ID   WOR1_FUSO4              Reviewed;         330 AA.
AC   J9N5P9;
DT   07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2012, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Global transcription regulator sge1 {ECO:0000305};
DE   AltName: Full=Six gene expression protein 1 {ECO:0000303|PubMed:19851506};
GN   Name=sge1 {ECO:0000303|PubMed:19851506}; ORFNames=FOXG_10510;
OS   Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935
OS   / NRRL 34936) (Fusarium vascular wilt of tomato).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium oxysporum species complex.
OX   NCBI_TaxID=426428;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4287 / CBS 123668 / FGSC 9935 / NRRL 34936;
RX   PubMed=20237561; DOI=10.1038/nature08850;
RA   Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA   Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA   Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA   Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA   Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA   Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA   Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA   Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA   Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA   Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA   Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA   Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT   "Comparative genomics reveals mobile pathogenicity chromosomes in
RT   Fusarium.";
RL   Nature 464:367-373(2010).
RN   [2]
RP   FUNCTION, INDUCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=19851506; DOI=10.1371/journal.ppat.1000637;
RA   Michielse C.B., van Wijk R., Reijnen L., Manders E.M., Boas S., Olivain C.,
RA   Alabouvette C., Rep M.;
RT   "The nuclear protein Sge1 of Fusarium oxysporum is required for parasitic
RT   growth.";
RL   PLoS Pathog. 5:E1000637-E1000637(2009).
CC   -!- FUNCTION: Global transcriptional regulator of pathogenicity. Acts as an
CC       activator of parasitic growth. Not essential for colonization or
CC       penetration of the root surface, but required for expression of genes
CC       encoding effectors that are secreted during infection. Involved in
CC       conidiogenesis, but is not required for conidial fitness, overall
CC       (colony) morphology, vegetative growth or carbon source utilization.
CC       {ECO:0000269|PubMed:19851506}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19851506}.
CC   -!- INDUCTION: Expression is up-regulated during infection of tomato roots.
CC       {ECO:0000269|PubMed:19851506}.
CC   -!- SIMILARITY: Belongs to the MIT1/WOR1 family. {ECO:0000305}.
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DR   EMBL; AAXH01000631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_018248224.1; XM_018389881.1.
DR   AlphaFoldDB; J9N5P9; -.
DR   SMR; J9N5P9; -.
DR   STRING; 426428.J9N5P9; -.
DR   EnsemblFungi; FOXG_10510T0; FOXG_10510P0; FOXG_10510.
DR   GeneID; 28951982; -.
DR   KEGG; fox:FOXG_10510; -.
DR   VEuPathDB; FungiDB:FOXG_10510; -.
DR   HOGENOM; CLU_028895_3_0_1; -.
DR   OMA; EYNIFER; -.
DR   PHI-base; PHI:3168; -.
DR   Proteomes; UP000009097; Chromosome 7.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018608; Gti1/Pac2.
DR   PANTHER; PTHR28027; PTHR28027; 1.
DR   Pfam; PF09729; Gti1_Pac2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Virulence.
FT   CHAIN           1..330
FT                   /note="Global transcription regulator sge1"
FT                   /id="PRO_0000431524"
FT   REGION          93..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          239..306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..306
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   330 AA;  37842 MW;  DD71E24D5CE44137 CRC64;
     MSGTMPLQPT FYGFIGDTTD ALIIFEACLS GKLFHVPRRP HDRERQDLIK SGNIFVYEEH
     ASGIKRWTDS ISWSPSRILG NYLLYRELEK PFPPGEKKRA RGRNGKSTTQ SGGITKSRPR
     NSVPFQTGLE HGNEYTTVPS DDERHLVGSL VDSYDFKEQG LVKKTISITY QGVPHHLVSY
     YHVEDVKAGL LPSPVDDPRL RGVVPRTELL TGQNFRAPIE EAQHGTYLSG AYMPNMDHQY
     APIGFPTHTQ QPALQQQPQQ QPQPQHQPQL QYQPQPHQHQ PQLQYQPQQQ HQPQQQYRPQ
     PQHQPQLQYQ PQALHPTAHG YPQSYGQTWW