WNT11_CHICK
ID WNT11_CHICK Reviewed; 354 AA.
AC P49339;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Protein Wnt-11;
DE Flags: Precursor;
GN Name=WNT11; Synonyms=WNT-11;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7779076; DOI=10.1006/bbrc.1995.1786;
RA Tanda N., Ohuchi H., Yoshioka H., Noji S., Nohno T.;
RT "A chicken Wnt gene, Wnt-11, is involved in dermal development.";
RL Biochem. Biophys. Res. Commun. 211:123-129(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7579581; DOI=10.3109/10425179509030981;
RA Tanda N., Kawakami Y., Saito T., Noji S., Nohno T.;
RT "Cloning and characterization of Wnt-4 and Wnt-11 cDNAs from chick
RT embryo.";
RL DNA Seq. 5:277-281(1995).
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. May play a role in the formation of dermal
CC structure, both limb and feather buds. Is likely to signal over only
CC few cell diameters.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix.
CC -!- TISSUE SPECIFICITY: Expressed in the dermatome. The expression domain
CC is mutually exclusive to the other Wnt genes.
CC -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis.
CC -!- PTM: Palmitoleoylation is required for efficient binding to frizzled
CC receptors. Depalmitoleoylation leads to Wnt signaling pathway
CC inhibition. {ECO:0000250|UniProtKB:P27467,
CC ECO:0000250|UniProtKB:P56704}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D31901; BAA06699.1; -; mRNA.
DR PIR; JC4152; JC4152.
DR RefSeq; NP_990115.1; NM_204784.1.
DR RefSeq; XP_015136337.1; XM_015280851.1.
DR AlphaFoldDB; P49339; -.
DR SMR; P49339; -.
DR STRING; 9031.ENSGALP00000042987; -.
DR PaxDb; P49339; -.
DR Ensembl; ENSGALT00000001231; ENSGALP00000001229; ENSGALG00000000839.
DR GeneID; 395562; -.
DR KEGG; gga:395562; -.
DR CTD; 7481; -.
DR VEuPathDB; HostDB:geneid_395562; -.
DR eggNOG; KOG3913; Eukaryota.
DR GeneTree; ENSGT00940000158413; -.
DR InParanoid; P49339; -.
DR OMA; CKLLPGM; -.
DR OrthoDB; 797177at2759; -.
DR PhylomeDB; P49339; -.
DR TreeFam; TF105310; -.
DR Reactome; R-GGA-3238698; WNT ligand biogenesis and trafficking.
DR Reactome; R-GGA-4086398; Ca2+ pathway.
DR PRO; PR:P49339; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000000839; Expressed in lung and 3 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IMP:AgBase.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005109; F:frizzled binding; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; ISS:UniProtKB.
DR GO; GO:0030295; F:protein kinase activator activity; ISS:UniProtKB.
DR GO; GO:0030325; P:adrenal gland development; IEA:Ensembl.
DR GO; GO:0048844; P:artery morphogenesis; IEA:Ensembl.
DR GO; GO:0003283; P:atrial septum development; IEA:Ensembl.
DR GO; GO:0070830; P:bicellular tight junction assembly; IEA:Ensembl.
DR GO; GO:0030282; P:bone mineralization; IEA:Ensembl.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0045165; P:cell fate commitment; IMP:AgBase.
DR GO; GO:0016477; P:cell migration; IMP:AgBase.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0060197; P:cloacal septation; IEA:Ensembl.
DR GO; GO:0060028; P:convergent extension involved in axis elongation; IEA:Ensembl.
DR GO; GO:0035113; P:embryonic appendage morphogenesis; IMP:AgBase.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IMP:AgBase.
DR GO; GO:1904019; P:epithelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0001837; P:epithelial to mesenchymal transition; IMP:AgBase.
DR GO; GO:0060325; P:face morphogenesis; IMP:AgBase.
DR GO; GO:0060484; P:lung-associated mesenchyme development; IEA:Ensembl.
DR GO; GO:0045199; P:maintenance of epithelial cell apical/basal polarity; IEA:Ensembl.
DR GO; GO:0010463; P:mesenchymal cell proliferation; IEA:Ensembl.
DR GO; GO:0072177; P:mesonephric duct development; IEA:Ensembl.
DR GO; GO:0045445; P:myoblast differentiation; IDA:AgBase.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IMP:AgBase.
DR GO; GO:0060548; P:negative regulation of cell death; ISS:UniProtKB.
DR GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
DR GO; GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:AgBase.
DR GO; GO:0090272; P:negative regulation of fibroblast growth factor production; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:AgBase.
DR GO; GO:0072201; P:negative regulation of mesenchymal cell proliferation; IEA:Ensembl.
DR GO; GO:2000647; P:negative regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0061101; P:neuroendocrine cell differentiation; ISS:UniProtKB.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0048570; P:notochord morphogenesis; IEA:Ensembl.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR GO; GO:0048341; P:paraxial mesoderm formation; IEA:Ensembl.
DR GO; GO:0003402; P:planar cell polarity pathway involved in axis elongation; IEA:Ensembl.
DR GO; GO:0060775; P:planar cell polarity pathway involved in gastrula mediolateral intercalation; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR GO; GO:1904037; P:positive regulation of epithelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:AgBase.
DR GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.
DR GO; GO:0090082; P:positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0090037; P:positive regulation of protein kinase C signaling; ISS:UniProtKB.
DR GO; GO:0051496; P:positive regulation of stress fiber assembly; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0032915; P:positive regulation of transforming growth factor beta2 production; IEA:Ensembl.
DR GO; GO:0003138; P:primary heart field specification; IEA:Ensembl.
DR GO; GO:1903929; P:primary palate development; IMP:AgBase.
DR GO; GO:0034394; P:protein localization to cell surface; ISS:UniProtKB.
DR GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
DR GO; GO:0003139; P:secondary heart field specification; IEA:Ensembl.
DR GO; GO:0062009; P:secondary palate development; ISS:UniProtKB.
DR GO; GO:0043589; P:skin morphogenesis; IMP:AgBase.
DR GO; GO:0061053; P:somite development; IEA:Ensembl.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR GO; GO:0060675; P:ureteric bud morphogenesis; IEA:Ensembl.
DR GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
DR GO; GO:0060071; P:Wnt signaling pathway, planar cell polarity pathway; IMP:AgBase.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR026536; Wnt-11.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027; PTHR12027; 1.
DR PANTHER; PTHR12027:SF7; PTHR12027:SF7; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Disulfide bond; Extracellular matrix; Glycoprotein;
KW Lipoprotein; Reference proteome; Secreted; Signal; Wnt signaling pathway.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..354
FT /note="Protein Wnt-11"
FT /id="PRO_0000041467"
FT LIPID 215
FT /note="O-palmitoleoyl serine; by PORCN"
FT /evidence="ECO:0000250|UniProtKB:P56704"
FT CARBOHYD 40
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 90
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 300
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 304
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 80..91
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 130..138
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 140..157
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 209..223
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 211..218
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 283..314
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 299..309
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 313..353
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 329..344
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 331..341
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 336..337
FT /evidence="ECO:0000250|UniProtKB:P28026"
SQ SEQUENCE 354 AA; 39507 MW; 2D3A69F06DA385F8 CRC64;
MKPSPQFFLA AFLSLILQTG ICYGIKWIAL SKTPSSLALN QTQHCKQLEG LVVSQVQLCR
SNLELMQTII QAAREVIKTC RKTFSDMRWN CSSIELAPNY LLDLERGTRE SAFVYALSAA
AISHTIARAC TTGDLPGCSC GPIPGETPGP GYRWGGCADN LNYGLIMGSK FSDAPMKMKK
SGSQANKLMH LHNSEVGRQV LKASLEMKCK CHGVSGSCSI KTCWKGLQEL RDIALDLKNK
YLSATKVVHR PMGTRKYLVP KDIDIRPVKE TELIYLQSSP DFCMKNEKVG SHGTQDRQCN
KTSNGSDSCD LMCCGRGYNP YMDKVVERCH CKYHWCCYVT CKKCERTVER YVCK
