WOR1_GIBZE
ID WOR1_GIBZE Reviewed; 342 AA.
AC I1S5P3; A0A098DAF4; A0A0E0RUJ1;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2012, sequence version 1.
DT 25-MAY-2022, entry version 45.
DE RecName: Full=Global transcription regulator FGP1 {ECO:0000305};
GN Name=FGP1 {ECO:0000303|PubMed:22693448}; ORFNames=FGRRES_12164, FGSG_12164;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
RN [4]
RP DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=22693448; DOI=10.1371/journal.ppat.1002724;
RA Jonkers W., Dong Y., Broz K., Kistler H.C.;
RT "The Wor1-like protein Fgp1 regulates pathogenicity, toxin synthesis and
RT reproduction in the phytopathogenic fungus Fusarium graminearum.";
RL PLoS Pathog. 8:E1002724-E1002724(2012).
CC -!- FUNCTION: Global transcriptional regulator of pathogenicity. Regulates
CC many genes during growth in putrescine medium and during infection.
CC Involved in the developmental processes of conidium formation and
CC sexual reproduction and modulates a morphological change that
CC accompanies mycotoxin production. {ECO:0000269|PubMed:22693448}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:J9N5P9}.
CC -!- DISRUPTION PHENOTYPE: Results in greatly reduced pathogenicity and loss
CC of trichothecene toxin accumulation in infected wheat plants. Exhibits
CC normal vegetative growth but shows defects in asexual and sexual spore
CC development. {ECO:0000269|PubMed:22693448}.
CC -!- SIMILARITY: Belongs to the MIT1/WOR1 family. {ECO:0000305}.
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DR EMBL; DS231663; ESU08050.1; -; Genomic_DNA.
DR EMBL; HG970332; CEF74916.1; -; Genomic_DNA.
DR RefSeq; XP_011318535.1; XM_011320233.1.
DR AlphaFoldDB; I1S5P3; -.
DR SMR; I1S5P3; -.
DR STRING; 5518.FGSG_12164P0; -.
DR EnsemblFungi; ESU08050; ESU08050; FGSG_12164.
DR GeneID; 23558979; -.
DR KEGG; fgr:FGSG_12164; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G06223; -.
DR eggNOG; KOG4476; Eukaryota.
DR HOGENOM; CLU_811462_0_0_1; -.
DR InParanoid; I1S5P3; -.
DR PHI-base; PHI:2399; -.
DR PHI-base; PHI:5253; -.
DR Proteomes; UP000070720; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR018608; Gti1/Pac2.
DR PANTHER; PTHR28027; PTHR28027; 1.
DR Pfam; PF09729; Gti1_Pac2; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Transcription; Transcription regulation;
KW Virulence.
FT CHAIN 1..342
FT /note="Global transcription regulator FGP1"
FT /id="PRO_0000431526"
FT REGION 91..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 342 AA; 37755 MW; CF2ACBBE0A164020 CRC64;
MANSVLTATY EGYIRDTADA LRIFEACLTG SLTHTARRPH DRERSTLITS GNVFVYEEGS
SGIKRWTDGV NWSPSRILGN FLVYREMNQP FSPGEKKRAS KKPKKQAGVA KAYDHRPQAT
RFSSMPNDPA GVCAGGDGGA GDEDRDLVGS LTDSYDFKPN SLIKKTISIT HNGIPHHLVS
YYTVDDVRSG RLVRPSDHEF FGRVQPRMEL MSGQNFRVPL EDGGDEESRG VMSHGQQVMP
YPCNDYQIFQ HAYGNAAAPR TGQFTYGPPQ NGTYAPVSVP ATHAIQNGTY APVSVPATPA
LQNGTYLPVP APQNGSYYNL HQNVHQNVHQ NPAYPWYHAQ LQ
