WNT4_STRPU
ID WNT4_STRPU Reviewed; 133 AA.
AC P28096;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 2.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Protein Wnt-4;
DE Flags: Fragment;
GN Name=WNT-4;
OS Strongylocentrotus purpuratus (Purple sea urchin).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC Strongylocentrotus.
OX NCBI_TaxID=7668;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1534411; DOI=10.1073/pnas.89.11.5098;
RA Sidow A.;
RT "Diversification of the Wnt gene family on the ancestral lineage of
RT vertebrates.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:5098-5102(1992).
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors (Probable). Plays an important role in
CC embryonic development (By similarity). {ECO:0000250|UniProtKB:P22724,
CC ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix.
CC -!- PTM: Palmitoleoylation is required for efficient binding to frizzled
CC receptors. Depalmitoleoylation leads to Wnt signaling pathway
CC inhibition. {ECO:0000250|UniProtKB:P27467,
CC ECO:0000250|UniProtKB:P56704}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
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DR EMBL; M95841; AAA30085.1; -; Genomic_DNA.
DR EMBL; M95840; AAA30085.1; JOINED; Genomic_DNA.
DR AlphaFoldDB; P28096; -.
DR SMR; P28096; -.
DR InParanoid; P28096; -.
DR Proteomes; UP000007110; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005109; F:frizzled binding; IBA:GO_Central.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR043158; Wnt_C.
DR PANTHER; PTHR12027; PTHR12027; 1.
DR Pfam; PF00110; wnt; 1.
DR SMART; SM00097; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein; Disulfide bond; Extracellular matrix; Glycoprotein;
KW Lipoprotein; Reference proteome; Secreted; Wnt signaling pathway.
FT CHAIN <1..>133
FT /note="Protein Wnt-4"
FT /id="PRO_0000200627"
FT LIPID 1
FT /note="O-palmitoleoyl serine; by PORCN"
FT /evidence="ECO:0000250|UniProtKB:P56704"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 69..114
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 99..109
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT NON_TER 1
FT NON_TER 133
SQ SEQUENCE 133 AA; 14702 MW; 64A8F384EE3C128D CRC64;
SGSCEMKTCW KSMPTFGDIG QVLKEKFDGA TEVQSLKIGS RQQLVPTQRD FKPHTSSDLV
YLVPSPDFCE EDLKVSIPVG LTFSHPPNQG SLGTHGRRCN KTSKAIDGCE LMCCGRGFNT
HIEEVIERCS CKF