WOX14_ARATH
ID WOX14_ARATH Reviewed; 211 AA.
AC Q9LM84;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=WUSCHEL-related homeobox 14;
DE AltName: Full=Homeodomain protein PALE-2;
DE Short=AtPALE2;
GN Name=WOX14; Synonyms=PALE2; OrderedLocusNames=At1g20700; ORFNames=F2D10.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Sessa G., Carabelli M., Ciarbelli A.R., Ruzza V., Steindler C., Ruberti I.;
RT "Nucleotide sequence of the AtPALE2.";
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP IDENTIFICATION.
RX PubMed=14711878; DOI=10.1242/dev.00963;
RA Haecker A., Gross-Hardt R., Geiges B., Sarkar A., Breuninger H.,
RA Herrmann M., Laux T.;
RT "Expression dynamics of WOX genes mark cell fate decisions during early
RT embryonic patterning in Arabidopsis thaliana.";
RL Development 131:657-668(2004).
RN [5]
RP TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=18950478; DOI=10.1186/1471-2148-8-291;
RA Deveaux Y., Toffano-Nioche C., Claisse G., Thareau V., Morin H., Laufs P.,
RA Moreau H., Kreis M., Lecharny A.;
RT "Genes of the most conserved WOX clade in plants affect root and flower
RT development in Arabidopsis.";
RL BMC Evol. Biol. 8:291-291(2008).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=23578929; DOI=10.1242/dev.091314;
RA Etchells J.P., Provost C.M., Mishra L., Turner S.R.;
RT "WOX4 and WOX14 act downstream of the PXY receptor kinase to regulate plant
RT vascular proliferation independently of any role in vascular
RT organisation.";
RL Development 140:2224-2234(2013).
RN [7]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=28218997; DOI=10.1111/tpj.13513;
RA Denis E., Kbiri N., Mary V., Claisse G., Conde-E-Silva N., Kreis M.,
RA Deveaux Y.;
RT "WOX14 promotes bioactive gibberellin synthesis and vascular cell
RT differentiation in Arabidopsis.";
RL Plant J. 90:560-572(2017).
CC -!- FUNCTION: Acts redundantly with WOX4 downstream of the TDR/PXY receptor
CC kinase to regulate procambial cell proliferation and differentiation in
CC vascular tissue, independently of any role in vascular
CC (PubMed:23578929). Involved in the regulation of gibberellin (GA)
CC biosynthesis pathway (PubMed:28218997). Regulates positively the
CC expression of the GA biosynthesis gene GA3OX1, and negatively regulates
CC the expression of GA2OX1 during secondary growth, which increases
CC bioactive GA content in the inflorescence stem (PubMed:28218997).
CC Promotes vascular cell differentiation in the inflorescence stem
CC (PubMed:28218997). {ECO:0000269|PubMed:23578929,
CC ECO:0000269|PubMed:28218997}.
CC -!- FUNCTION: Transcription factor which may be involved in developmental
CC processes. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9LM84; Q8L8A5: GIF1; NbExp=3; IntAct=EBI-15193011, EBI-1396623;
CC Q9LM84; Q9MAL9: GIF2; NbExp=3; IntAct=EBI-15193011, EBI-1396863;
CC Q9LM84; Q93VH6: GIF3; NbExp=3; IntAct=EBI-15193011, EBI-15194507;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Expressed in root vasculature, pericycle and stamen
CC (PubMed:18950478). Expressed in the procambium during stem maturation
CC (PubMed:28218997). {ECO:0000269|PubMed:18950478,
CC ECO:0000269|PubMed:28218997}.
CC -!- DISRUPTION PHENOTYPE: Retarded growth of the primary root, and partial
CC sterility with aborted and short siliques (PubMed:18950478). Late
CC flowering under long-day conditions (PubMed:18950478, PubMed:28218997).
CC The double mutants wox4 and wox14 exhibit reductions in vascular cell
CC division (PubMed:23578929). {ECO:0000269|PubMed:18950478,
CC ECO:0000269|PubMed:23578929, ECO:0000269|PubMed:28218997}.
CC -!- MISCELLANEOUS: Overexpression of WOX14 increases bioactive gibberellin
CC (GA) production and induces radial growth with strong lignification of
CC vascular stem tissues. {ECO:0000269|PubMed:28218997}.
CC -!- SIMILARITY: Belongs to the WUS homeobox family. {ECO:0000305}.
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DR EMBL; AJ441297; CAD29665.1; -; mRNA.
DR EMBL; AC069251; AAF80616.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30012.1; -; Genomic_DNA.
DR RefSeq; NP_173493.2; NM_101922.3.
DR AlphaFoldDB; Q9LM84; -.
DR SMR; Q9LM84; -.
DR BioGRID; 23899; 60.
DR IntAct; Q9LM84; 59.
DR STRING; 3702.AT1G20700.1; -.
DR PaxDb; Q9LM84; -.
DR ProteomicsDB; 242548; -.
DR EnsemblPlants; AT1G20700.1; AT1G20700.1; AT1G20700.
DR GeneID; 838660; -.
DR Gramene; AT1G20700.1; AT1G20700.1; AT1G20700.
DR KEGG; ath:AT1G20700; -.
DR Araport; AT1G20700; -.
DR TAIR; locus:2030467; AT1G20700.
DR eggNOG; ENOG502QVBF; Eukaryota.
DR HOGENOM; CLU_071934_1_0_1; -.
DR InParanoid; Q9LM84; -.
DR OrthoDB; 1052636at2759; -.
DR PhylomeDB; Q9LM84; -.
DR PRO; PR:Q9LM84; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LM84; baseline and differential.
DR Genevisible; Q9LM84; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0051301; P:cell division; IMP:TAIR.
DR GO; GO:0010087; P:phloem or xylem histogenesis; IMP:TAIR.
DR GO; GO:0010072; P:primary shoot apical meristem specification; IMP:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR044559; WOX13-like.
DR PANTHER; PTHR46777; PTHR46777; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..211
FT /note="WUSCHEL-related homeobox 14"
FT /id="PRO_0000049381"
FT DNA_BIND 91..155
FT /note="Homeobox; WUS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 147..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 211 AA; 23976 MW; D8E19461EAF285D2 CRC64;
MVKKKKEKEK SKEIEEMDRE IQNGAYSGRV MTEEQMEILR KQIAVYAVIC DQLVLLHNSL
SSYHPLSSGV RPMVGGYFDP MGASSSSHRI STRHRWTPTS TQLQILESIY DEGSGTPNRR
RIREIATELS EHGQITETNV YNWFQNRRAR SKRKQPQTTT ANGQADDVAV TTEERRSCGD
SGGLESYEHI LFPSPDLGIE HLLSIGKFME T
