WOR3_CANAL
ID WOR3_CANAL Reviewed; 641 AA.
AC Q5A6T8; A0A1D8PSL0;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2017, sequence version 2.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=White-opaque regulator 3;
GN Name=WOR3; OrderedLocusNames=CAALFM_CR03890WA;
GN ORFNames=CaO19.467, CaO19.8098;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP INDUCTION.
RX PubMed=22265407; DOI=10.1016/j.cell.2011.10.048;
RA Nobile C.J., Fox E.P., Nett J.E., Sorrells T.R., Mitrovich Q.M.,
RA Hernday A.D., Tuch B.B., Andes D.R., Johnson A.D.;
RT "A recently evolved transcriptional network controls biofilm development in
RT Candida albicans.";
RL Cell 148:126-138(2012).
RN [5]
RP INDUCTION.
RX PubMed=23855748; DOI=10.1111/mmi.12329;
RA Hernday A.D., Lohse M.B., Fordyce P.M., Nobile C.J., DeRisi J.L.,
RA Johnson A.D.;
RT "Structure of the transcriptional network controlling white-opaque
RT switching in Candida albicans.";
RL Mol. Microbiol. 90:22-35(2013).
RN [6]
RP FUNCTION, DNA-BINDING, AND DISRUPTION PHENOTYPE.
RX PubMed=23610392; DOI=10.1073/pnas.1221734110;
RA Lohse M.B., Hernday A.D., Fordyce P.M., Noiman L., Sorrells T.R.,
RA Hanson-Smith V., Nobile C.J., DeRisi J.L., Johnson A.D.;
RT "Identification and characterization of a previously undescribed family of
RT sequence-specific DNA-binding domains.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:7660-7665(2013).
CC -!- FUNCTION: Transcription factor that modulates the white-opaque switch.
CC {ECO:0000269|PubMed:23610392}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- INDUCTION: Expression is induced in opaque cells and biofilm, and is
CC regulated by WOR1. {ECO:0000269|PubMed:22265407,
CC ECO:0000269|PubMed:23855748}.
CC -!- DISRUPTION PHENOTYPE: Stabilizes opaque cells at higher temperatures.
CC {ECO:0000269|PubMed:23610392}.
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DR EMBL; CP017630; AOW31127.1; -; Genomic_DNA.
DR RefSeq; XP_717331.2; XM_712238.2.
DR AlphaFoldDB; Q5A6T8; -.
DR BioGRID; 1223940; 2.
DR STRING; 237561.Q5A6T8; -.
DR PRIDE; Q5A6T8; -.
DR GeneID; 3641009; -.
DR KEGG; cal:CAALFM_CR03890WA; -.
DR CGD; CAL0000189623; WOR3.
DR VEuPathDB; FungiDB:CR_03890W_A; -.
DR eggNOG; ENOG502SNVY; Eukaryota.
DR HOGENOM; CLU_428921_0_0_1; -.
DR InParanoid; Q5A6T8; -.
DR OrthoDB; 1503829at2759; -.
DR PRO; PR:Q5A6T8; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR PROSITE; PS51128; ZF_DKSA_2; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..641
FT /note="White-opaque regulator 3"
FT /id="PRO_0000426093"
FT ZN_FING 317..337
FT /note="dksA C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00510"
FT REGION 13..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..499
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..608
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 641 AA; 73665 MW; D05A132B024367FE CRC64;
MDQTYLDQQQ LDANVNHQQL SQDTNSIPQQ QLQQQQQPLQ QLQQYQQQPL SNANFSGDNR
FQQYQPRVTP SVSSSQQSIH NTTGYVTMHS GNYTPNQQYG VPNQYTVLQQ QPPRQQSYEE
NINPLSYNSN YRTLSAPIPP LHIQHQLASK QNQDQNQSQN RYEQSSMTSI HTNDNSSSVN
NSPNTMMIKQ EHSTFQPQHS NEGSSAYHPV DQQNHQQQQQ PQQQQQPQQQ QQPQQQQQPQ
QPMTRSICTR CKKGFDQPII YPKSSNSTNG NNSNGQNSSS IPPPEPRTFK LCDHCRKLQR
QRSRRWQKKT KDREGVCRRC GSEIPLAERR FVLCPSCREN LRLRKASRAA QGRCVHCSGP
LDASILSKEN EGNNNGDEQN NKSNEDQNNE SRRGSQEKPA RGASHKVCQR CRENDKIRRA
NLEKMGNCNR CAKALDPNEY GRNKVCFNCR TKKKRSPPEN VTNTDEVRTS PIQNQYGMNM
SHQYIQPPPP PPPPLMTGHH QFQPQPHMMG HEQMNTFTTM SNSGVAGIQQ PNNGMVVGDQ
QQQQQQHNGS MQLQPTYYQS YVQMPPPLQL QQQQQQQQQH YSLDGIPQQP HSAPTSSFPP
PPPPPLQLNQ HQGLQQYSHA QQQQQQQHQQ QQPYHQEYPN N
