WOX13_ARATH
ID WOX13_ARATH Reviewed; 268 AA.
AC O81788;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=WUSCHEL-related homeobox 13;
GN Name=WOX13; OrderedLocusNames=At4g35550; ORFNames=F8D20.60;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Landsberg erecta;
RX PubMed=14711878; DOI=10.1242/dev.00963;
RA Haecker A., Gross-Hardt R., Geiges B., Sarkar A., Breuninger H.,
RA Herrmann M., Laux T.;
RT "Expression dynamics of WOX genes mark cell fate decisions during early
RT embryonic patterning in Arabidopsis thaliana.";
RL Development 131:657-668(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=18950478; DOI=10.1186/1471-2148-8-291;
RA Deveaux Y., Toffano-Nioche C., Claisse G., Thareau V., Morin H., Laufs P.,
RA Moreau H., Kreis M., Lecharny A.;
RT "Genes of the most conserved WOX clade in plants affect root and flower
RT development in Arabidopsis.";
RL BMC Evol. Biol. 8:291-291(2008).
RN [6]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=22946675; DOI=10.1111/tpj.12010;
RA Romera-Branchat M., Ripoll J.J., Yanofsky M.F., Pelaz S.;
RT "The WOX13 homeobox gene promotes replum formation in the Arabidopsis
RT thaliana fruit.";
RL Plant J. 73:37-49(2013).
RN [7]
RP FUNCTION, AND INDUCTION BY WOUNDING.
RX PubMed=34730809; DOI=10.1093/plphys/kiab510;
RA Ikeuchi M., Iwase A., Ito T., Tanaka H., Favero D.S., Kawamura A.,
RA Sakamoto S., Wakazaki M., Tameshige T., Fujii H., Hashimoto N., Suzuki T.,
RA Hotta K., Toyooka K., Mitsuda N., Sugimoto K.;
RT "Wound-inducible WUSCHEL-RELATED HOMEOBOX 13 is required for callus growth
RT and organ reconnection.";
RL Plant Physiol. 188:425-441(2022).
CC -!- FUNCTION: Transcription factor involved in the regulation of fruit
CC patterning (PubMed:22946675). Promotes replum development by down-
CC regulating JAG and YAB1/FIL genes activity in medial tissues
CC (PubMed:22946675). Seems to inhibit fruit dehiscence, maybe by
CC controlling valve margin lignification (PubMed:22946675). Promotes
CC callus formation at wound sites (PubMed:34730809). Is required for the
CC formation of highly vacuolated large cells in callus and for the
CC establishment of organ reconnection (PubMed:34730809). Targets directly
CC genes involved in stress-induced cellular reprogramming, and cell wall
CC modifier genes (PubMed:34730809). {ECO:0000269|PubMed:22946675,
CC ECO:0000269|PubMed:34730809}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Expressed in lateral roots, cotyledon and root
CC vasculatures, pericycle, stem cells of the primary root meristem, leaf
CC primordia, flower vasculature, stigma and gynoecium (PubMed:18950478,
CC PubMed:22946675). Expressed in developing carpels, floral buds and
CC inflorescences (PubMed:22946675). {ECO:0000269|PubMed:18950478,
CC ECO:0000269|PubMed:22946675}.
CC -!- INDUCTION: Induced by wounding. {ECO:0000269|PubMed:34730809}.
CC -!- DISRUPTION PHENOTYPE: Early flowering (PubMed:18950478). Altered fruit
CC development (PubMed:22946675). Siliques with narrow replum
CC (PubMed:22946675). Reduced number of lateral roots (PubMed:22946675).
CC {ECO:0000269|PubMed:18950478, ECO:0000269|PubMed:22946675}.
CC -!- SIMILARITY: Belongs to the WUS homeobox family. {ECO:0000305}.
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DR EMBL; AY251404; AAP37142.1; -; mRNA.
DR EMBL; AL031135; CAA20025.1; -; Genomic_DNA.
DR EMBL; AL161587; CAB80271.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE86529.1; -; Genomic_DNA.
DR EMBL; AY048268; AAK82530.1; -; mRNA.
DR EMBL; BT000538; AAN18107.1; -; mRNA.
DR PIR; T04660; T04660.
DR RefSeq; NP_195280.1; NM_119720.4.
DR AlphaFoldDB; O81788; -.
DR SMR; O81788; -.
DR BioGRID; 14989; 154.
DR IntAct; O81788; 153.
DR STRING; 3702.AT4G35550.1; -.
DR PaxDb; O81788; -.
DR PRIDE; O81788; -.
DR ProteomicsDB; 242691; -.
DR EnsemblPlants; AT4G35550.1; AT4G35550.1; AT4G35550.
DR GeneID; 829707; -.
DR Gramene; AT4G35550.1; AT4G35550.1; AT4G35550.
DR KEGG; ath:AT4G35550; -.
DR Araport; AT4G35550; -.
DR TAIR; locus:2127968; AT4G35550.
DR eggNOG; ENOG502QVBF; Eukaryota.
DR HOGENOM; CLU_071934_0_1_1; -.
DR InParanoid; O81788; -.
DR OMA; VMTDEQY; -.
DR OrthoDB; 1052636at2759; -.
DR PhylomeDB; O81788; -.
DR PRO; PR:O81788; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O81788; baseline and differential.
DR Genevisible; O81788; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR044559; WOX13-like.
DR PANTHER; PTHR46777; PTHR46777; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..268
FT /note="WUSCHEL-related homeobox 13"
FT /id="PRO_0000049380"
FT DNA_BIND 95..159
FT /note="Homeobox; WUS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 268 AA; 29673 MW; D57FCC13AB1A93DA CRC64;
MMEWDNQLQP NNHHSSNLQG IDVNGGSGAG GGMYVKVMTD EQYETLRKQI AIYGTICERL
VEMHKTLTAQ QDLAGGRMGG LYADPMMSSL GHKMTARQRW TPTPVQLQIL ERIFDQGTGT
PSKQKIKDIT EELSQHGQIA EQNVYNWFQN RRARSKRKQH GGGSSGNNNG ESEVETEVEA
LNEKRVVRPE SLLGLPDGNS NNNGLGTTTA TTTAPRPEDL CFQSPEISSD LHLLDVLSNP
RDEHLVGKMG LAESYNLYDH VEDYGMSG
