ID   WNT7B_XENLA             Reviewed;         135 AA.
AC   P31289;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Protein Wnt-7b;
DE            Short=XWnt-7b;
DE   Flags: Fragment;
GN   Name=wnt7b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=1408135;
RA   Wolda S.L., Moon R.T.;
RT   "Cloning and developmental expression in Xenopus laevis of seven additional
RT   members of the Wnt family.";
RL   Oncogene 7:1941-1947(1992).
CC   -!- FUNCTION: Ligand for members of the frizzled family of seven
CC       transmembrane receptors that functions in the canonical Wnt/beta-
CC       catenin signaling pathway (By similarity). Required for normal fusion
CC       of the chorion and the allantois during placenta development (By
CC       similarity). Required for central nervous system (CNS) angiogenesis and
CC       blood-brain barrier regulation (By similarity).
CC       {ECO:0000250|UniProtKB:P28047, ECO:0000250|UniProtKB:P56706}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250|UniProtKB:P56706}. Secreted
CC       {ECO:0000250|UniProtKB:P56706}.
CC   -!- TISSUE SPECIFICITY: In adults, in brain and lung.
CC       {ECO:0000269|PubMed:1408135}.
CC   -!- DEVELOPMENTAL STAGE: Tailbud onwards. {ECO:0000269|PubMed:1408135}.
CC   -!- PTM: Palmitoleoylation is required for efficient binding to frizzled
CC       receptors. Depalmitoleoylation leads to Wnt signaling pathway
CC       inhibition. {ECO:0000250|UniProtKB:P27467,
CC       ECO:0000250|UniProtKB:P56704}.
CC   -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
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DR   EMBL; L07534; AAA49987.1; -; mRNA.
DR   PIR; I51576; I51576.
DR   AlphaFoldDB; P31289; -.
DR   SMR; P31289; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR   GO; GO:0009888; P:tissue development; IEA:UniProt.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2460.20; -; 1.
DR   InterPro; IPR005817; Wnt.
DR   InterPro; IPR013300; Wnt7.
DR   InterPro; IPR043158; Wnt_C.
DR   InterPro; IPR018161; Wnt_CS.
DR   PANTHER; PTHR12027; PTHR12027; 1.
DR   Pfam; PF00110; wnt; 1.
DR   PRINTS; PR01891; WNT7PROTEIN.
DR   PRINTS; PR01349; WNTPROTEIN.
DR   SMART; SM00097; WNT1; 1.
DR   PROSITE; PS00246; WNT1; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Disulfide bond; Extracellular matrix; Glycoprotein;
KW   Lipoprotein; Reference proteome; Secreted; Wnt signaling pathway.
FT   CHAIN           <1..>135
FT                   /note="Protein Wnt-7b"
FT                   /id="PRO_0000200654"
FT   REGION          41..69
FT                   /note="Disordered linker"
FT                   /evidence="ECO:0000250|UniProtKB:P56706"
FT   LIPID           9
FT                   /note="O-palmitoleoyl serine; by PORCN"
FT                   /evidence="ECO:0000250|UniProtKB:P56704"
FT   CARBOHYD        98
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        3..17
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        5..12
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        81..112
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        97..107
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   DISULFID        134..135
FT                   /evidence="ECO:0000250|UniProtKB:P28026"
FT   NON_TER         1
FT   NON_TER         135
SQ   SEQUENCE   135 AA;  15613 MW;  033485E57F34E0F9 CRC64;
     QECKCHGVSG SCTTKTCWNT LPKFREIGFV LKEKYNDAVH VEVVRANRLR QPTFLKIKKV
     RSYQKPMETD LVYIERSPNY CEEDSTTGSV GTQGRLCNRT SPHTDGCDLM CCGRGYNTHQ
     YTKVWQCNCK FHWCC