ID   WOX2_ARATH              Reviewed;         260 AA.
AC   Q6X7K1; Q6X7K2; Q9FIE5;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 126.
DE   RecName: Full=WUSCHEL-related homeobox 2;
GN   Name=WOX2; OrderedLocusNames=At5g59340; ORFNames=MNC17.25;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC   STRAIN=cv. Landsberg erecta;
RX   PubMed=14711878; DOI=10.1242/dev.00963;
RA   Haecker A., Gross-Hardt R., Geiges B., Sarkar A., Breuninger H.,
RA   Herrmann M., Laux T.;
RT   "Expression dynamics of WOX genes mark cell fate decisions during early
RT   embryonic patterning in Arabidopsis thaliana.";
RL   Development 131:657-668(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10048488; DOI=10.1093/dnares/5.6.379;
RA   Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence
RT   features of the regions of 1,081,958 bp covered by seventeen physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:379-391(1998).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- FUNCTION: Probable transcription factor involved in embryonic
CC       patterning. Required for apical embryo development after fertilization.
CC       Its specific localization to the apical daughter cell of the zygote,
CC       while WOX8 is confined to the basal cell, suggests that the asymmetric
CC       division of the plant zygote separates determinants of apical and basal
CC       cell fates. {ECO:0000269|PubMed:14711878}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Detected in the egg cell and the central cell of
CC       the embryo sac, but not in the synergids, the antipodals or the male
CC       gametophyte. After fertilization, it is expressed in the zygote. After
CC       the first division of the zygote, it is detected exclusively in the
CC       apical daughter cell, while WOX8 is expressed in the basal daughter
CC       cell. Subsequently, it is expressed in all cells of the 4-cell embryo
CC       proper and predominantly in the apical domain of the 8-cell embryo.
CC       However, in some 8-cell embryos it is also weakly expressed in the
CC       central domain suggesting that expression shifts to the most apical
CC       cells during this stage. Expression remains restricted to the apical
CC       domain in the 16-cell embryo and the early-globular stage. Not
CC       expressed in the apical domain thereafter. However, in heart stage
CC       embryos it is weakly expressed in a ring of epidermal cells
CC       approximately at the junction of hypocotyl and root. Not expressed in
CC       mature embryos, endosperm or postembryonically in inflorescences.
CC       {ECO:0000269|PubMed:14711878}.
CC   -!- SIMILARITY: Belongs to the WUS homeobox family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB09778.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AY251392; AAP37131.1; -; mRNA.
DR   EMBL; AY251393; AAP37132.1; -; mRNA.
DR   EMBL; AB016890; BAB09778.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED97173.1; -; Genomic_DNA.
DR   RefSeq; NP_200742.2; NM_125325.3.
DR   AlphaFoldDB; Q6X7K1; -.
DR   SMR; Q6X7K1; -.
DR   BioGRID; 21297; 1.
DR   STRING; 3702.AT5G59340.1; -.
DR   PaxDb; Q6X7K1; -.
DR   PRIDE; Q6X7K1; -.
DR   ProteomicsDB; 242641; -.
DR   EnsemblPlants; AT5G59340.1; AT5G59340.1; AT5G59340.
DR   GeneID; 836053; -.
DR   Gramene; AT5G59340.1; AT5G59340.1; AT5G59340.
DR   KEGG; ath:AT5G59340; -.
DR   Araport; AT5G59340; -.
DR   TAIR; locus:2168504; AT5G59340.
DR   eggNOG; ENOG502RZ2B; Eukaryota.
DR   HOGENOM; CLU_070454_0_0_1; -.
DR   InParanoid; Q6X7K1; -.
DR   OMA; VNSNEPK; -.
DR   OrthoDB; 1131986at2759; -.
DR   PhylomeDB; Q6X7K1; -.
DR   PRO; PR:Q6X7K1; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q6X7K1; baseline and differential.
DR   Genevisible; Q6X7K1; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0010654; P:apical cell fate commitment; IMP:TAIR.
DR   GO; GO:0090451; P:cotyledon boundary formation; IGI:TAIR.
DR   GO; GO:0048825; P:cotyledon development; IMP:TAIR.
DR   GO; GO:0009880; P:embryonic pattern specification; IMP:TAIR.
DR   GO; GO:0009942; P:longitudinal axis specification; IMP:TAIR.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IGI:TAIR.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR044555; WUSCHEL-like.
DR   PANTHER; PTHR45940; PTHR45940; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..260
FT                   /note="WUSCHEL-related homeobox 2"
FT                   /id="PRO_0000049366"
FT   DNA_BIND        10..74
FT                   /note="Homeobox; WUS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   CONFLICT        181
FT                   /note="N -> H (in Ref. 1; AAP37131)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   260 AA;  29183 MW;  0C2A1126F0A32A39 CRC64;
     MENEVNAGTA SSSRWNPTKD QITLLENLYK EGIRTPSADQ IQQITGRLRA YGHIEGKNVF
     YWFQNHKARQ RQKQKQERMA YFNRLLHKTS RFFYPPPCSN VGCVSPYYLQ QASDHHMNQH
     GSVYTNDLLH RNNVMIPSGG YEKRTVTQHQ KQLSDIRTTA ATRMPISPSS LRFDRFALRD
     NCYAGEDINV NSSGRKTLPL FPLQPLNASN ADGMGSSSFA LGSDSPVDCS SDGAGREQPF
     IDFFSGGSTS TRFDSNGNGL