ID   WNT5_HALRO              Reviewed;         363 AA.
AC   O15978;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Protein Wnt-5;
DE   Flags: Precursor;
GN   Name=WNT5;
OS   Halocynthia roretzi (Sea squirt) (Cynthia roretzi).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Stolidobranchia;
OC   Pyuridae; Halocynthia.
OX   NCBI_TaxID=7729;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Sasakura Y., Ogasawara M., Makabe K.W.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ligand for members of the frizzled family of seven
CC       transmembrane receptors. Probable developmental protein. May be a
CC       signaling molecule which affects the development of discrete regions of
CC       tissues. Is likely to signal over only few cell diameters (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix.
CC   -!- PTM: Palmitoleoylation is required for efficient binding to frizzled
CC       receptors. Depalmitoleoylation leads to Wnt signaling pathway
CC       inhibition. {ECO:0000250|UniProtKB:P27467,
CC       ECO:0000250|UniProtKB:P56704}.
CC   -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
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DR   EMBL; AB006608; BAA21878.1; -; Genomic_DNA.
DR   AlphaFoldDB; O15978; -.
DR   SMR; O15978; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2460.20; -; 1.
DR   InterPro; IPR005817; Wnt.
DR   InterPro; IPR043158; Wnt_C.
DR   InterPro; IPR018161; Wnt_CS.
DR   PANTHER; PTHR12027; PTHR12027; 1.
DR   Pfam; PF00110; wnt; 1.
DR   PRINTS; PR01349; WNTPROTEIN.
DR   SMART; SM00097; WNT1; 1.
DR   PROSITE; PS00246; WNT1; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Disulfide bond; Extracellular matrix; Glycoprotein;
KW   Lipoprotein; Secreted; Signal; Wnt signaling pathway.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..363
FT                   /note="Protein Wnt-5"
FT                   /id="PRO_0000041439"
FT   LIPID           227
FT                   /note="O-palmitoleoyl serine; by PORCN"
FT                   /evidence="ECO:0000250|UniProtKB:P56704"
FT   CARBOHYD        48
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        98
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        88..99
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        137..145
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        147..165
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        221..235
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        223..230
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        292..323
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        308..318
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        322..362
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        338..353
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        340..350
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        345..346
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
SQ   SEQUENCE   363 AA;  40828 MW;  79A820F8796527B9 CRC64;
     MVGMTRIQSA EPVWILFVLT LYSSVLMQVK PQLWSVGIER KKLFGETNTS VHCDEIRGLS
     RNQRSLCRTY NDHMYYVESG SKQGVEECQW QFRGQRWNCS LASNASPDKI IAVGSKETAF
     TYAITSGGVV QSIARACKSG NLMACGCSKR ERPTGLGKDW NWGGCGDDID YAYGFAHEFI
     DAQERDNSSP NDRRVKSHKA MNIHNNEAGR LSVVRASHTT CKCHGVSGSC SIKTCWLQTP
     QFRTIGDKLR QRYDDALEMR VTHRGQMKTR FSSDRNPSNI DLVYIDSSPD YCKVNHKLGI
     LGTSGRECQL DSLAMDGCGL MCCGRGYTTK MVEVVKSCNC KFQWCCFVKC QQCKEKVLKH
     ICN