ID   WN10B_PLEJO             Reviewed;         117 AA.
AC   P28132;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Protein Wnt-10b;
DE   Flags: Fragment;
GN   Name=WNT-10B;
OS   Plethodon jordani (Red-cheeked salamander).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Plethodontidae; Plethodontinae;
OC   Plethodon.
OX   NCBI_TaxID=8336;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1534411; DOI=10.1073/pnas.89.11.5098;
RA   Sidow A.;
RT   "Diversification of the Wnt gene family on the ancestral lineage of
RT   vertebrates.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:5098-5102(1992).
CC   -!- FUNCTION: Member of the Wnt ligand gene family that encodes for
CC       secreted proteins, which activate the Wnt signaling cascade. Involved
CC       in neurogenesis. Performs a partially redundant function with wnt1 in
CC       the formation of the midbrain-hindbrain boundary (MHB) organizer.
CC       {ECO:0000250|UniProtKB:Q801F7}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250|UniProtKB:O00744}. Secreted
CC       {ECO:0000250|UniProtKB:O00744}.
CC   -!- PTM: Palmitoleoylation is required for efficient binding to frizzled
CC       receptors. Depalmitoleoylation leads to Wnt signaling pathway
CC       inhibition. {ECO:0000250|UniProtKB:P27467,
CC       ECO:0000250|UniProtKB:P56704}.
CC   -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
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DR   EMBL; M91289; AAA49457.1; -; Genomic_DNA.
DR   AlphaFoldDB; P28132; -.
DR   SMR; P28132; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2460.20; -; 1.
DR   InterPro; IPR005817; Wnt.
DR   InterPro; IPR043158; Wnt_C.
DR   PANTHER; PTHR12027; PTHR12027; 1.
DR   Pfam; PF00110; wnt; 1.
DR   SMART; SM00097; WNT1; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Disulfide bond; Extracellular matrix; Glycoprotein;
KW   Lipoprotein; Secreted; Wnt signaling pathway.
FT   CHAIN           <1..>117
FT                   /note="Protein Wnt-10b"
FT                   /id="PRO_0000200666"
FT   LIPID           1
FT                   /note="O-palmitoleoyl serine; by PORCN"
FT                   /evidence="ECO:0000250|UniProtKB:P56704"
FT   CARBOHYD        84
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        83..98
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   NON_TER         1
FT   NON_TER         117
SQ   SEQUENCE   117 AA;  13486 MW;  0314FA6F60182D41 CRC64;
     SGSCQFKTCW HVTPEFRLVS SVLKEKFQRA TFINSHNKNT GVFHPRRLKK KRLAKELVYF
     EKSPDFCERD TKVDSPGTQG RVCNKTSHQM DSCGNLCCGR GHNILMQTPS ERCNCRF