WNT2_DANRE
ID WNT2_DANRE Reviewed; 350 AA.
AC Q92048;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Protein Wnt-2;
DE Flags: Precursor;
GN Name=wnt2; Synonyms=wnt-2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RA Blader P., Straehle U., Ingham P.W.;
RT "Three Wnt genes expressed in a wide variety of tissues during development
RT of the zebrafish, Danio rerio: developmental and evolutionary
RT perspectives.";
RL Dev. Genes Evol. 206:3-13(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. Functions in the canonical Wnt signaling
CC pathway that results in activation of transcription factors of the
CC TCF/LEF family (By similarity). {ECO:0000250|UniProtKB:P09544,
CC ECO:0000250|UniProtKB:P21552}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250|UniProtKB:P09544}. Secreted
CC {ECO:0000250|UniProtKB:P09544}.
CC -!- DEVELOPMENTAL STAGE: First detected in the developing viscera at 30
CC hours. Expression is gone by 5 days. {ECO:0000269|Ref.1}.
CC -!- PTM: Palmitoleoylation is required for efficient binding to frizzled
CC receptors. Depalmitoleoylation leads to Wnt signaling pathway
CC inhibition. {ECO:0000250|UniProtKB:P09544}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
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DR EMBL; U51266; AAA96517.1; -; mRNA.
DR EMBL; BC056277; AAH56277.1; -; mRNA.
DR RefSeq; NP_571025.1; NM_130950.1.
DR AlphaFoldDB; Q92048; -.
DR SMR; Q92048; -.
DR STRING; 7955.ENSDARP00000060258; -.
DR PaxDb; Q92048; -.
DR PRIDE; Q92048; -.
DR Ensembl; ENSDART00000060259; ENSDARP00000060258; ENSDARG00000041117.
DR Ensembl; ENSDART00000187460; ENSDARP00000154555; ENSDARG00000115436.
DR GeneID; 30127; -.
DR KEGG; dre:30127; -.
DR CTD; 7472; -.
DR ZFIN; ZDB-GENE-980526-416; wnt2.
DR eggNOG; KOG3913; Eukaryota.
DR GeneTree; ENSGT00940000159231; -.
DR HOGENOM; CLU_033039_1_4_1; -.
DR InParanoid; Q92048; -.
DR OMA; HVDHAIK; -.
DR OrthoDB; 745245at2759; -.
DR PhylomeDB; Q92048; -.
DR TreeFam; TF105310; -.
DR Reactome; R-DRE-3238698; WNT ligand biogenesis and trafficking.
DR PRO; PR:Q92048; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 18.
DR Bgee; ENSDARG00000041117; Expressed in pharyngeal gill and 6 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005109; F:frizzled binding; IBA:GO_Central.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0042074; P:cell migration involved in gastrulation; ISS:UniProtKB.
DR GO; GO:0072574; P:hepatocyte proliferation; IMP:ZFIN.
DR GO; GO:0001889; P:liver development; IMP:ZFIN.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0048794; P:swim bladder development; IMP:ZFIN.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR009140; Wnt2.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027; PTHR12027; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01842; WNT2PROTEIN.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Disulfide bond; Extracellular matrix; Glycoprotein;
KW Lipoprotein; Reference proteome; Secreted; Signal; Wnt signaling pathway.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..350
FT /note="Protein Wnt-2"
FT /id="PRO_0000041412"
FT LIPID 210
FT /note="O-palmitoleoyl serine; by PORCN"
FT /evidence="ECO:0000250|UniProtKB:P56704"
FT CARBOHYD 132
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 293
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 74..85
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 125..133
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 135..155
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 204..218
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 206..213
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 276..307
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 292..302
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 306..346
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 322..337
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 324..334
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 329..330
FT /evidence="ECO:0000250|UniProtKB:P28026"
SQ SEQUENCE 350 AA; 39789 MW; F6268DADE9361C6C CRC64;
MNFLPNGICF YLSVAICWFS SRVDASWWYM GTLGSQVMCD NIPGLINKQR QLCRQHPKVM
QAIGAGIKNW IGECQHQFRT HRWNCNTMAR EHNLFGRLLH RSSREAAFVY AISSAGMVYT
LTRACSQGEL ENCSCDPGKK GSSRDAKGAF DWGGCSDHVD HAIKFTQVFI DAKERKERDA
RALMNLHNNR AGRKAVKRFM NLECKCHGVS GSCNVRTCWL AMADFRQTGD YLRKKYNNAI
QVVMNQYGTG FTSAYRMLKR PNKNDLVYFE DSPDYCIWDH ESGSVGTGGR VCNRTSRGTD
SCEVMCCGRG YDTSRVSRTT KCECKFQWCC AVHCRDCQEE VDVHTCKTQS
