ID   WNT1_STRPU              Reviewed;         223 AA.
AC   P28094;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Protein Wnt-1;
DE   Flags: Fragment;
GN   Name=WNT-1;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Ferkowicz M.J., Stander M.C., Raff R.A.;
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 78-202.
RX   PubMed=1534411; DOI=10.1073/pnas.89.11.5098;
RA   Sidow A.;
RT   "Diversification of the Wnt gene family on the ancestral lineage of
RT   vertebrates.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:5098-5102(1992).
CC   -!- FUNCTION: Ligand for members of the frizzled family of seven
CC       transmembrane receptors. Probable developmental protein.
CC       {ECO:0000250|UniProtKB:Q91029}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250|UniProtKB:P04628}. Secreted
CC       {ECO:0000250|UniProtKB:P04628}.
CC   -!- PTM: Palmitoleoylation is required for efficient binding to frizzled
CC       receptors. Palmitoleoylation is necessary for proper trafficking to
CC       cell surface (By similarity). Depalmitoleoylated by NOTUM, leading to
CC       inhibit Wnt signaling pathway (By similarity).
CC       {ECO:0000250|UniProtKB:P56704, ECO:0000250|UniProtKB:Q91029}.
CC   -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
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DR   EMBL; U88625; AAC69241.1; -; mRNA.
DR   EMBL; M91302; AAA30083.1; -; Genomic_DNA.
DR   AlphaFoldDB; P28094; -.
DR   SMR; P28094; -.
DR   STRING; 7668.SPU_011756-tr; -.
DR   PRIDE; P28094; -.
DR   eggNOG; KOG3913; Eukaryota.
DR   HOGENOM; CLU_033039_1_1_1; -.
DR   InParanoid; P28094; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005109; F:frizzled binding; IBA:GO_Central.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   Gene3D; 3.30.2460.20; -; 1.
DR   InterPro; IPR005817; Wnt.
DR   InterPro; IPR043158; Wnt_C.
DR   InterPro; IPR018161; Wnt_CS.
DR   PANTHER; PTHR12027; PTHR12027; 1.
DR   Pfam; PF00110; wnt; 1.
DR   PRINTS; PR01349; WNTPROTEIN.
DR   SMART; SM00097; WNT1; 1.
DR   PROSITE; PS00246; WNT1; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Disulfide bond; Extracellular matrix; Glycoprotein;
KW   Lipoprotein; Reference proteome; Secreted; Wnt signaling pathway.
FT   CHAIN           <1..223
FT                   /note="Protein Wnt-1"
FT                   /id="PRO_0000200607"
FT   REGION          110..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           78
FT                   /note="O-palmitoleoyl serine; by PORCN"
FT                   /evidence="ECO:0000250|UniProtKB:Q91029"
FT   CARBOHYD        169
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        7..24
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        72..86
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        74..81
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        152..183
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        168..178
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        182..222
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        198..213
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        200..210
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        205..206
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   NON_TER         1
SQ   SEQUENCE   223 AA;  25236 MW;  50D839A3B10A8D62 CRC64;
     TIESCTCDYK FRGDSGNDWE WGGCSDNADF GHRFGKKFVD SGEKGRDLRH AMNLHNNEAG
     RKTVSSEMRR ECKCHGMSGS CTIETCWMRL PTFRTVGELI KERFDGASRV TMRNDGSPSD
     RETESSFVPY NPSHKQPASR DLVYFENSPD FCERNDKFGT PGTRGRECNA TSLGVDGCDL
     MCCSRGSTTT EIKVKERCSC TFHWCCKVKC EECTSFRTVH RCL