ID   WLS_CHICK               Reviewed;         541 AA.
AC   Q5ZLR1;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Protein wntless homolog;
DE   AltName: Full=Integral membrane protein GPR177;
DE   Flags: Precursor;
GN   Name=WLS; Synonyms=GPR177; ORFNames=RCJMB04_5c7;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: May play an essential role in Wnt signaling pathway. May be
CC       required for Wnt-dependent patterning processes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the wntless family. {ECO:0000305}.
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DR   EMBL; AJ719673; CAG31332.1; -; mRNA.
DR   RefSeq; NP_001026465.1; NM_001031294.1.
DR   AlphaFoldDB; Q5ZLR1; -.
DR   SMR; Q5ZLR1; -.
DR   STRING; 9031.ENSGALP00000018306; -.
DR   PaxDb; Q5ZLR1; -.
DR   GeneID; 424707; -.
DR   KEGG; gga:424707; -.
DR   CTD; 79971; -.
DR   VEuPathDB; HostDB:geneid_424707; -.
DR   eggNOG; ENOG502QSE2; Eukaryota.
DR   InParanoid; Q5ZLR1; -.
DR   OrthoDB; 418201at2759; -.
DR   PhylomeDB; Q5ZLR1; -.
DR   PRO; PR:Q5ZLR1; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031301; C:integral component of organelle membrane; IBA:GO_Central.
DR   GO; GO:0017147; F:Wnt-protein binding; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0061357; P:positive regulation of Wnt protein secretion; ISS:ParkinsonsUK-UCL.
DR   GO; GO:0030177; P:positive regulation of Wnt signaling pathway; ISS:ParkinsonsUK-UCL.
DR   GO; GO:0061355; P:Wnt protein secretion; IBA:GO_Central.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR009551; Wntless.
DR   PANTHER; PTHR13449; PTHR13449; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Developmental protein; Golgi apparatus; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix;
KW   Wnt signaling pathway.
FT   SIGNAL          1..42
FT                   /evidence="ECO:0000255"
FT   CHAIN           43..541
FT                   /note="Protein wntless homolog"
FT                   /id="PRO_0000271781"
FT   TOPO_DOM        43..232
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        254..268
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        290..303
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        304..324
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        325..331
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        332..352
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        353..380
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        402..431
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        432..452
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        453..471
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        472..492
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        493..541
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   541 AA;  62137 MW;  B3C06FA2A21E016C CRC64;
     MAGAIIENMS TRKLCIVGGI LLVFQVIAFL VGGLIAPSPT TAVPYMSVKC IDVRKNHHKT
     KWLMPWGPNH CEKLKDFDEA VSRQIEANDI VFAVHIPLPS KEMSPWFQFM LFIMQLDIAF
     KMDNDLKENA EITLDVSLAY RDDMFNDWEE IAHAIEIRKL KCTFGSPKTL ESEGRHYDCD
     FLPFMEIGSV AHKYYLINIR LPVNERKGIN VGIGEVKDIR LVGIHQNGGF TKVWFAMKTF
     LTPSILIIMV WYWRRITLMT RAPVLLEKVI FALGISMTFI NIPVEWFSIG FDWTWMLLFG
     DIRQGIFYAM LLSFWIIFCG EHMMDQNERN RLSGYWKQVG PIAVGSFCLF IFDMCERGVQ
     LKNPFYSIWT TEVGTELAMA FIIVAGICLC LYFLFLCFMV FQVFRNISGK QSSLPAMSKA
     RRLHYEGLIF RFKFLMLITL ACAAMTVIFF IVSQVTEGHW KWGDITIQVN SAFFTGIYGM
     WNLYVFALMF LYAPSHKNYG EDQSNGDLGV SSGEELQLTT TITHVDGPTE VYKLARKEAQ
     E