WNT5A_RAT
ID WNT5A_RAT Reviewed; 380 AA.
AC Q9QXQ7; Q5PY99;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Protein Wnt-5a;
DE Flags: Precursor;
GN Name=Wnt5a; Synonyms=Wnt-5a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=15309358; DOI=10.1007/s00221-004-1887-0;
RA Peters S., Mix E., Bauer P., Weinelt S., Schubert B., Knoblich R.,
RA Boettcher T., Strauss U., Pahnke J., Cattaneo E., Wree A., Rolfs A.;
RT "Wnt-5a expression in the rat neuronal progenitor cell line ST14A.";
RL Exp. Brain Res. 158:189-195(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Corpus luteum;
RA Lacher M.D., Walther P.R., Lareu R.R., Dharmarajan A.M., Friis R.R.;
RT "Coexpression of Wnt-5a, Wnt-4, frizzled-4, and DDC4 (frpAP, a secreted
RT Frizzled, AF012891) in the pregnant ovary.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. Can activate or inhibit canonical Wnt
CC signaling, depending on receptor context. In the presence of FZD4,
CC activates beta-catenin signaling. In the presence of ROR2, inhibits the
CC canonical Wnt pathway by promoting beta-catenin degradation through a
CC GSK3-independent pathway which involves down-regulation of beta-
CC catenin-induced reporter gene expression (By similarity). Suppression
CC of the canonical pathway allows chondrogenesis to occur and inhibits
CC tumor formation. Stimulates cell migration. Decreases proliferation,
CC migration, invasiveness and clonogenicity of carcinoma cells and may
CC act as a tumor suppressor. Mediates motility of melanoma cells (By
CC similarity). Required during embryogenesis for extension of the primary
CC anterior-posterior axis and for outgrowth of limbs and the genital
CC tubercle. Inhibits type II collagen expression in chondrocytes (By
CC similarity). {ECO:0000250|UniProtKB:P22725,
CC ECO:0000250|UniProtKB:P41221, ECO:0000250|UniProtKB:Q27Q52}.
CC -!- SUBUNIT: Forms a soluble 1:1 complex with AFM; this prevents
CC oligomerization and is required for prolonged biological activity. The
CC complex with AFM may represent the physiological form in body fluids
CC (By similarity). Homooligomer; disulfide-linked, leading to
CC inactivation (in vitro). Interacts with PORCN. Interacts with WLS (By
CC similarity). Interacts with glypican GCP3 (By similarity). Interacts
CC with PKD1 (via extracellular domain) (By similarity).
CC {ECO:0000250|UniProtKB:P22725, ECO:0000250|UniProtKB:P41221}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250|UniProtKB:P41221}. Secreted
CC {ECO:0000250|UniProtKB:P41221}.
CC -!- PTM: Glycosylation is necessary for secretion but not for activity.
CC {ECO:0000250|UniProtKB:P22725}.
CC -!- PTM: Palmitoleoylation is required for efficient binding to frizzled
CC receptors. Depalmitoleoylation leads to Wnt signaling pathway
CC inhibition. {ECO:0000250|UniProtKB:P27467,
CC ECO:0000250|UniProtKB:P56704}.
CC -!- PTM: Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and
CC formation of large disulfide-bond oligomers, leading to inactivation of
CC WNT5A. {ECO:0000250|UniProtKB:P22725}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
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DR EMBL; AY819646; AAV69750.1; -; mRNA.
DR EMBL; AF188333; AAF15588.1; -; mRNA.
DR AlphaFoldDB; Q9QXQ7; -.
DR SMR; Q9QXQ7; -.
DR STRING; 10116.ENSRNOP00000021164; -.
DR GlyGen; Q9QXQ7; 4 sites.
DR PaxDb; Q9QXQ7; -.
DR UCSC; RGD:69250; rat.
DR RGD; 69250; Wnt5a.
DR eggNOG; KOG3913; Eukaryota.
DR InParanoid; Q9QXQ7; -.
DR PhylomeDB; Q9QXQ7; -.
DR Reactome; R-RNO-201681; TCF dependent signaling in response to WNT.
DR Reactome; R-RNO-3238698; WNT ligand biogenesis and trafficking.
DR Reactome; R-RNO-4086398; Ca2+ pathway.
DR Reactome; R-RNO-4086400; PCP/CE pathway.
DR Reactome; R-RNO-4608870; Asymmetric localization of PCP proteins.
DR Reactome; R-RNO-5099900; WNT5A-dependent internalization of FZD4.
DR Reactome; R-RNO-5140745; WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
DR Reactome; R-RNO-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-RNO-8856828; Clathrin-mediated endocytosis.
DR PRO; PR:Q9QXQ7; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0009986; C:cell surface; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR GO; GO:0031012; C:extracellular matrix; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0098978; C:glutamatergic synapse; ISO:RGD.
DR GO; GO:0098794; C:postsynapse; IEA:GOC.
DR GO; GO:1902379; F:chemoattractant activity involved in axon guidance; ISO:RGD.
DR GO; GO:0005125; F:cytokine activity; ISO:RGD.
DR GO; GO:0005109; F:frizzled binding; ISO:RGD.
DR GO; GO:0019904; F:protein domain specific binding; ISO:RGD.
DR GO; GO:0005115; F:receptor tyrosine kinase-like orphan receptor binding; ISO:RGD.
DR GO; GO:0005102; F:signaling receptor binding; ISO:RGD.
DR GO; GO:0090630; P:activation of GTPase activity; ISO:RGD.
DR GO; GO:0032148; P:activation of protein kinase B activity; ISO:RGD.
DR GO; GO:0001667; P:ameboidal-type cell migration; ISO:RGD.
DR GO; GO:0008595; P:anterior/posterior axis specification, embryo; ISO:RGD.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR GO; GO:0003283; P:atrial septum development; ISO:RGD.
DR GO; GO:0003401; P:axis elongation; ISO:RGD.
DR GO; GO:0007411; P:axon guidance; ISO:RGD.
DR GO; GO:0007409; P:axonogenesis; ISO:RGD.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; ISO:RGD.
DR GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEP:RGD.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; ISO:RGD.
DR GO; GO:0071277; P:cellular response to calcium ion; ISO:RGD.
DR GO; GO:0071346; P:cellular response to interferon-gamma; ISO:RGD.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:RGD.
DR GO; GO:0071219; P:cellular response to molecule of bacterial origin; ISO:RGD.
DR GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; ISO:RGD.
DR GO; GO:0060067; P:cervix development; ISO:RGD.
DR GO; GO:0036517; P:chemoattraction of serotonergic neuron axon; ISO:RGD.
DR GO; GO:0036518; P:chemorepulsion of dopaminergic neuron axon; ISO:RGD.
DR GO; GO:0090103; P:cochlea morphogenesis; ISO:RGD.
DR GO; GO:0060026; P:convergent extension; ISO:RGD.
DR GO; GO:0060028; P:convergent extension involved in axis elongation; ISO:RGD.
DR GO; GO:0060029; P:convergent extension involved in organogenesis; ISO:RGD.
DR GO; GO:0007368; P:determination of left/right symmetry; ISO:RGD.
DR GO; GO:0046546; P:development of primary male sexual characteristics; ISO:RGD.
DR GO; GO:0048546; P:digestive tract morphogenesis; ISO:RGD.
DR GO; GO:0071542; P:dopaminergic neuron differentiation; ISO:RGD.
DR GO; GO:0042733; P:embryonic digit morphogenesis; ISO:RGD.
DR GO; GO:0030326; P:embryonic limb morphogenesis; ISO:RGD.
DR GO; GO:0048706; P:embryonic skeletal system development; ISO:RGD.
DR GO; GO:0060750; P:epithelial cell proliferation involved in mammary gland duct elongation; ISO:RGD.
DR GO; GO:0001837; P:epithelial to mesenchymal transition; ISO:RGD.
DR GO; GO:0045198; P:establishment of epithelial cell apical/basal polarity; ISO:RGD.
DR GO; GO:0001736; P:establishment of planar polarity; ISO:RGD.
DR GO; GO:0044849; P:estrous cycle; IEP:RGD.
DR GO; GO:0060324; P:face development; ISO:RGD.
DR GO; GO:0048806; P:genitalia development; ISO:RGD.
DR GO; GO:0001947; P:heart looping; ISO:RGD.
DR GO; GO:0071425; P:hematopoietic stem cell proliferation; ISO:RGD.
DR GO; GO:0007442; P:hindgut morphogenesis; ISO:RGD.
DR GO; GO:0048850; P:hypophysis morphogenesis; ISO:RGD.
DR GO; GO:0042472; P:inner ear morphogenesis; ISO:RGD.
DR GO; GO:0007254; P:JNK cascade; ISO:RGD.
DR GO; GO:0030216; P:keratinocyte differentiation; ISO:RGD.
DR GO; GO:0001822; P:kidney development; ISO:RGD.
DR GO; GO:0060599; P:lateral sprouting involved in mammary gland duct morphogenesis; ISO:RGD.
DR GO; GO:0035108; P:limb morphogenesis; ISO:RGD.
DR GO; GO:0048286; P:lung alveolus development; IEP:RGD.
DR GO; GO:0030324; P:lung development; ISO:RGD.
DR GO; GO:0008584; P:male gonad development; ISO:RGD.
DR GO; GO:0060744; P:mammary gland branching involved in thelarche; ISO:RGD.
DR GO; GO:0097325; P:melanocyte proliferation; ISO:RGD.
DR GO; GO:0060638; P:mesenchymal-epithelial cell signaling; ISO:RGD.
DR GO; GO:0060809; P:mesodermal to mesenchymal transition involved in gastrulation; ISO:RGD.
DR GO; GO:0030901; P:midbrain development; ISO:RGD.
DR GO; GO:1904948; P:midbrain dopaminergic neuron differentiation; ISO:RGD.
DR GO; GO:0007494; P:midgut development; ISO:RGD.
DR GO; GO:0002009; P:morphogenesis of an epithelium; ISO:RGD.
DR GO; GO:0050919; P:negative chemotaxis; ISO:RGD.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:RGD.
DR GO; GO:0048843; P:negative regulation of axon extension involved in axon guidance; ISO:RGD.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; ISO:RGD.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISO:RGD.
DR GO; GO:1904934; P:negative regulation of cell proliferation in midbrain; ISO:RGD.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISO:RGD.
DR GO; GO:0045599; P:negative regulation of fat cell differentiation; ISO:RGD.
DR GO; GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; ISO:RGD.
DR GO; GO:0048022; P:negative regulation of melanin biosynthetic process; ISO:RGD.
DR GO; GO:0072201; P:negative regulation of mesenchymal cell proliferation; ISO:RGD.
DR GO; GO:0060686; P:negative regulation of prostatic bud formation; ISO:RGD.
DR GO; GO:0051964; P:negative regulation of synapse assembly; ISO:RGD.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0001843; P:neural tube closure; ISO:RGD.
DR GO; GO:0021915; P:neural tube development; ISO:RGD.
DR GO; GO:0022008; P:neurogenesis; ISO:RGD.
DR GO; GO:0030182; P:neuron differentiation; IEP:RGD.
DR GO; GO:0048812; P:neuron projection morphogenesis; ISO:RGD.
DR GO; GO:0035567; P:non-canonical Wnt signaling pathway; ISO:RGD.
DR GO; GO:0038031; P:non-canonical Wnt signaling pathway via JNK cascade; ISO:RGD.
DR GO; GO:0048570; P:notochord morphogenesis; ISO:RGD.
DR GO; GO:0021891; P:olfactory bulb interneuron development; ISO:RGD.
DR GO; GO:0048341; P:paraxial mesoderm formation; ISO:RGD.
DR GO; GO:0003344; P:pericardium morphogenesis; ISO:RGD.
DR GO; GO:0003402; P:planar cell polarity pathway involved in axis elongation; ISO:RGD.
DR GO; GO:1904938; P:planar cell polarity pathway involved in axon guidance; ISO:RGD.
DR GO; GO:0061350; P:planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; ISO:RGD.
DR GO; GO:0061349; P:planar cell polarity pathway involved in cardiac right atrium morphogenesis; ISO:RGD.
DR GO; GO:0060775; P:planar cell polarity pathway involved in gastrula mediolateral intercalation; ISO:RGD.
DR GO; GO:0090179; P:planar cell polarity pathway involved in neural tube closure; ISO:RGD.
DR GO; GO:0061347; P:planar cell polarity pathway involved in outflow tract morphogenesis; ISO:RGD.
DR GO; GO:0061354; P:planar cell polarity pathway involved in pericardium morphogenesis; ISO:RGD.
DR GO; GO:0061348; P:planar cell polarity pathway involved in ventricular septum morphogenesis; ISO:RGD.
DR GO; GO:0045766; P:positive regulation of angiogenesis; ISO:RGD.
DR GO; GO:0061036; P:positive regulation of cartilage development; ISO:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0022409; P:positive regulation of cell-cell adhesion; IMP:RGD.
DR GO; GO:2000049; P:positive regulation of cell-cell adhesion mediated by cadherin; ISO:RGD.
DR GO; GO:0032722; P:positive regulation of chemokine production; ISO:RGD.
DR GO; GO:0001819; P:positive regulation of cytokine production; ISO:RGD.
DR GO; GO:0002720; P:positive regulation of cytokine production involved in immune response; ISO:RGD.
DR GO; GO:0045807; P:positive regulation of endocytosis; ISO:RGD.
DR GO; GO:0010595; P:positive regulation of endothelial cell migration; ISO:RGD.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISO:RGD.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISO:RGD.
DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; ISO:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR GO; GO:0043547; P:positive regulation of GTPase activity; ISO:RGD.
DR GO; GO:0090082; P:positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway; ISO:RGD.
DR GO; GO:0050729; P:positive regulation of inflammatory response; ISO:RGD.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; ISO:RGD.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; ISO:RGD.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; ISO:RGD.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:RGD.
DR GO; GO:0046330; P:positive regulation of JNK cascade; ISO:RGD.
DR GO; GO:0043507; P:positive regulation of JUN kinase activity; ISO:RGD.
DR GO; GO:0043032; P:positive regulation of macrophage activation; ISO:RGD.
DR GO; GO:0060907; P:positive regulation of macrophage cytokine production; ISO:RGD.
DR GO; GO:0045836; P:positive regulation of meiotic nuclear division; ISO:RGD.
DR GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; ISO:RGD.
DR GO; GO:1901216; P:positive regulation of neuron death; ISO:RGD.
DR GO; GO:0150012; P:positive regulation of neuron projection arborization; IGI:ARUK-UCL.
DR GO; GO:0010976; P:positive regulation of neuron projection development; ISO:RGD.
DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISO:RGD.
DR GO; GO:2000052; P:positive regulation of non-canonical Wnt signaling pathway; ISO:RGD.
DR GO; GO:0045778; P:positive regulation of ossification; ISO:RGD.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:RGD.
DR GO; GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; ISO:RGD.
DR GO; GO:0032092; P:positive regulation of protein binding; ISO:RGD.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; ISO:RGD.
DR GO; GO:0045860; P:positive regulation of protein kinase activity; ISO:RGD.
DR GO; GO:1900020; P:positive regulation of protein kinase C activity; ISO:RGD.
DR GO; GO:0090037; P:positive regulation of protein kinase C signaling; ISO:RGD.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:RGD.
DR GO; GO:0060760; P:positive regulation of response to cytokine stimulus; ISO:RGD.
DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; ISO:RGD.
DR GO; GO:0070245; P:positive regulation of thymocyte apoptotic process; ISO:RGD.
DR GO; GO:0051885; P:positive regulation of timing of anagen; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISO:RGD.
DR GO; GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; ISO:RGD.
DR GO; GO:0036342; P:post-anal tail morphogenesis; ISO:RGD.
DR GO; GO:0003138; P:primary heart field specification; ISO:RGD.
DR GO; GO:0090009; P:primitive streak formation; ISO:RGD.
DR GO; GO:0030850; P:prostate gland development; IEP:RGD.
DR GO; GO:0006468; P:protein phosphorylation; ISO:RGD.
DR GO; GO:0060762; P:regulation of branching involved in mammary gland duct morphogenesis; ISO:RGD.
DR GO; GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; ISO:RGD.
DR GO; GO:0099175; P:regulation of postsynapse organization; ISO:RGD.
DR GO; GO:0099566; P:regulation of postsynaptic cytosolic calcium ion concentration; ISO:RGD.
DR GO; GO:0032880; P:regulation of protein localization; ISO:RGD.
DR GO; GO:0050807; P:regulation of synapse organization; ISO:RGD.
DR GO; GO:0032355; P:response to estradiol; IEP:RGD.
DR GO; GO:0051384; P:response to glucocorticoid; IEP:RGD.
DR GO; GO:0055093; P:response to hyperoxia; IEP:RGD.
DR GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR GO; GO:0010033; P:response to organic substance; IEP:RGD.
DR GO; GO:1905235; P:response to quercetin; IEP:RGD.
DR GO; GO:0033574; P:response to testosterone; IEP:RGD.
DR GO; GO:0003139; P:secondary heart field specification; ISO:RGD.
DR GO; GO:0062009; P:secondary palate development; ISO:RGD.
DR GO; GO:0061053; P:somite development; ISO:RGD.
DR GO; GO:0001756; P:somitogenesis; ISO:RGD.
DR GO; GO:0060606; P:tube closure; ISO:RGD.
DR GO; GO:0003323; P:type B pancreatic cell development; ISO:RGD.
DR GO; GO:0060157; P:urinary bladder development; ISO:RGD.
DR GO; GO:0060065; P:uterus development; ISO:RGD.
DR GO; GO:0060068; P:vagina development; ISO:RGD.
DR GO; GO:0003281; P:ventricular septum development; ISO:RGD.
DR GO; GO:0016055; P:Wnt signaling pathway; ISO:RGD.
DR GO; GO:1904953; P:Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; ISO:RGD.
DR GO; GO:0007223; P:Wnt signaling pathway, calcium modulating pathway; ISO:RGD.
DR GO; GO:0060071; P:Wnt signaling pathway, planar cell polarity pathway; IDA:MGI.
DR GO; GO:0042060; P:wound healing; ISO:RGD.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR026538; Wnt5a.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027; PTHR12027; 1.
DR PANTHER; PTHR12027:SF33; PTHR12027:SF33; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 2: Evidence at transcript level;
KW Chondrogenesis; Developmental protein; Differentiation; Disulfide bond;
KW Extracellular matrix; Glycoprotein; Lipoprotein; Reference proteome;
KW Secreted; Signal; Wnt signaling pathway.
FT SIGNAL 1..37
FT /evidence="ECO:0000255"
FT PROPEP 38..61
FT /evidence="ECO:0000250"
FT /id="PRO_0000352798"
FT CHAIN 62..380
FT /note="Protein Wnt-5a"
FT /id="PRO_0000041429"
FT LIPID 244
FT /note="O-palmitoleoyl serine; by PORCN"
FT /evidence="ECO:0000250|UniProtKB:P56704"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 120
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 312
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 326
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..115
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 154..162
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 164..182
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 238..252
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 240..247
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 309..340
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 325..335
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 339..379
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 355..370
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 357..367
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 362..363
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT CONFLICT 42
FT /note="E -> K (in Ref. 2; AAF15588)"
FT /evidence="ECO:0000305"
FT CONFLICT 50
FT /note="G -> S (in Ref. 2; AAF15588)"
FT /evidence="ECO:0000305"
FT CONFLICT 61
FT /note="H -> Y (in Ref. 2; AAF15588)"
FT /evidence="ECO:0000305"
FT CONFLICT 168
FT /note="Missing (in Ref. 2; AAF15588)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 380 AA; 42283 MW; 9716401010072224 CRC64;
MKKPIGILSP GVALGTAGGA MSSKFFLMAL ATFFSFAQVV IEANSWWSLG MNNPVQMSEV
HIIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG IKECQYQFRH RRWNCSTVDN
TSVFGRVMQI GSRETAFTYA VSAAGVVNAM SRACREGELS TCGCSRAARP KDLPRDWLWG
GCGDNIDYGY RFAKEFVDAR ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC
HGVSGSCSLK TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV
YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV QTERCHCKFH
WCCYVKCKKC TEIVDQFVCK
