ID   WSB1_DANRE              Reviewed;         423 AA.
AC   Q7T2F6;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=WD repeat and SOCS box-containing protein 1;
DE            Short=WSB-1;
GN   Name=wsb1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable substrate-recognition component of a SCF-like ECS
CC       (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC       which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Component of a probable ECS E3 ubiquitin-protein ligase
CC       complex that contains the Elongin BC complex. {ECO:0000250}.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin ligase
CC       complexes. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC054567; AAH54567.1; -; mRNA.
DR   RefSeq; NP_955927.1; NM_199633.1.
DR   AlphaFoldDB; Q7T2F6; -.
DR   SMR; Q7T2F6; -.
DR   STRING; 7955.ENSDARP00000005989; -.
DR   PaxDb; Q7T2F6; -.
DR   PRIDE; Q7T2F6; -.
DR   Ensembl; ENSDART00000008854; ENSDARP00000005989; ENSDARG00000021343.
DR   GeneID; 323226; -.
DR   KEGG; dre:323226; -.
DR   CTD; 26118; -.
DR   ZFIN; ZDB-GENE-030131-1946; wsb1.
DR   eggNOG; KOG0266; Eukaryota.
DR   GeneTree; ENSGT00890000139406; -.
DR   HOGENOM; CLU_056876_0_0_1; -.
DR   InParanoid; Q7T2F6; -.
DR   OMA; YVWDPHT; -.
DR   OrthoDB; 805365at2759; -.
DR   PhylomeDB; Q7T2F6; -.
DR   TreeFam; TF329216; -.
DR   Reactome; R-DRE-8951664; Neddylation.
DR   Reactome; R-DRE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q7T2F6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 15.
DR   Bgee; ENSDARG00000021343; Expressed in pharyngeal gill and 27 other tissues.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR011045; N2O_reductase_N.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF07525; SOCS_box; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF158235; SSF158235; 1.
DR   SUPFAM; SSF50974; SSF50974; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50225; SOCS; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..423
FT                   /note="WD repeat and SOCS box-containing protein 1"
FT                   /id="PRO_0000347227"
FT   REPEAT          125..166
FT                   /note="WD 1"
FT   REPEAT          169..209
FT                   /note="WD 2"
FT   REPEAT          213..252
FT                   /note="WD 3"
FT   REPEAT          255..294
FT                   /note="WD 4"
FT   REPEAT          310..347
FT                   /note="WD 5"
FT   DOMAIN          373..423
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT   REGION          76..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   423 AA;  47086 MW;  2E83C845634562E1 CRC64;
     MASFPDCVNE NEIGKAKFIG ELIPPVAPFD QKSGRETWTV AFAPDGSYFA WSQGHRIVRL
     VPWKKCLASF SVRKEDRSSG AGPRRLSRQN SEGSLLPGEP REHTIDCGDI VWGLAFGSSV
     PEKQSRCVNI EWHRFKFGQD QLLLATGLNN GRIKIWDVYT GKLLLNLMDH TDIVRDLTFA
     PDGSLVLVSA SRDKTLRVWD LKDDGNMVKV LRGHQNWVYC SAFSPDSSVL CSVGAGKAVF
     LWDMDKYTLI RKLEGHHNDV VCCEFSPDGA LLATASYDTR VIVWDPHTAT VLLELGHLFP
     PPSPIFAGGA NDRWVRSVAF CHDGRHIASV TDDRLVRFWS IDEKSPQAIG PLTNGLCCAF
     STDGSVLSAG SRDGSVHFWA SPRSIASLQH LCRMTLRRVM PTQQVYTLPI PFSMQDYLAY
     KTL