WOX5_ARATH
ID WOX5_ARATH Reviewed; 182 AA.
AC Q8H1D2; Q9C775;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=WUSCHEL-related homeobox 5;
GN Name=WOX5; OrderedLocusNames=At3g11260; ORFNames=F11B9.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=14711878; DOI=10.1242/dev.00963;
RA Haecker A., Gross-Hardt R., Geiges B., Sarkar A., Breuninger H.,
RA Herrmann M., Laux T.;
RT "Expression dynamics of WOX genes mark cell fate decisions during early
RT embryonic patterning in Arabidopsis thaliana.";
RL Development 131:657-668(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Fu C., Bush D.R., Martienssen R.A.;
RT "Homeodomain transcription factor, similar to wuschel protein.";
RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=25631790; DOI=10.1038/ncomms7003;
RA Zhang Y., Jiao Y., Liu Z., Zhu Y.-X.;
RT "ROW1 maintains quiescent centre identity by confining WOX5 expression to
RT specific cells.";
RL Nat. Commun. 6:6003-6003(2015).
CC -!- FUNCTION: Transcription factor, which may be involved in the
CC specification and maintenance of the stem cells (QC cells) in the root
CC apical meristem (RAM). {ECO:0000269|PubMed:25631790}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in the central cells of a
CC quiescent center (QC) of the root. {ECO:0000269|PubMed:14711878}.
CC -!- DEVELOPMENTAL STAGE: Specifically expressed in the hypophysis of the
CC majority of early globular embryos, approximately one round of cell
CC division after the 16-cell stage, but never at the 16-cell stage
CC itself. After the division of the hypophysis, it is detected in the
CC upper lens-shaped cell that gives rise to the QC, but not in the lower
CC daughter cell that gives rise to the central root cap. Subsequently, in
CC heart stage and bent cotyledon stage embryos, it is detected in the
CC four cells of the QC, which are the direct descendants of the lens-
CC shaped cell. Also expressed in patches of cells that appeared
CC associated with the vascular primordium of the cotyledons. This
CC expression is strongest in late heart stage embryos and then gradually
CC decreases. {ECO:0000269|PubMed:14711878}.
CC -!- DISRUPTION PHENOTYPE: Abnormal quiescent center (QC) in the root apical
CC meristem (RAM) and defects in cell differentiation.
CC {ECO:0000269|PubMed:25631790}.
CC -!- SIMILARITY: Belongs to the WUS homeobox family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG50976.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY251398; AAP37136.1; -; mRNA.
DR EMBL; AY150812; AAN64659.1; -; mRNA.
DR EMBL; AC073395; AAG50976.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE75021.1; -; Genomic_DNA.
DR RefSeq; NP_187735.2; NM_111961.4.
DR AlphaFoldDB; Q8H1D2; -.
DR SMR; Q8H1D2; -.
DR BioGRID; 5631; 32.
DR IntAct; Q8H1D2; 4.
DR STRING; 3702.AT3G11260.1; -.
DR iPTMnet; Q8H1D2; -.
DR PaxDb; Q8H1D2; -.
DR PRIDE; Q8H1D2; -.
DR ProteomicsDB; 242644; -.
DR EnsemblPlants; AT3G11260.1; AT3G11260.1; AT3G11260.
DR GeneID; 820297; -.
DR Gramene; AT3G11260.1; AT3G11260.1; AT3G11260.
DR KEGG; ath:AT3G11260; -.
DR Araport; AT3G11260; -.
DR TAIR; locus:2074638; AT3G11260.
DR eggNOG; ENOG502RYVY; Eukaryota.
DR HOGENOM; CLU_070454_2_0_1; -.
DR InParanoid; Q8H1D2; -.
DR OMA; FSPYSSC; -.
DR OrthoDB; 1304054at2759; -.
DR PhylomeDB; Q8H1D2; -.
DR PRO; PR:Q8H1D2; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8H1D2; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0043565; F:sequence-specific DNA binding; IPI:TAIR.
DR GO; GO:0010078; P:maintenance of root meristem identity; IMP:UniProtKB.
DR GO; GO:1902459; P:positive regulation of stem cell population maintenance; IMP:TAIR.
DR GO; GO:0009733; P:response to auxin; IEP:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR044555; WUSCHEL-like.
DR PANTHER; PTHR45940; PTHR45940; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..182
FT /note="WUSCHEL-related homeobox 5"
FT /id="PRO_0000049371"
FT DNA_BIND 20..84
FT /note="Homeobox; WUS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 182 AA; 21226 MW; 70502169709BB91D CRC64;
MSFSVKGRSL RGNNNGGTGT KCGRWNPTVE QLKILTDLFR AGLRTPTTDQ IQKISTELSF
YGKIESKNVF YWFQNHKARE RQKRRKISID FDHHHHQPST RDVFEISEED CQEEEKVIET
LQLFPVNSFE DSNSKVDKMR ARGNNQYREY IRETTTTSFS PYSSCGAEME HPPPLDLRLS
FL
