WNT16_MOUSE
ID WNT16_MOUSE Reviewed; 364 AA.
AC Q9QYS1; Q14BF7;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Protein Wnt-16;
DE Flags: Precursor;
GN Name=Wnt16;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=10500199; DOI=10.1073/pnas.96.20.11464;
RA McWhirter J.R., Neuteboom S.T., Wancewicz E.V., Monia B.P., Downing J.R.,
RA Murre C.;
RT "Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT
RT gene in pre-B acute lymphoblastoid leukemia.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:11464-11469(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. Probable developmental protein. May be a
CC signaling molecule which affects the development of discrete regions of
CC tissues. Is likely to signal over only few cell diameters (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix.
CC -!- PTM: Palmitoleoylation is required for efficient binding to frizzled
CC receptors. Depalmitoleoylation leads to Wnt signaling pathway
CC inhibition. {ECO:0000250|UniProtKB:P27467,
CC ECO:0000250|UniProtKB:P56704}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
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DR EMBL; AF172064; AAD49352.2; -; Genomic_DNA.
DR EMBL; AF169964; AAD49352.2; JOINED; Genomic_DNA.
DR EMBL; CH466533; EDL13846.1; -; Genomic_DNA.
DR EMBL; BC115811; AAI15812.1; -; mRNA.
DR EMBL; BC115925; AAI15926.1; -; mRNA.
DR CCDS; CCDS19936.1; -.
DR RefSeq; NP_444346.3; NM_053116.4.
DR AlphaFoldDB; Q9QYS1; -.
DR SMR; Q9QYS1; -.
DR STRING; 10090.ENSMUSP00000031681; -.
DR GlyGen; Q9QYS1; 3 sites.
DR PhosphoSitePlus; Q9QYS1; -.
DR PaxDb; Q9QYS1; -.
DR PRIDE; Q9QYS1; -.
DR ProteomicsDB; 297853; -.
DR Antibodypedia; 17566; 216 antibodies from 31 providers.
DR DNASU; 93735; -.
DR Ensembl; ENSMUST00000031681; ENSMUSP00000031681; ENSMUSG00000029671.
DR GeneID; 93735; -.
DR KEGG; mmu:93735; -.
DR UCSC; uc009bax.2; mouse.
DR CTD; 51384; -.
DR MGI; MGI:2136018; Wnt16.
DR VEuPathDB; HostDB:ENSMUSG00000029671; -.
DR eggNOG; KOG3913; Eukaryota.
DR GeneTree; ENSGT00940000157480; -.
DR HOGENOM; CLU_033039_1_0_1; -.
DR InParanoid; Q9QYS1; -.
DR OMA; RGRECNR; -.
DR OrthoDB; 745245at2759; -.
DR PhylomeDB; Q9QYS1; -.
DR TreeFam; TF105310; -.
DR Reactome; R-MMU-3238698; WNT ligand biogenesis and trafficking.
DR BioGRID-ORCS; 93735; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q9QYS1; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9QYS1; protein.
DR Bgee; ENSMUSG00000029671; Expressed in secondary palatal shelf mesenchyme and 93 other tissues.
DR ExpressionAtlas; Q9QYS1; baseline and differential.
DR Genevisible; Q9QYS1; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005109; F:frizzled binding; IBA:GO_Central.
DR GO; GO:0046849; P:bone remodeling; IMP:MGI.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0060317; P:cardiac epithelial to mesenchymal transition; IMP:MGI.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0030216; P:keratinocyte differentiation; ISO:MGI.
DR GO; GO:0043616; P:keratinocyte proliferation; ISO:MGI.
DR GO; GO:0060548; P:negative regulation of cell death; ISO:MGI.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0090403; P:oxidative stress-induced premature senescence; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR GO; GO:0046330; P:positive regulation of JNK cascade; ISO:MGI.
DR GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISO:MGI.
DR GO; GO:0090399; P:replicative senescence; ISO:MGI.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR013304; Wnt16.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027; PTHR12027; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01895; WNT16PROTEIN.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Disulfide bond; Extracellular matrix; Glycoprotein;
KW Lipoprotein; Reference proteome; Secreted; Signal; Wnt signaling pathway.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..364
FT /note="Protein Wnt-16"
FT /id="PRO_0000041472"
FT LIPID 226
FT /note="O-palmitoleoyl serine; by PORCN"
FT /evidence="ECO:0000250|UniProtKB:P56704"
FT CARBOHYD 142
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 310
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 81..92
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 138..146
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 148..167
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 220..234
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 222..229
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 293..324
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 309..319
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 323..363
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 339..354
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 341..351
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 346..347
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT CONFLICT 265
FT /note="K -> N (in Ref. 1; AAD49352)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 364 AA; 40727 MW; 68A71C82DDE2D3A2 CRC64;
MDRAALLALP SLCALWAAVL SLLPCGTQGN WMWLGIASFG VPEKLGCADL PLNSRQKELC
KRKPYLLPSI REGARLGIQE CRSQFRHERW NCMVATTTST QLATAPLFGY ELSSGTKETA
FIYAIMAAGL VHSVTRSCSA GNMTECSCDT TLQNGGSPSE GWHWGGCSDD VQYGMWFSRK
FLDLPIRNTT GKESRVLLAM NLHNNEAGRQ AVAKLMSVDC RCHGVSGSCA VKTCWKTMSS
FEKIGHFLKD KYENSIQISD KTKRKMRRRE KDQRQTPILK DDLLYVHKSP NYCVENKKLG
IPGTQGRECN RTSGGADGCN LLCCGRGYNT HVVRHVERCE CKFIWCCYVR CRRCESMTDV
HTCK
