WNK11_ARATH
ID WNK11_ARATH Reviewed; 314 AA.
AC Q6ICW6; Q9FGV9;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Probable serine/threonine-protein kinase WNK11;
DE Short=AtWNK11;
DE EC=2.7.11.1;
DE AltName: Full=Protein kinase with no lysine 11;
GN Name=WNK11; OrderedLocusNames=At5g55560; ORFNames=MWC10.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May regulate flowering time by modulating the photoperiod
CC pathway. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. WNK subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC -!- CAUTION: Was named WNK/'with no lysine(K)' because key residues for
CC catalysis, including the lysine involved in ATP binding, are either not
CC conserved or differ compared to the residues described in other kinase
CC family proteins. {ECO:0000250|UniProtKB:Q9H4A3}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB08753.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB023043; BAB08753.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED96649.1; -; Genomic_DNA.
DR EMBL; BT014907; AAT46036.1; -; mRNA.
DR EMBL; BT015030; AAT70481.1; -; mRNA.
DR RefSeq; NP_200367.2; NM_124938.5.
DR AlphaFoldDB; Q6ICW6; -.
DR SMR; Q6ICW6; -.
DR BioGRID; 20894; 3.
DR STRING; 3702.AT5G55560.1; -.
DR iPTMnet; Q6ICW6; -.
DR PaxDb; Q6ICW6; -.
DR PRIDE; Q6ICW6; -.
DR ProteomicsDB; 242722; -.
DR EnsemblPlants; AT5G55560.1; AT5G55560.1; AT5G55560.
DR GeneID; 835650; -.
DR Gramene; AT5G55560.1; AT5G55560.1; AT5G55560.
DR KEGG; ath:AT5G55560; -.
DR Araport; AT5G55560; -.
DR TAIR; locus:2176135; AT5G55560.
DR eggNOG; KOG0584; Eukaryota.
DR HOGENOM; CLU_000288_63_23_1; -.
DR InParanoid; Q6ICW6; -.
DR OMA; YRKVTNV; -.
DR OrthoDB; 695382at2759; -.
DR PhylomeDB; Q6ICW6; -.
DR PRO; PR:Q6ICW6; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q6ICW6; baseline and differential.
DR Genevisible; Q6ICW6; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR Pfam; PF00069; Pkinase; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome;
KW Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..314
FT /note="Probable serine/threonine-protein kinase WNK11"
FT /id="PRO_0000351669"
FT DOMAIN 31..289
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 178
FT /note="Proton acceptor"
FT /evidence="ECO:0000250|UniProtKB:Q9JIH7"
FT BINDING 111..114
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250|UniProtKB:Q9H4A3"
SQ SEQUENCE 314 AA; 35531 MW; D47C38C9D5D39445 CRC64;
MMTCASSDDN ESEKDKDSES FVEVDPTGRY GRYGELLGSG AVKKVYRAFD QEEGIEVAWN
QVKLRCFSDD PAMTERLYSE VRLLKNLKNS NIITLYKVWR DERNNTLNFI TEICTSGNLR
EYRKKHRHVS MRALKKWSKQ ILKGLDYLHT HDPCIIHRDL NCSNIFVNGN IGQVKIGDLG
LAAIVGKNHL AHSILGTPEF MAPELYEENY TEMVDIYSYG MCVLELVSLE IPYSECDSVA
KIYKRVSKGL KPEALNKVND PEAKAFIEKC IAQPRARPSA AELLCDPFFD GILDDDDEDG
ENNDNNGAGR IVVS
