WOX6_ARATH
ID WOX6_ARATH Reviewed; 271 AA.
AC Q9ZVF5;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=WUSCHEL-related homeobox 6;
DE AltName: Full=Protein PRETTY FEW SEEDS 2;
GN Name=WOX6; Synonyms=PFS2; OrderedLocusNames=At2g01500; ORFNames=F2I9.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Landsberg erecta;
RX PubMed=14711878; DOI=10.1242/dev.00963;
RA Haecker A., Gross-Hardt R., Geiges B., Sarkar A., Breuninger H.,
RA Herrmann M., Laux T.;
RT "Expression dynamics of WOX genes mark cell fate decisions during early
RT embryonic patterning in Arabidopsis thaliana.";
RL Development 131:657-668(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=15659481; DOI=10.1242/dev.01654;
RA Park S.O., Zheng Z., Oppenheimer D.G., Hauser B.A.;
RT "The PRETTY FEW SEEDS2 gene encodes an Arabidopsis homeodomain protein that
RT regulates ovule development.";
RL Development 132:841-849(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor that plays a central role in ovule
CC patterning by regulating cell proliferation of the maternal integuments
CC and differentiation of the maegaspore mother cell (MCC). Involved in
CC AGAMOUS (AG) repression in leaves. {ECO:0000269|PubMed:15659481}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Highly expressed in developing ovules. Present in
CC developing primordia and differentiating organs but absent in mature
CC organs. {ECO:0000269|PubMed:15659481}.
CC -!- DEVELOPMENTAL STAGE: In developing seeds, it is expressed in the
CC embryo, suspensor and endosperm nuclei, but absent in the integuments.
CC In seedlings, it is expressed in the shoot apical meristem and leaf
CC primordia, but not in expanded cotyledons or mature leaves. In
CC reproductive structures, transcripts could be detected in floral apical
CC meristems, floral primordia, stamens and pistils. Also expressed in the
CC tapetum in anthers and in the gynoecium. Weakly expressed in petals,
CC sepals and the walls of carpels. {ECO:0000269|PubMed:15659481}.
CC -!- SIMILARITY: Belongs to the WUS homeobox family. {ECO:0000305}.
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DR EMBL; AY251399; AAP37137.2; -; mRNA.
DR EMBL; AY885222; AAW78002.1; -; mRNA.
DR EMBL; AC005560; AAC67326.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC05461.1; -; Genomic_DNA.
DR EMBL; AY085832; AAM63047.1; -; mRNA.
DR PIR; E84425; E84425.
DR RefSeq; NP_565263.1; NM_126211.2.
DR AlphaFoldDB; Q9ZVF5; -.
DR SMR; Q9ZVF5; -.
DR STRING; 3702.AT2G01500.1; -.
DR iPTMnet; Q9ZVF5; -.
DR PaxDb; Q9ZVF5; -.
DR PRIDE; Q9ZVF5; -.
DR EnsemblPlants; AT2G01500.1; AT2G01500.1; AT2G01500.
DR GeneID; 814678; -.
DR Gramene; AT2G01500.1; AT2G01500.1; AT2G01500.
DR KEGG; ath:AT2G01500; -.
DR Araport; AT2G01500; -.
DR TAIR; locus:2049547; AT2G01500.
DR eggNOG; ENOG502QVAV; Eukaryota.
DR HOGENOM; CLU_1020653_0_0_1; -.
DR InParanoid; Q9ZVF5; -.
DR OMA; INNEDHC; -.
DR OrthoDB; 1219587at2759; -.
DR PhylomeDB; Q9ZVF5; -.
DR PRO; PR:Q9ZVF5; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZVF5; baseline and differential.
DR Genevisible; Q9ZVF5; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0048353; C:primary endosperm nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IMP:TAIR.
DR GO; GO:0048314; P:embryo sac morphogenesis; IMP:TAIR.
DR GO; GO:0048437; P:floral organ development; IMP:TAIR.
DR GO; GO:0048366; P:leaf development; IMP:TAIR.
DR GO; GO:0009965; P:leaf morphogenesis; IMP:TAIR.
DR GO; GO:0048446; P:petal morphogenesis; IMP:TAIR.
DR GO; GO:0048482; P:plant ovule morphogenesis; IMP:TAIR.
DR GO; GO:0051510; P:regulation of unidimensional cell growth; IMP:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR044555; WUSCHEL-like.
DR PANTHER; PTHR45940; PTHR45940; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Homeobox; Nucleus;
KW Oogenesis; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..271
FT /note="WUSCHEL-related homeobox 6"
FT /id="PRO_0000049373"
FT DNA_BIND 57..121
FT /note="Homeobox; WUS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 118..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 271 AA; 31453 MW; 1B1B8ADD752E72BD CRC64;
MGYISNNNLI NYLPLSTTQP PLLLTHCDIN GNDHHQLITA SSGEHDIDER KNNIPAAATL
RWNPTPEQIT TLEELYRSGT RTPTTEQIQQ IASKLRKYGR IEGKNVFYWF QNHKARERLK
RRRREGGAII KPHKDVKDSS SGGHRVDQTK LCPSFPHTNR PQPQHELDPA SYNKDNNANN
EDHGTTEESD QRASEVGKYA TWRNLVTWSI TQQPEEINID ENVNGEEEET RDNRTLNLFP
VREYQEKTGR LIEKTKACNY CYYYEFMPLK N
