ID   WNTG_MANSE              Reviewed;         141 AA.
AC   Q25533;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Protein wingless;
DE   Flags: Fragment;
GN   Name=WG;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Embryo;
RX   PubMed=8022829; DOI=10.1073/pnas.91.14.6634;
RA   Kraft R., Jaeckle H.;
RT   "Drosophila mode of metamerization in the embryogenesis of the lepidopteran
RT   insect Manduca sexta.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:6634-6638(1994).
CC   -!- FUNCTION: Segment polarity protein. Binds to the frizzled seven-
CC       transmembrane receptors. This protein is probably a growth factor (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix.
CC   -!- DEVELOPMENTAL STAGE: Transcription is first detected just prior to
CC       gastrulation.
CC   -!- PTM: Palmitoleoylated by porcupine. The lipid group functions as a
CC       sorting signal, targeting the ligand to polarized vesicles that
CC       transport wg to unique sites at the cell surface. Depalmitoleoylated by
CC       notum, leading to inhibit Wnt signaling pathway.
CC       {ECO:0000250|UniProtKB:P09615}.
CC   -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
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DR   EMBL; Z30280; CAA82954.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q25533; -.
DR   SMR; Q25533; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0007367; P:segment polarity determination; IEA:UniProtKB-KW.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2460.20; -; 1.
DR   InterPro; IPR005817; Wnt.
DR   InterPro; IPR043158; Wnt_C.
DR   PANTHER; PTHR12027; PTHR12027; 1.
DR   Pfam; PF00110; wnt; 1.
DR   SMART; SM00097; WNT1; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Disulfide bond; Extracellular matrix; Glycoprotein;
KW   Lipoprotein; Secreted; Segmentation polarity protein;
KW   Wnt signaling pathway.
FT   CHAIN           <1..>141
FT                   /note="Protein wingless"
FT                   /id="PRO_0000200667"
FT   REGION          40..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           3
FT                   /note="O-palmitoleoyl serine; by PORCN"
FT                   /evidence="ECO:0000250|UniProtKB:P56704"
FT   CARBOHYD        108
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        138
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        107..122
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
FT   NON_TER         141
SQ   SEQUENCE   141 AA;  15639 MW;  8FFB52477407AF75 CRC64;
     GMSGSCTVKT CWMRLPSFRS VGDALKDRFD GASRVMVSNT DLEAPTQRND AAPHRAPRRE
     RYKLKLQPHN PDHKSPGSKD LVYLEPSPGF CEKNPRLGIP GTHGRACNDT SIGVDGCDLM
     CCGRGYRTET MFVVERCNCT F