ID   WNT3_EPTST              Reviewed;         123 AA.
AC   P28114;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Protein Wnt-3;
DE   Flags: Fragment;
GN   Name=WNT-3;
OS   Eptatretus stoutii (Pacific hagfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata; Myxini;
OC   Myxiniformes; Myxinidae; Eptatretinae; Eptatretus.
OX   NCBI_TaxID=7765;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1534411; DOI=10.1073/pnas.89.11.5098;
RA   Sidow A.;
RT   "Diversification of the Wnt gene family on the ancestral lineage of
RT   vertebrates.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:5098-5102(1992).
CC   -!- FUNCTION: Ligand for members of the frizzled family of seven
CC       transmembrane receptors (By similarity). Functions in the canonical Wnt
CC       signaling pathway that results in activation of transcription factors
CC       of the TCF/LEF family (By similarity). Required for normal embryonic
CC       development (By similarity). {ECO:0000250|UniProtKB:P17553,
CC       ECO:0000250|UniProtKB:P56703}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250|UniProtKB:P56703}. Secreted
CC       {ECO:0000250|UniProtKB:P56703}.
CC   -!- PTM: Palmitoleoylation is required for efficient binding to frizzled
CC       receptors. Depalmitoleoylation leads to Wnt signaling pathway
CC       inhibition. {ECO:0000250|UniProtKB:P27467,
CC       ECO:0000250|UniProtKB:P56704}.
CC   -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
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DR   EMBL; M91264; AAA49246.1; -; Genomic_DNA.
DR   AlphaFoldDB; P28114; -.
DR   SMR; P28114; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2460.20; -; 1.
DR   InterPro; IPR005817; Wnt.
DR   InterPro; IPR043158; Wnt_C.
DR   PANTHER; PTHR12027; PTHR12027; 1.
DR   Pfam; PF00110; wnt; 1.
DR   SMART; SM00097; WNT1; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Disulfide bond; Extracellular matrix; Glycoprotein;
KW   Lipoprotein; Secreted; Wnt signaling pathway.
FT   CHAIN           <1..>123
FT                   /note="Protein Wnt-3"
FT                   /id="PRO_0000200611"
FT   LIPID           1
FT                   /note="O-palmitoleoyl serine; by PORCN"
FT                   /evidence="ECO:0000250|UniProtKB:P56704"
FT   CARBOHYD        90
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        89..104
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   NON_TER         1
FT   NON_TER         123
SQ   SEQUENCE   123 AA;  14048 MW;  7CC8F5A4B7872455 CRC64;
     SGSCEVKTCW VAQPDFRSIG DHLKDKYDSA SEMVVEKHKE ARGWVETLRP KYPLFKPPTD
     RDLIYYERSP NFCDPNSETG SFGTKDRVCN LTSHGIDGCD LLCCGRGHNT RTEKRKDKCH
     CVF