WNT11_MOUSE
ID WNT11_MOUSE Reviewed; 354 AA.
AC P48615;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Protein Wnt-11;
DE Flags: Precursor;
GN Name=Wnt11; Synonyms=Wnt-11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=SWR/J;
RX PubMed=7547479; DOI=10.1016/0925-4773(95)00383-5;
RA Christiansen J.H., Dennis C.L., Wicking C.A., Monkley S.J., Wilkinson D.G.,
RA Wainwright B.J.;
RT "Murine Wnt-11 and Wnt-12 have temporally and spatially restricted
RT expression patterns during embryonic development.";
RL Mech. Dev. 51:341-350(1995).
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. Probable developmental protein. May be a
CC signaling molecule which affects the development of discrete regions of
CC tissues. Is likely to signal over only few cell diameters.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix.
CC -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis.
CC -!- PTM: Palmitoleoylation is required for efficient binding to frizzled
CC receptors. Depalmitoleoylation leads to Wnt signaling pathway
CC inhibition. {ECO:0000250|UniProtKB:P27467,
CC ECO:0000250|UniProtKB:P56704}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
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DR EMBL; X70800; CAA50070.1; -; mRNA.
DR CCDS; CCDS21475.1; -.
DR PIR; S34378; S34378.
DR RefSeq; NP_001272721.1; NM_001285792.1.
DR RefSeq; NP_033545.1; NM_009519.2.
DR RefSeq; XP_006507649.1; XM_006507586.3.
DR AlphaFoldDB; P48615; -.
DR SMR; P48615; -.
DR BioGRID; 204570; 3.
DR STRING; 10090.ENSMUSP00000132166; -.
DR GlyGen; P48615; 5 sites.
DR PhosphoSitePlus; P48615; -.
DR PaxDb; P48615; -.
DR PRIDE; P48615; -.
DR ProteomicsDB; 297852; -.
DR Antibodypedia; 31189; 143 antibodies from 31 providers.
DR DNASU; 22411; -.
DR Ensembl; ENSMUST00000067495; ENSMUSP00000064333; ENSMUSG00000015957.
DR Ensembl; ENSMUST00000167303; ENSMUSP00000132166; ENSMUSG00000015957.
DR GeneID; 22411; -.
DR KEGG; mmu:22411; -.
DR UCSC; uc009ikv.3; mouse.
DR CTD; 7481; -.
DR MGI; MGI:101948; Wnt11.
DR VEuPathDB; HostDB:ENSMUSG00000015957; -.
DR eggNOG; KOG3913; Eukaryota.
DR GeneTree; ENSGT00940000158413; -.
DR HOGENOM; CLU_033039_1_0_1; -.
DR InParanoid; P48615; -.
DR OMA; CKLLPGM; -.
DR OrthoDB; 797177at2759; -.
DR PhylomeDB; P48615; -.
DR TreeFam; TF105310; -.
DR Reactome; R-MMU-3238698; WNT ligand biogenesis and trafficking.
DR Reactome; R-MMU-4086398; Ca2+ pathway.
DR Reactome; R-MMU-4086400; PCP/CE pathway.
DR BioGRID-ORCS; 22411; 0 hits in 74 CRISPR screens.
DR PRO; PR:P48615; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P48615; protein.
DR Bgee; ENSMUSG00000015957; Expressed in mesenchyme from somatopleure and 221 other tissues.
DR ExpressionAtlas; P48615; baseline and differential.
DR Genevisible; P48615; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0031012; C:extracellular matrix; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005109; F:frizzled binding; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; ISS:UniProtKB.
DR GO; GO:0030295; F:protein kinase activator activity; ISS:UniProtKB.
DR GO; GO:0005102; F:signaling receptor binding; TAS:MGI.
DR GO; GO:0030325; P:adrenal gland development; IEA:Ensembl.
DR GO; GO:0009887; P:animal organ morphogenesis; TAS:MGI.
DR GO; GO:0006915; P:apoptotic process; IMP:MGI.
DR GO; GO:0048844; P:artery morphogenesis; IMP:MGI.
DR GO; GO:0003283; P:atrial septum development; IGI:CACAO.
DR GO; GO:0070830; P:bicellular tight junction assembly; IMP:MGI.
DR GO; GO:0030282; P:bone mineralization; IGI:MGI.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IDA:MGI.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0007267; P:cell-cell signaling; TAS:MGI.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IDA:MGI.
DR GO; GO:0060197; P:cloacal septation; IEA:Ensembl.
DR GO; GO:0060028; P:convergent extension involved in axis elongation; IGI:MGI.
DR GO; GO:0048706; P:embryonic skeletal system development; IEA:Ensembl.
DR GO; GO:1904019; P:epithelial cell apoptotic process; IMP:MGI.
DR GO; GO:0001837; P:epithelial to mesenchymal transition; IGI:MGI.
DR GO; GO:0001822; P:kidney development; IDA:MGI.
DR GO; GO:0060484; P:lung-associated mesenchyme development; IEA:Ensembl.
DR GO; GO:0045199; P:maintenance of epithelial cell apical/basal polarity; IGI:MGI.
DR GO; GO:0010463; P:mesenchymal cell proliferation; IMP:MGI.
DR GO; GO:0072177; P:mesonephric duct development; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:MGI.
DR GO; GO:0060548; P:negative regulation of cell death; ISS:UniProtKB.
DR GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
DR GO; GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.
DR GO; GO:0090272; P:negative regulation of fibroblast growth factor production; IMP:MGI.
DR GO; GO:0072201; P:negative regulation of mesenchymal cell proliferation; IMP:MGI.
DR GO; GO:2000647; P:negative regulation of stem cell proliferation; IMP:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0061101; P:neuroendocrine cell differentiation; ISS:UniProtKB.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0035567; P:non-canonical Wnt signaling pathway; IMP:MGI.
DR GO; GO:0048570; P:notochord morphogenesis; IGI:MGI.
DR GO; GO:0001649; P:osteoblast differentiation; IGI:MGI.
DR GO; GO:0003151; P:outflow tract morphogenesis; IMP:MGI.
DR GO; GO:0048341; P:paraxial mesoderm formation; IGI:MGI.
DR GO; GO:0003402; P:planar cell polarity pathway involved in axis elongation; IGI:MGI.
DR GO; GO:0060775; P:planar cell polarity pathway involved in gastrula mediolateral intercalation; IGI:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IMP:MGI.
DR GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR GO; GO:1904037; P:positive regulation of epithelial cell apoptotic process; IMP:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.
DR GO; GO:0090082; P:positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway; IGI:CACAO.
DR GO; GO:0090037; P:positive regulation of protein kinase C signaling; ISS:UniProtKB.
DR GO; GO:0051496; P:positive regulation of stress fiber assembly; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0032915; P:positive regulation of transforming growth factor beta2 production; IMP:MGI.
DR GO; GO:0003138; P:primary heart field specification; IGI:CACAO.
DR GO; GO:0034394; P:protein localization to cell surface; ISS:UniProtKB.
DR GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
DR GO; GO:0031667; P:response to nutrient levels; IEA:Ensembl.
DR GO; GO:0060021; P:roof of mouth development; IMP:MGI.
DR GO; GO:0003139; P:secondary heart field specification; IGI:CACAO.
DR GO; GO:0062009; P:secondary palate development; ISS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; TAS:MGI.
DR GO; GO:0061053; P:somite development; IGI:MGI.
DR GO; GO:0072089; P:stem cell proliferation; IMP:MGI.
DR GO; GO:0060675; P:ureteric bud morphogenesis; IEA:Ensembl.
DR GO; GO:0003281; P:ventricular septum development; IGI:CACAO.
DR GO; GO:0060412; P:ventricular septum morphogenesis; IMP:MGI.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR026536; Wnt-11.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027; PTHR12027; 1.
DR PANTHER; PTHR12027:SF7; PTHR12027:SF7; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Disulfide bond; Extracellular matrix; Glycoprotein;
KW Lipoprotein; Reference proteome; Secreted; Signal; Wnt signaling pathway.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..354
FT /note="Protein Wnt-11"
FT /id="PRO_0000041466"
FT LIPID 215
FT /note="O-palmitoleoyl serine; by PORCN"
FT /evidence="ECO:0000250|UniProtKB:P56704"
FT CARBOHYD 40
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 90
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 160
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 300
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 304
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 80..91
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 130..138
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 140..157
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 209..223
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 211..218
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 283..314
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 299..309
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 313..353
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 329..344
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 331..341
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 336..337
FT /evidence="ECO:0000250|UniProtKB:P28026"
SQ SEQUENCE 354 AA; 39135 MW; ED582FDD8427D37E CRC64;
MRARPQVCEA LLFALALHTG VCYGIKWLAL SKTPAALALN QTQHCKQLEG LVSAQVQLCR
SNLELMRTIV HAARGAMKAC RRAFADMRWN CSSIELAPNY LLDLERGTRE SAFVYALSAA
TISHTIARAC TSGDLPGCSC GPVPGEPPGP GNRWGGCADN LSYGLLMGAK FSDAPMKVKK
TGSQANKLMR LHNSEVGRQA LRASLETKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR
YLSATKVVHR PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN
KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER YVCK
