ID   WRT5_CAEEL              Reviewed;         176 AA.
AC   Q9U7D3; O02116; Q1RS88;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 2.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Warthog protein 5;
DE   Flags: Precursor;
GN   Name=wrt-5; ORFNames=W03D2.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), NOMENCLATURE, TISSUE SPECIFICITY,
RP   AND DEVELOPMENTAL STAGE.
RX   PubMed=10523520; DOI=10.1101/gr.9.10.909;
RA   Aspoeck G., Kagoshima H., Niklaus G., Buerglin T.R.;
RT   "Caenorhabditis elegans has scores of hedgehog-related genes: sequence and
RT   expression analysis.";
RL   Genome Res. 9:909-923(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION,
RP   AND DISRUPTION PHENOTYPE.
RX   PubMed=16413526; DOI=10.1016/j.ydbio.2005.11.028;
RA   Hao L., Aspoeck G., Buerglin T.R.;
RT   "The hedgehog-related gene wrt-5 is essential for hypodermal development in
RT   Caenorhabditis elegans.";
RL   Dev. Biol. 290:323-336(2006).
CC   -!- FUNCTION: Intercellular signal essential for a variety of patterning
CC       events during development. {ECO:0000269|PubMed:16413526}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16413526}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=Q9U7D3-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=Q9U7D3-2; Sequence=VSP_021976, VSP_021977;
CC   -!- TISSUE SPECIFICITY: Expressed in seam cells, excretory cell,
CC       reproductive system, pharynx, pharyngeal-intestinal valve cells,
CC       neurons and neuronal support cells. {ECO:0000269|PubMed:10523520,
CC       ECO:0000269|PubMed:16413526}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the seam cells of 1.2-fold embryos.
CC       {ECO:0000269|PubMed:10523520, ECO:0000269|PubMed:16413526}.
CC   -!- DISRUPTION PHENOTYPE: Worms either die at embryonic or larval stages
CC       (43%), or exhibit variable abnormal morphology.
CC       {ECO:0000269|PubMed:16413526}.
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DR   EMBL; AF139520; AAD33830.1; -; mRNA.
DR   EMBL; FO080786; CCD66761.1; -; Genomic_DNA.
DR   EMBL; FO080786; CCD66762.1; -; Genomic_DNA.
DR   PIR; T28762; T28762.
DR   RefSeq; NP_001040994.1; NM_001047529.2. [Q9U7D3-1]
DR   RefSeq; NP_001040995.1; NM_001047530.2. [Q9U7D3-2]
DR   AlphaFoldDB; Q9U7D3; -.
DR   BioGRID; 42298; 1.
DR   DIP; DIP-24286N; -.
DR   IntAct; Q9U7D3; 1.
DR   STRING; 6239.W03D2.5a; -.
DR   PaxDb; Q9U7D3; -.
DR   PeptideAtlas; Q9U7D3; -.
DR   EnsemblMetazoa; W03D2.5a.1; W03D2.5a.1; WBGene00006951. [Q9U7D3-1]
DR   EnsemblMetazoa; W03D2.5b.1; W03D2.5b.1; WBGene00006951. [Q9U7D3-2]
DR   GeneID; 177162; -.
DR   KEGG; cel:CELE_W03D2.5; -.
DR   UCSC; W03D2.5b; c. elegans. [Q9U7D3-1]
DR   CTD; 177162; -.
DR   WormBase; W03D2.5a; CE14514; WBGene00006951; wrt-5. [Q9U7D3-1]
DR   WormBase; W03D2.5b; CE33717; WBGene00006951; wrt-5. [Q9U7D3-2]
DR   eggNOG; KOG3638; Eukaryota.
DR   HOGENOM; CLU_130582_0_0_1; -.
DR   InParanoid; Q9U7D3; -.
DR   OMA; PFGIEVH; -.
DR   OrthoDB; 1513122at2759; -.
DR   PhylomeDB; Q9U7D3; -.
DR   PRO; PR:Q9U7D3; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00006951; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   ExpressionAtlas; Q9U7D3; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; ISS:WormBase.
DR   GO; GO:0005102; F:signaling receptor binding; ISS:WormBase.
DR   GO; GO:0007154; P:cell communication; ISS:WormBase.
DR   InterPro; IPR031131; Warthog_3/5.
DR   PANTHER; PTHR46706:SF2; PTHR46706:SF2; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Developmental protein; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..176
FT                   /note="Warthog protein 5"
FT                   /id="PRO_0000268642"
FT   CARBOHYD        70
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..87
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_021976"
FT   VAR_SEQ         105
FT                   /note="K -> KVGIFGGKFEKIGGIFHENPNFQ (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_021977"
FT   CONFLICT        118
FT                   /note="E -> K (in Ref. 1; AAD33830)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   176 AA;  20134 MW;  08AE43250576D7C3 CRC64;
     MCSMWLMASW LMAFVAGSTL ADYCGDHKVP FGMEVHKNGN VNILCSRPSC HEKKYAECPE
     RATSTTCSTN SSWVGGVTQH SDGSLRLMCC EYDLLPTYST IQYEKLTIRT GEYFEGDEQM
     EGDVVTAFDL IGNIEQVKEP DGKYSYNLLI YRYHCGNIPD TPPAWYMKKQ WPYWEK