WNT7B_CHICK
ID WNT7B_CHICK Reviewed; 349 AA.
AC Q3L254; Q3L253;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Protein Wnt-7b;
DE Flags: Precursor;
GN Name=WNT7B;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RX PubMed=16258938; DOI=10.1002/dvdy.20621;
RA Fokina V.M., Frolova E.I.;
RT "Expression patterns of Wnt genes during development of an anterior part of
RT the chicken eye.";
RL Dev. Dyn. 235:496-505(2006).
RN [2]
RP ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), AND DEVELOPMENTAL STAGE.
RX PubMed=7577679; DOI=10.1016/0925-4773(95)00385-e;
RA Hollyday M., McMahon J.A., McMahon A.P.;
RT "Wnt expression patterns in chick embryo nervous system.";
RL Mech. Dev. 52:9-25(1995).
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors that functions in the canonical Wnt/beta-
CC catenin signaling pathway (By similarity). Required for normal fusion
CC of the chorion and the allantois during placenta development (By
CC similarity). Required for central nervous system (CNS) angiogenesis and
CC blood-brain barrier regulation (By similarity).
CC {ECO:0000250|UniProtKB:P28047, ECO:0000250|UniProtKB:P56706}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250|UniProtKB:P56706}. Secreted
CC {ECO:0000250|UniProtKB:P56706}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3L254-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3L254-2; Sequence=VSP_038847;
CC -!- TISSUE SPECIFICITY: Expressed in differentiating lens fiber cells.
CC {ECO:0000269|PubMed:16258938}.
CC -!- DEVELOPMENTAL STAGE: Detected in the anterior parencephalon and
CC secondary prosencephalon at stages 20 and 24. Expressed in the
CC ventricular epithelium of the spinal cord at the latest stages.
CC {ECO:0000269|PubMed:7577679}.
CC -!- PTM: Palmitoleoylation is required for efficient binding to frizzled
CC receptors. Depalmitoleoylation leads to Wnt signaling pathway
CC inhibition. {ECO:0000250|UniProtKB:P27467,
CC ECO:0000250|UniProtKB:P56704}.
CC -!- MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
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DR EMBL; AY753290; AAW81992.1; -; mRNA.
DR EMBL; AY753291; AAW81993.1; -; mRNA.
DR RefSeq; NP_001032351.1; NM_001037274.1. [Q3L254-1]
DR RefSeq; NP_001165064.1; NM_001171593.1. [Q3L254-2]
DR AlphaFoldDB; Q3L254; -.
DR SMR; Q3L254; -.
DR STRING; 9031.ENSGALP00000041983; -.
DR PaxDb; Q3L254; -.
DR PRIDE; Q3L254; -.
DR Ensembl; ENSGALT00000048993; ENSGALP00000046960; ENSGALG00000036255. [Q3L254-2]
DR Ensembl; ENSGALT00000050637; ENSGALP00000048489; ENSGALG00000036255. [Q3L254-1]
DR GeneID; 427937; -.
DR KEGG; gga:427937; -.
DR CTD; 7477; -.
DR VEuPathDB; HostDB:geneid_427937; -.
DR eggNOG; KOG3913; Eukaryota.
DR GeneTree; ENSGT00940000158861; -.
DR InParanoid; Q3L254; -.
DR OMA; VHCETCT; -.
DR OrthoDB; 745245at2759; -.
DR PhylomeDB; Q3L254; -.
DR TreeFam; TF105310; -.
DR Reactome; R-GGA-3238698; WNT ligand biogenesis and trafficking.
DR PRO; PR:Q3L254; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000036255; Expressed in cerebellum and 1 other tissue.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005109; F:frizzled binding; IBA:GO_Central.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0070307; P:lens fiber cell development; IEP:BHF-UCL.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR013300; Wnt7.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027; PTHR12027; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01891; WNT7PROTEIN.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; Disulfide bond;
KW Extracellular matrix; Glycoprotein; Lipoprotein; Reference proteome;
KW Secreted; Signal; Wnt signaling pathway.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..349
FT /note="Protein Wnt-7b"
FT /id="PRO_0000392674"
FT REGION 238..266
FT /note="Disordered linker"
FT /evidence="ECO:0000250|UniProtKB:P56706"
FT LIPID 206
FT /note="O-palmitoleoyl serine; by PORCN"
FT /evidence="ECO:0000250|UniProtKB:P56704"
FT CARBOHYD 83
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 295
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 73..84
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 123..131
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 133..152
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 200..214
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 202..209
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 278..309
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 294..304
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 308..348
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 324..339
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 326..336
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT DISULFID 331..332
FT /evidence="ECO:0000250|UniProtKB:P28026"
FT VAR_SEQ 1..24
FT /note="MHRNFRKWIFYVFLCFGVIYVKLG -> MILFSSRSVLLSVYYPQIFLILTS
FT GSYL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16258938"
FT /id="VSP_038847"
SQ SEQUENCE 349 AA; 39530 MW; 7E65DDBB1F069B83 CRC64;
MHRNFRKWIF YVFLCFGVIY VKLGALSSVV ALGANIICNK IPGLAPRQRA ICQSRPDAII
VIGEGAQMGI NECQYQFRYG RWNCSALGEK TVFGQELRVG SREAAFTYAI TAAGVAHAVT
AACSQGNLSN CGCDREKQGY YNQEEGWKWG GCSADIRYGI EFSRRFVDAR EIKKNARRLM
NLHNNEAGRK VLEERMKLEC KCHGVSGSCT TKTCWTTLPK FREIGYILKE KYNAAVQVEV
VRASRLRQPT FLKIKQIKSY QKPMETDLVY IEKSPNYCEE DASTGSVGTQ GRLCNRTSPN
ADGCDMMCCG RGYNTHQYTK VWQCNCKFHW CCFVKCNTCS ERTEVFTCK
