WLS_PONAB
ID WLS_PONAB Reviewed; 541 AA.
AC Q5R9R3; Q5R8N2; Q5R9G6;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 53.
DE RecName: Full=Protein wntless homolog;
DE AltName: Full=Integral membrane protein GPR177;
DE AltName: Full=Protein evenness interrupted homolog;
DE Short=EVI;
GN Name=WLS; Synonyms=GPR177;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates Wnt proteins sorting and secretion in a feedback
CC regulatory mechanism. This reciprocal interaction plays a key role in
CC the regulation of expression, subcellular location, binding and
CC organelle-specific association of Wnt proteins. Also plays an important
CC role in establishment of the anterior-posterior body axis formation
CC during development (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with WNT3A. Interacts with WNT1, WNT3 and WNT5A.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q5T9L3}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q5T9L3}. Cytoplasmic vesicle membrane
CC {ECO:0000250|UniProtKB:Q5T9L3}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q5T9L3}. Cell membrane
CC {ECO:0000250|UniProtKB:Q5T9L3}; Multi-pass membrane protein
CC {ECO:0000255}. Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q5T9L3}; Multi-pass membrane protein
CC {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q5T9L3};
CC Multi-pass membrane protein {ECO:0000255}. Early endosome membrane
CC {ECO:0000250|UniProtKB:Q5T9L3}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the wntless family. {ECO:0000305}.
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DR EMBL; CR859319; CAH91497.1; -; mRNA.
DR EMBL; CR859422; CAH91594.1; -; mRNA.
DR EMBL; CR859719; CAH91878.1; -; mRNA.
DR RefSeq; NP_001125940.1; NM_001132468.1.
DR AlphaFoldDB; Q5R9R3; -.
DR SMR; Q5R9R3; -.
DR STRING; 9601.ENSPPYP00000001456; -.
DR GeneID; 100172874; -.
DR KEGG; pon:100172874; -.
DR CTD; 79971; -.
DR eggNOG; ENOG502QSE2; Eukaryota.
DR InParanoid; Q5R9R3; -.
DR OrthoDB; 418201at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017147; F:Wnt-protein binding; IEA:InterPro.
DR GO; GO:0009948; P:anterior/posterior axis specification; ISS:UniProtKB.
DR GO; GO:0016055; P:Wnt signaling pathway; ISS:UniProtKB.
DR InterPro; IPR009551; Wntless.
DR PANTHER; PTHR13449; PTHR13449; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytoplasmic vesicle; Developmental protein;
KW Endoplasmic reticulum; Endosome; Golgi apparatus; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix;
KW Wnt signaling pathway.
FT CHAIN 1..541
FT /note="Protein wntless homolog"
FT /id="PRO_0000271778"
FT TOPO_DOM 1..15
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q5T9L3"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..232
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q5T9L3"
FT TRANSMEM 233..253
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q5T9L3"
FT TRANSMEM 269..289
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..303
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q5T9L3"
FT TRANSMEM 304..324
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q5T9L3"
FT TRANSMEM 332..352
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 353..380
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q5T9L3"
FT TRANSMEM 381..401
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 402..431
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q5T9L3"
FT TRANSMEM 432..452
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 453..471
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q5T9L3"
FT TRANSMEM 472..492
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 493..541
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q5T9L3"
FT REGION 101..232
FT /note="Interaction with Wnt proteins"
FT /evidence="ECO:0000250"
FT CONFLICT 10
FT /note="G -> S (in Ref. 1; CAH91878/CAH91594)"
FT /evidence="ECO:0000305"
FT CONFLICT 196
FT /note="L -> P (in Ref. 1; CAH91594)"
FT /evidence="ECO:0000305"
FT CONFLICT 301
FT /note="D -> Y (in Ref. 1; CAH91878)"
FT /evidence="ECO:0000305"
FT CONFLICT 448
FT /note="I -> T (in Ref. 1; CAH91878)"
FT /evidence="ECO:0000305"
FT CONFLICT 507
FT /note="D -> N (in Ref. 1; CAH91594)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 541 AA; 62223 MW; 0DAFDF5507AAB048 CRC64;
MAGAIIENMG TKKLCIVGGI LLVFQIIAFL VGGLIAPGPT TAVSYMSVKC VDARKNHHKT
KWFVPWGPNH CDKIRDIEEA IPREIEANDI VFSVHIPLPH MEMSPWFQFM LFILQLDIAF
KLNNQIRENA EVSMDVSLAY RDDAFAEWTE MAHERVPRKL KCTFTSPKTP EHEGRYYECD
VLPFMEIGSV AHKFYLLNIR LPVNEKKKIN VGIGEIKDIR LVGIHQNGGF TKVWFAMKTF
LTPSIFIIMV WYWRRITMMS RPPVLLEKVI FALGISMTFI NIPVEWFSIG FDWTWMLLFG
DIRQGIFYAM LLSFWIIFCG EHMMDQHERN HIAGYWKQVG PIAVGSFCLF IFDMCERGVQ
LTNPFYSIWT TDIGTELAMA FIIVAGICLC LYFLFLCFMV FQVFRNISGK QSSLPAMSKV
RRLHYEGLIF RFKFLMLITL ACAAMTVIFF IVSQVTEGHW KWGGVTVQVN SAFFTGIYGM
WNLYVFALMF LYAPSHKNYG EDQSNGDLGV HSGEELQLTT TITHVDGPTE IYKLTRKEAQ
E
