ID   WOR1_GIBF5              Reviewed;         333 AA.
AC   S0E3H0;
DT   07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2013, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Global transcription regulator sge1 {ECO:0000305};
GN   Name=sge1 {ECO:0000303|PubMed:25115968};
GN   ORFNames=FFUJ_07864 {ECO:0000312|EMBL:CCT69384.1};
OS   Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae
OS   and foot rot disease fungus) (Fusarium fujikuroi).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=1279085;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 195.34 / IMI 58289 / NRRL A-6831;
RX   PubMed=23825955; DOI=10.1371/journal.ppat.1003475;
RA   Wiemann P., Sieber C.M.K., von Bargen K.W., Studt L., Niehaus E.-M.,
RA   Espino J.J., Huss K., Michielse C.B., Albermann S., Wagner D.,
RA   Bergner S.V., Connolly L.R., Fischer A., Reuter G., Kleigrewe K., Bald T.,
RA   Wingfield B.D., Ophir R., Freeman S., Hippler M., Smith K.M., Brown D.W.,
RA   Proctor R.H., Muensterkoetter M., Freitag M., Humpf H.-U., Gueldener U.,
RA   Tudzynski B.;
RT   "Deciphering the cryptic genome: genome-wide analyses of the rice pathogen
RT   Fusarium fujikuroi reveal complex regulation of secondary metabolism and
RT   novel metabolites.";
RL   PLoS Pathog. 9:E1003475-E1003475(2013).
RN   [2]
RP   INDUCTION, SUBCELLULAR LOCATION, AND FUNCTION.
RX   PubMed=25115968; DOI=10.1111/1462-2920.12592;
RA   Michielse C.B., Studt L., Janevska S., Sieber C.M., Arndt B., Espino J.J.,
RA   Humpf H.U., Gueldener U., Tudzynski B.;
RT   "The global regulator FfSge1 is required for expression of secondary
RT   metabolite gene clusters but not for pathogenicity in Fusarium fujikuroi.";
RL   Environ. Microbiol. 17:2690-2708(2015).
CC   -!- FUNCTION: Global transcriptional regulator that acts as an activator of
CC       secondary metabolism. Required for expression of a yet uncharacterized
CC       secondary metabolism gene cluster containing a non-canonical non-
CC       ribosomal peptide synthetase. Not required for conidiogenesis nor for
CC       pathogenicity, but is involved in vegetative growth.
CC       {ECO:0000269|PubMed:25115968}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25115968}.
CC   -!- INDUCTION: Regulates its own expression in a negative feedback loop.
CC       {ECO:0000269|PubMed:25115968}.
CC   -!- SIMILARITY: Belongs to the MIT1/WOR1 family. {ECO:0000305}.
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DR   EMBL; HF679027; CCT69384.1; -; Genomic_DNA.
DR   AlphaFoldDB; S0E3H0; -.
DR   SMR; S0E3H0; -.
DR   STRING; 1279085.S0E3H0; -.
DR   EnsemblFungi; CCT69384; CCT69384; FFUJ_07864.
DR   VEuPathDB; FungiDB:FFUJ_07864; -.
DR   HOGENOM; CLU_028895_3_0_1; -.
DR   PHI-base; PHI:3210; -.
DR   Proteomes; UP000016800; Chromosome 5.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018608; Gti1/Pac2.
DR   PANTHER; PTHR28027; PTHR28027; 1.
DR   Pfam; PF09729; Gti1_Pac2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..333
FT                   /note="Global transcription regulator sge1"
FT                   /id="PRO_0000431522"
FT   REGION          93..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          241..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..122
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   333 AA;  37758 MW;  8F4F93E77E2F7A04 CRC64;
     MAGTMPLRPT YVGFVRDTTD ALLIFEACLS GTLSHVPRRP HDRERQDLIK SGNIFVYEEH
     ASGIKRWTDS ISWSPSRILG NYLLYRELEK PFPPGEKKRA RGRNGKSTTQ SGGISKARQR
     NTVPFPQGLE HGNEYPSVPS DDERHLVGSL VDSYDFKEQG LVKKTISITY QGVPHHLVSY
     YNVEDVKAGL LSGPSDDPRL RGVVPRTELM NGQNFRAPVE EAMGGSYMPS MVASIGYPTL
     QHQSQMHQSQ MHQPQMHQPQ MHQSQMHQSQ MHQPQMHQPQ AHQPQVHQPQ VHPPQVHQPQ
     AHQPQYQSQT LHPTHGYQQT YAGQPNAPSS TWW