ID   WNT3_EVATR              Reviewed;         124 AA.
AC   P28090;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Protein Wnt-3;
DE   Flags: Fragment;
GN   Name=WNT-3;
OS   Evasterias troschelii (Mottled sea star) (Asterias troschelii).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Asterozoa; Asteroidea;
OC   Forcipulatacea; Forcipulatida; Asteriidae; Evasterias.
OX   NCBI_TaxID=7616;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1534411; DOI=10.1073/pnas.89.11.5098;
RA   Sidow A.;
RT   "Diversification of the Wnt gene family on the ancestral lineage of
RT   vertebrates.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:5098-5102(1992).
CC   -!- FUNCTION: Ligand for members of the frizzled family of seven
CC       transmembrane receptors (By similarity). Functions in the canonical Wnt
CC       signaling pathway that results in activation of transcription factors
CC       of the TCF/LEF family (By similarity). Required for normal embryonic
CC       development (By similarity). {ECO:0000250|UniProtKB:P17553,
CC       ECO:0000250|UniProtKB:P56703}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250|UniProtKB:P56703}. Secreted
CC       {ECO:0000250|UniProtKB:P56703}.
CC   -!- PTM: Palmitoleoylation is required for efficient binding to frizzled
CC       receptors. Depalmitoleoylation leads to Wnt signaling pathway
CC       inhibition. {ECO:0000250|UniProtKB:P27467,
CC       ECO:0000250|UniProtKB:P56704}.
CC   -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
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DR   EMBL; M91273; AAA29131.1; -; Genomic_DNA.
DR   AlphaFoldDB; P28090; -.
DR   SMR; P28090; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2460.20; -; 1.
DR   InterPro; IPR005817; Wnt.
DR   InterPro; IPR043158; Wnt_C.
DR   PANTHER; PTHR12027; PTHR12027; 1.
DR   Pfam; PF00110; wnt; 1.
DR   SMART; SM00097; WNT1; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Disulfide bond; Extracellular matrix; Glycoprotein;
KW   Lipoprotein; Secreted; Wnt signaling pathway.
FT   CHAIN           <1..>124
FT                   /note="Protein Wnt-3"
FT                   /id="PRO_0000200610"
FT   REGION          40..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           1
FT                   /note="O-palmitoleoyl serine; by PORCN"
FT                   /evidence="ECO:0000250|UniProtKB:P56704"
FT   CARBOHYD        91
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        90..105
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   NON_TER         1
FT   NON_TER         124
SQ   SEQUENCE   124 AA;  14040 MW;  9C2A6756BC431C1A CRC64;
     SGSCEVKTCW MQTPHFKEVG DRLLVKYQNA KRVVARNSIG GGLGLANVPK KKRKRAPPPP
     EDQLVFLEDS PNFCNPDGEI GIFGTKDRYC NRTSDGADRC DTMCCGRGYN IKLERRTEWC
     YCQF