ID   WNT5A_PLEWA             Reviewed;         359 AA.
AC   O13267;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Protein Wnt-5a;
DE            Short=PWnt-5a;
DE   Flags: Precursor;
GN   Name=WNT5A;
OS   Pleurodeles waltl (Iberian ribbed newt).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Salamandridae; Pleurodelinae;
OC   Pleurodeles.
OX   NCBI_TaxID=8319;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9286590;
RX   DOI=10.1002/(sici)1097-0177(199709)210:1<1::aid-aja1>3.0.co;2-l;
RA   Caubit X., Nicolas S., Le Parco Y.;
RT   "Possible roles for Wnt genes in growth and axial patterning during
RT   regeneration of the tail in urodele amphibians.";
RL   Dev. Dyn. 210:1-10(1997).
CC   -!- FUNCTION: Ligand for members of the frizzled family of seven
CC       transmembrane receptors. Can activate or inhibit canonical Wnt
CC       signaling, depending on receptor context. Required during embryogenesis
CC       for extension of the primary anterior-posterior axis.
CC       {ECO:0000250|UniProtKB:P22725}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250|UniProtKB:P41221}. Secreted
CC       {ECO:0000250|UniProtKB:P41221}.
CC   -!- PTM: Palmitoleoylation is required for efficient binding to frizzled
CC       receptors. Depalmitoleoylation leads to Wnt signaling pathway
CC       inhibition. {ECO:0000250|UniProtKB:P27467,
CC       ECO:0000250|UniProtKB:P56704}.
CC   -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
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DR   EMBL; U80582; AAB58495.1; -; Genomic_DNA.
DR   AlphaFoldDB; O13267; -.
DR   SMR; O13267; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2460.20; -; 1.
DR   InterPro; IPR005817; Wnt.
DR   InterPro; IPR026538; Wnt5a.
DR   InterPro; IPR043158; Wnt_C.
DR   InterPro; IPR018161; Wnt_CS.
DR   PANTHER; PTHR12027; PTHR12027; 1.
DR   PANTHER; PTHR12027:SF33; PTHR12027:SF33; 1.
DR   Pfam; PF00110; wnt; 1.
DR   PRINTS; PR01349; WNTPROTEIN.
DR   SMART; SM00097; WNT1; 1.
DR   PROSITE; PS00246; WNT1; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Disulfide bond; Extracellular matrix; Glycoprotein;
KW   Lipoprotein; Secreted; Signal; Wnt signaling pathway.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..359
FT                   /note="Protein Wnt-5a"
FT                   /id="PRO_0000041430"
FT   LIPID           223
FT                   /note="O-palmitoleoyl serine; by PORCN"
FT                   /evidence="ECO:0000250|UniProtKB:P56704"
FT   CARBOHYD        93
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        99
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        291
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        305
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        83..94
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        133..141
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        143..161
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        217..231
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        219..226
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        288..319
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        304..314
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        318..358
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        334..349
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        336..346
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        341..342
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
SQ   SEQUENCE   359 AA;  40346 MW;  425CF9C6614137FB CRC64;
     MASRYLTLAA ALLASFLQVD IEANSWWSLA MNPVQIPEAY IVGAQPLCSQ LAGLSPGQKK
     LCQLYQDHMQ YIGEGAKTGI KECQYQFRHR RWNCSTVDNI SVFGRVMQIG SRETAFTYSI
     SAAGVVNAVS RACRAGELST CGCSRARRPK DLQRDWLWGG CGDNLDYGYR FAKEFVDARE
     REKIHQKGSY ESSRTLMNLH NNEAGRRTVY NLADVACKCH GVSGSCSLKT CWLQLADFRK
     VGDFLKEKYD SAASMKLNSR GKLVQVNSRF NPPTTNDLVY VDPSPDYCVR NESTGSMGTQ
     GRLCNKTSEG MDGCELMCCG RGYDQFKTVQ TERCHCKFHW CCYVKCKKCT EIVDQFVCK