WNT5A_MELGA
ID WNT5A_MELGA Reviewed; 116 AA.
AC P28128;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Protein Wnt-5a;
DE Flags: Fragment;
GN Name=WNT5A;
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1534411; DOI=10.1073/pnas.89.11.5098;
RA Sidow A.;
RT "Diversification of the Wnt gene family on the ancestral lineage of
RT vertebrates.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:5098-5102(1992).
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. Can activate or inhibit canonical Wnt
CC signaling, depending on receptor context. Required during embryogenesis
CC for extension of the primary anterior-posterior axis.
CC {ECO:0000250|UniProtKB:P22725}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250|UniProtKB:P41221}. Secreted
CC {ECO:0000250|UniProtKB:P41221}.
CC -!- PTM: Palmitoleoylation is required for efficient binding to frizzled
CC receptors. Depalmitoleoylation leads to Wnt signaling pathway
CC inhibition. {ECO:0000250|UniProtKB:P27467,
CC ECO:0000250|UniProtKB:P56704}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
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DR EMBL; M91284; AAA49633.1; -; Genomic_DNA.
DR AlphaFoldDB; P28128; -.
DR SMR; P28128; -.
DR InParanoid; P28128; -.
DR Proteomes; UP000001645; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR026538; Wnt5a.
DR InterPro; IPR043158; Wnt_C.
DR PANTHER; PTHR12027; PTHR12027; 1.
DR PANTHER; PTHR12027:SF33; PTHR12027:SF33; 1.
DR Pfam; PF00110; wnt; 1.
DR SMART; SM00097; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein; Disulfide bond; Extracellular matrix; Glycoprotein;
KW Lipoprotein; Reference proteome; Secreted; Wnt signaling pathway.
FT CHAIN <1..>116
FT /note="Protein Wnt-5a"
FT /id="PRO_0000200631"
FT LIPID 1
FT /note="O-palmitoleoyl serine; by PORCN"
FT /evidence="ECO:0000250|UniProtKB:P56704"
FT CARBOHYD 69
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 83
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 82..97
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT NON_TER 1
FT NON_TER 116
SQ SEQUENCE 116 AA; 12997 MW; AB14BB7673662BCF CRC64;
SGSCSLKTCW LQLADFRKVG DALKEKYDSA AAMKLNSRGK LVQMNSRFNA PTIHDLIYID
PSPDYCMRNE STGSLGTQGR LCNKTSEGMD GCELMCCGRG YDQFKTVERE RCNCKF