadpole stage (stage 42).
CC {ECO:0000269|PubMed:19223472}.
CC -!- SIMILARITY: Belongs to the wntless family. {ECO:0000305}.
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DR EMBL; BC089301; AAH89301.1; -; mRNA.
DR EMBL; BC110962; AAI10963.1; -; mRNA.
DR RefSeq; NP_001089953.1; NM_001096484.1.
DR AlphaFoldDB; Q5FWK6; -.
DR SMR; Q5FWK6; -.
DR BioGRID; 592804; 1.
DR DNASU; 735023; -.
DR GeneID; 735023; -.
DR KEGG; xla:735023; -.
DR CTD; 735023; -.
DR Xenbase; XB-GENE-956987; wls.L.
DR OrthoDB; 418201at2759; -.
DR Proteomes; UP000186698; Chromosome 4L.
DR Bgee; 735023; Expressed in internal ear and 19 other tissues.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0017147; F:Wnt-protein binding; IEA:InterPro.
DR GO; GO:0043010; P:camera-type eye development; IMP:UniProtKB.
DR GO; GO:0061357; P:positive regulation of Wnt protein secretion; IMP:UniProtKB.
DR GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IGI:UniProtKB.
DR GO; GO:0048793; P:pronephros development; IMP:UniProtKB.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR009551; Wntless.
DR PANTHER; PTHR13449; PTHR13449; 1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle; Developmental protein; Golgi apparatus; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix;
KW Wnt signaling pathway.
FT CHAIN 1..541
FT /note="Protein wntless homolog B"
FT /id="PRO_0000271783"
FT TOPO_DOM 1..15
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q5T9L3"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..232
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q5T9L3"
FT TRANSMEM 233..253
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q5T9L3"
FT TRANSMEM 269..289
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..303
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q5T9L3"
FT TRANSMEM 304..324
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q5T9L3"
FT TRANSMEM 332..352
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 353..379
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q5T9L3"
FT TRANSMEM 380..400
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 401..431
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q5T9L3"
FT TRANSMEM 432..452
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 453..471
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q5T9L3"
FT TRANSMEM 472..492
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 493..541
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q5T9L3"
SQ SEQUENCE 541 AA; 62001 MW; 60B14CF53B42E412 CRC64;
MAGAIIENMS TKKLCMVGVA LLLLQVLAFL VGGLIAPKPT TYVNPVAMKC IDVRKSHRSS
KWLMPWGTEP CKSIQSFDEA ANRLIEANDI VFAAHIPNSQ FEMSPWFQFM LVVLQLDIAF
KLNNYIEDHS MVTLDVAVAY RDDLKEEWKE LARSVEQRKL NCILPVDKTV ANEGRHYDCD
VIPLMELGSV SHKYYLFNIR LPVNERQKMN IGIGEIRDMH VVSIFQNGGF TMVWFAMKTF
LTPCIIIIMI WYWRRITMMT RSPVLLEKVI FALGISMTFI NIPVEWFSIG YDWTWMLLFG
DIRQGIFYAM LLSFWIIFCG EHMMDQAERN RISIYWKQVG PIAFGSCCLF IFDMCERGVQ
LKNPFYSIWT TDVGAEIAMA FIIVAGICAC LYFLFLCFMV YQVFRNISGK RSNLPAMSKA
RRLHYEGLIF RFKFLMIITL ACAALTVVFF ITTQITEGNW KLGDLSIELN SAFFTGIYGM
WNLYVFALMF LYAPSHKHYG DGQSNDGAGM SSGEELQLTT TITHIDGPTE LYRLAGKEAQ
E
