ID   WNT1_BOMMO              Reviewed;         392 AA.
AC   P49340;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Protein Wnt-1;
DE   Flags: Precursor;
GN   Name=WNT-1;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Amanai K., Hui C., Kokubo H., Ueno K., Suzuki Y.;
RL   Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ligand for members of the frizzled family of seven
CC       transmembrane receptors. Probable developmental protein.
CC       {ECO:0000250|UniProtKB:Q91029}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250|UniProtKB:P04628}. Secreted
CC       {ECO:0000250|UniProtKB:P04628}.
CC   -!- PTM: Palmitoleoylated by porcupine. The lipid group functions as a
CC       sorting signal, targeting the ligand to polarized vesicles that
CC       transport WNT-1 to unique sites at the cell surface. Depalmitoleoylated
CC       by notum, leading to inhibit Wnt signaling pathway.
CC       {ECO:0000250|UniProtKB:P09615}.
CC   -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
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DR   EMBL; D14169; BAA03211.1; -; mRNA.
DR   RefSeq; NP_001037315.1; NM_001043850.1.
DR   AlphaFoldDB; P49340; -.
DR   SMR; P49340; -.
DR   PRIDE; P49340; -.
DR   GeneID; 692745; -.
DR   KEGG; bmor:692745; -.
DR   CTD; 692745; -.
DR   InParanoid; P49340; -.
DR   OrthoDB; 624528at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0048699; P:generation of neurons; IEA:UniProt.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2460.20; -; 1.
DR   InterPro; IPR005817; Wnt.
DR   InterPro; IPR043158; Wnt_C.
DR   InterPro; IPR018161; Wnt_CS.
DR   PANTHER; PTHR12027; PTHR12027; 1.
DR   Pfam; PF00110; wnt; 1.
DR   PRINTS; PR01349; WNTPROTEIN.
DR   SMART; SM00097; WNT1; 1.
DR   PROSITE; PS00246; WNT1; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Disulfide bond; Extracellular matrix; Glycoprotein;
KW   Lipoprotein; Reference proteome; Secreted; Signal; Wnt signaling pathway.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..392
FT                   /note="Protein Wnt-1"
FT                   /id="PRO_0000041481"
FT   LIPID           233
FT                   /note="O-palmitoleoyl serine; by PORCN"
FT                   /evidence="ECO:0000250|UniProtKB:P56704"
FT   CARBOHYD        99
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        338
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        368
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        89..100
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        142..150
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        152..179
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        227..241
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        229..236
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        321..352
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        337..347
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        351..391
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        367..382
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        369..379
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        374..375
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
SQ   SEQUENCE   392 AA;  44204 MW;  EE25BFE2810F44D6 CRC64;
     MKCLWLLVIT VLCLRCDTAG TKPRRGRGSM WWGIAKAGEP NNLSPVSPGV LFMDPAVHAT
     LRRKQRRLAR ENPGVLAAVA KAQYAFAECQ HQFKYRRWNC STRNFLRGKN LFGKIVDRGC
     RETAFIYAIT SAGVTHSLAR ACREASIESC TCDYSHRPRA AQNPVGGRAN VRVWKWGGCS
     DNIGFGFRFS REFVDTGERG KTLREKMNLH NNEAGRRHVQ TEMKQECKCH GMSGSCTVKT
     CWMRLPSFRS VGDSLKDRFD GASRVMLSKA DVETPAQRNE AAPHRVPRKD RYRFQLRPHN
     PDHKSPGVKD LVYLESSPGF CEKNPRLGIP GTHGRACNDT SIGVDGCDLM CCGRGYKTNT
     MFVVERCNCT FHWCCEVKCK LCRTEKVVHT CL