WR52R_ARATH
ID WR52R_ARATH Reviewed; 1373 AA.
AC C4B7M6;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Disease resistance protein RRS1 {ECO:0000303|PubMed:19519800};
DE AltName: Full=Disease resistance protein RCH2 {ECO:0000303|PubMed:19519800};
DE AltName: Full=Probable WRKY transcription factor 52;
DE AltName: Full=Resistance to Colletotrichum higginsianum 2 protein {ECO:0000303|PubMed:19519800};
DE AltName: Full=Resistance to Ralstonia solanacearum 1 protein {ECO:0000303|PubMed:19519800};
GN Name=RRS1 {ECO:0000303|PubMed:19519800}; Synonyms=RCH2, WRKY52;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:BAH59425.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=cv. RLD;
RX PubMed=19519800; DOI=10.1111/j.1365-313x.2009.03949.x;
RA Narusaka M., Shirasu K., Noutoshi Y., Kubo Y., Shiraishi T., Iwabuchi M.,
RA Narusaka Y.;
RT "RRS1 and RPS4 provide a dual Resistance-gene system against fungal and
RT bacterial pathogens.";
RL Plant J. 60:218-226(2009).
CC -!- FUNCTION: Transcription factor. Interacts specifically with the W box
CC (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-
CC acting element. Acts also as a disease resistance protein involved in
CC resistance to fungal and bacterial pathogens, including R.solanacearum,
CC P.syringae pv. tomato and C.higginsianum.
CC {ECO:0000250|UniProtKB:P0DKH5, ECO:0000269|PubMed:19519800,
CC ECO:0000305}.
CC -!- SUBUNIT: Interacts with PopP2, a R.solanacearum type III effector.
CC {ECO:0000250|UniProtKB:P0DKH5}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00223}.
CC -!- MISCELLANEOUS: Ecotypes susceptible to C.higginsianum or
CC R.solanacearum, such as cv. Columbia, contain a protein with a
CC premature stop codon while the longer allele found in cv. Nd-1, cv.
CC Wassilewskija or cv. RLD confers resistance.
CC {ECO:0000269|PubMed:19519800}.
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DR EMBL; AB470472; BAH59425.1; -; mRNA.
DR AlphaFoldDB; C4B7M6; -.
DR SMR; C4B7M6; -.
DR ExpressionAtlas; C4B7M6; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 2.20.25.80; -; 1.
DR Gene3D; 3.40.50.10140; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR003657; WRKY_dom.
DR InterPro; IPR036576; WRKY_dom_sf.
DR PANTHER; PTHR11017; PTHR11017; 2.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF03106; WRKY; 1.
DR SMART; SM00774; WRKY; 1.
DR SUPFAM; SSF118290; SSF118290; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52200; SSF52200; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50104; TIR; 1.
DR PROSITE; PS50811; WRKY; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; DNA-binding; Leucine-rich repeat; Nucleotide-binding; Nucleus;
KW Plant defense; Repeat; Transcription; Transcription regulation.
FT CHAIN 1..1373
FT /note="Disease resistance protein RRS1"
FT /id="PRO_0000431362"
FT DOMAIN 5..146
FT /note="TIR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
FT DOMAIN 170..421
FT /note="NB-ARC"
FT /evidence="ECO:0000255"
FT REPEAT 498..522
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 535..553
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 554..575
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 577..598
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 621..646
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 665..688
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 742..766
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 768..793
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 831..854
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT DNA_BIND 1204..1272
FT /note="WRKY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00223"
FT REGION 1300..1323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 988..1005
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT BINDING 179..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00499"
SQ SEQUENCE 1373 AA; 155346 MW; BDC8F1B268D9536F CRC64;
MTNCEKDEEF VCISCVEEVR YSFVSHLSEA LRRKGINNVV VDVDIDDLLF KESQAKIEKA
GVSVMVLPGN CDPSEVWLDK FAKVLECQRN NKDQAVVSVL YGDSLLRDQW LSELDFRGLS
RIHQSRKECS DSILVEEIVR DVYETHFYVG RIGIYSKLLE IENMVNKQPI GIRCVGIWGM
PGIGKTTLAK AVFDQMSSAF DASCFIEDYD KSIHEKGLYC LLEEQLLPGN DATIMKLNSL
RDRLNSKRVL VVLDDVCNAL VAESFLEGFD WLGPGSLIII TSRDKQVFRL CGINQIYEVQ
GLNEKEARQL FLLSASIKED MGEQNLHELS VRVISYANGN PLAISVYGRE LKGKKKLSEM
ETAFLKLKRR PPFKIVDAFK SSYDTLSDNE KNIFLDIACF FQGENVNYVI QLLEGCGFFP
HVEIDVLVDK CLVTISENRV WLHKLTQDIG REIINGETVQ IERRRRLWEP WSIKYLLEYN
EHKANGEPKT TFKRAQGSEE IEGLFLDTSN LRFDLQPSAF KNMLNLRLLK IYCSNPEVHP
VINFPTGSLH SLPNELRLLH WENYPLKSLP QNFDPRHLVE INMPYSQLQK LWGGTKNLEM
LRTIRLCHSQ HLVDIDDLLK AENLEVIDLQ GCTRLQNFPA AGRLLRLRVV NLSGCIKIKS
VLEIPPNIEK LHLQGTGILA LPVSTVKPNH RELVNFLTEI PGLSEASKLE RLTSLLESNS
SCQDLGKLIC LELKDCSCLQ SLPNMANLDL NVLDLSGCSS LNSIQGFPRF LKQLYLGGTA
IREVPQLPQS LEILNAHGSC LRSLPNMANL EFLKVLDLSG CSELETIQGF PRNLKELYFA
GTTLREVPQL PLSLEVLNAH GSDSEKLPMH YKFNNFFDLS QQVVNDFFLK ALTYVKHIPR
GYTQELINKA PTFSFSAPSH TNQNATFDLQ PGSSVMTRLN HSWRNTLVGF GMLVEVAFPE
DYCDATDVGI SCVCRWSNKE GRSCRIERNF HCWAPGKVVP KVRKDHTFVF SDVNMRPSTG
EGNDPDIWAG LVVFEFFPIN QQTKCLNDRF TVTRCGVRVI NVATGNTSLE NISLVLSLDP
VEVSGYEVLR VSYDDLQEMD KVLFLYIASL FNDEDVDFVA PLIAGIDLDV SSGLKVLADV
SLISVSSNGE IVMHSLQRQM GKEILHGQSM LLSDCESSMT ENLSDVPKKE KKHRESKVKK
VVSIPAIDEG DLWTWRKYGQ KDILGSRFPR GYYRCAYKFT HGCKATKQVQ RSETDSNMLA
ITYLSEHNHP RPTKRKALAD STRSTSSSIC SAITTSASSR VFQNKDEPNK PHLPSSSTPP
GNAAVLFKMT DMEEFQDNME VDNDVVDTRT LALFPEFQHQ PEEEYPWSTF FDD
