ID   WRT3_CAEEL              Reviewed;         179 AA.
AC   Q20170; Q9XZF4;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 3.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Warthog protein 3;
DE   Flags: Precursor;
GN   Name=wrt-3; ORFNames=F38E11.7;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-135, NOMENCLATURE, AND TISSUE SPECIFICITY.
RX   PubMed=10523520; DOI=10.1101/gr.9.10.909;
RA   Aspoeck G., Kagoshima H., Niklaus G., Buerglin T.R.;
RT   "Caenorhabditis elegans has scores of hedgehog-related genes: sequence and
RT   expression analysis.";
RL   Genome Res. 9:909-923(1999).
CC   -!- FUNCTION: Intercellular signal essential for a variety of patterning
CC       events during development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in the trinucleate pharyngeal gland cell
CC       g1, seam cells and hypodermis. {ECO:0000269|PubMed:10523520}.
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DR   EMBL; Z68342; CAA92775.2; -; Genomic_DNA.
DR   EMBL; AF139522; AAD33832.1; -; mRNA.
DR   PIR; T21969; T21969.
DR   RefSeq; NP_501673.2; NM_069272.3.
DR   AlphaFoldDB; Q20170; -.
DR   STRING; 6239.F38E11.7a; -.
DR   PaxDb; Q20170; -.
DR   PRIDE; Q20170; -.
DR   EnsemblMetazoa; F38E11.7a.1; F38E11.7a.1; WBGene00006949.
DR   UCSC; F38E11.7; c. elegans.
DR   WormBase; F38E11.7a; CE34013; WBGene00006949; wrt-3.
DR   eggNOG; KOG3638; Eukaryota.
DR   GeneTree; ENSGT00970000196402; -.
DR   InParanoid; Q20170; -.
DR   OMA; TMCCEFE; -.
DR   OrthoDB; 1513122at2759; -.
DR   PhylomeDB; Q20170; -.
DR   PRO; PR:Q20170; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00006949; Expressed in larva and 3 other tissues.
DR   ExpressionAtlas; Q20170; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031131; Warthog_3/5.
DR   PANTHER; PTHR46706:SF2; PTHR46706:SF2; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..179
FT                   /note="Warthog protein 3"
FT                   /id="PRO_0000268641"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        147
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   179 AA;  20966 MW;  F9FA6891A2BF2BDD CRC64;
     MLYHVEMFTI ILLFGFSLAD YCGSDQVPYG MEVHHSGVVR LMCSKPNCYD KNYSDCPERA
     ESRHGCQKSN QWVGGFEKNI EGDLYTMCCE FEGLEKYAKV RYSDVRIRRG EFFEGEEKEN
     DDGDVVKFDV IKDIRMHKDD EGQAYYNLTV LSFNCESIPD VKPAWYQKSQ WPYFQFAKN