ID   WNT7A_XENLA             Reviewed;         135 AA.
AC   P31288;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Protein Wnt-7a;
DE            Short=XWnt-7a;
DE   Flags: Fragment;
GN   Name=wnt7a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX   PubMed=1408135;
RA   Wolda S.L., Moon R.T.;
RT   "Cloning and developmental expression in Xenopus laevis of seven additional
RT   members of the Wnt family.";
RL   Oncogene 7:1941-1947(1992).
CC   -!- FUNCTION: Ligand for members of the frizzled family of seven
CC       transmembrane receptors that functions in the canonical Wnt/beta-
CC       catenin signaling pathway (By similarity). Plays an important role in
CC       embryonic development, including dorsal versus ventral patterning
CC       during limb development, skeleton development and urogenital tract
CC       development. Required for central nervous system (CNS) angiogenesis and
CC       blood-brain barrier regulation (By similarity).
CC       {ECO:0000250|UniProtKB:O00755, ECO:0000250|UniProtKB:P24383}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250|UniProtKB:P24383}. Secreted
CC       {ECO:0000250|UniProtKB:P24383}.
CC   -!- TISSUE SPECIFICITY: In embryo, in brain and ventral neural tube; in
CC       adults, in brain. {ECO:0000269|PubMed:1408135}.
CC   -!- DEVELOPMENTAL STAGE: Tailbud onwards. {ECO:0000269|PubMed:1408135}.
CC   -!- PTM: Palmitoleoylation is required for efficient binding to frizzled
CC       receptors. Depalmitoleoylation leads to Wnt signaling pathway
CC       inhibition. {ECO:0000250|UniProtKB:P27467,
CC       ECO:0000250|UniProtKB:P56704}.
CC   -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
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DR   EMBL; L07533; AAA49986.1; -; mRNA.
DR   AlphaFoldDB; P31288; -.
DR   SMR; P31288; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR   GO; GO:0009888; P:tissue development; IEA:UniProt.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR005817; Wnt.
DR   InterPro; IPR013300; Wnt7.
DR   InterPro; IPR018161; Wnt_CS.
DR   PANTHER; PTHR12027; PTHR12027; 1.
DR   Pfam; PF00110; wnt; 1.
DR   PRINTS; PR01891; WNT7PROTEIN.
DR   PRINTS; PR01349; WNTPROTEIN.
DR   SMART; SM00097; WNT1; 1.
DR   PROSITE; PS00246; WNT1; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Disulfide bond; Extracellular matrix; Glycoprotein;
KW   Lipoprotein; Reference proteome; Secreted; Wnt signaling pathway.
FT   CHAIN           <1..>135
FT                   /note="Protein Wnt-7a"
FT                   /id="PRO_0000200649"
FT   REGION          41..69
FT                   /note="Disordered linker"
FT                   /evidence="ECO:0000250|UniProtKB:O00755"
FT   LIPID           9
FT                   /note="O-palmitoleoyl serine; by PORCN"
FT                   /evidence="ECO:0000250|UniProtKB:P56704"
FT   CARBOHYD        98
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        3..17
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        5..12
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        81..112
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        97..107
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        111..134
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        130..131
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   CONFLICT        127..131
FT                   /note="Missing (in Ref. 1; AAA49986)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         135
SQ   SEQUENCE   135 AA;  15563 MW;  F49B870AFA1F962C CRC64;
     QECKCHGVSG SCTTKTCWTT LPKFRELGFI VKDKYKEAVQ VEPVRASRNK RPTFLKIKKP
     LSYRKPMDTD LVYIEKSPNY CEEDPMTGSM GTQGRLCNKT AQHTSGCDLM CCGRGYNTHQ
     YSRVWQFHWC CCNCK