ID   WSB1_TAKRU              Reviewed;         427 AA.
AC   Q9W5Z5;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=WD repeat and SOCS box-containing protein 1;
DE            Short=WSB-1;
GN   Name=wsb1;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=10415327; DOI=10.1016/s0378-1119(99)00222-x;
RA   Kehrer-Sawatzki H., Maier C., Moschgath E., Elgar G., Krone W.;
RT   "Characterization of three genes, AKAP84, BAW and WSB1, located 3' to the
RT   neurofibromatosis type 1 locus in Fugu rubripes.";
RL   Gene 235:1-11(1999).
CC   -!- FUNCTION: Probable substrate-recognition component of a SCF-like ECS
CC       (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC       which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Component of a probable ECS E3 ubiquitin-protein ligase
CC       complex that contains the Elongin BC complex. {ECO:0000250}.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin ligase
CC       complexes. {ECO:0000250}.
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DR   EMBL; AF157597; AAD39552.1; -; mRNA.
DR   EMBL; AF064564; AAD32247.1; -; Genomic_DNA.
DR   RefSeq; NP_001027919.1; NM_001032747.1.
DR   AlphaFoldDB; Q9W5Z5; -.
DR   SMR; Q9W5Z5; -.
DR   STRING; 31033.ENSTRUP00000011664; -.
DR   GeneID; 445931; -.
DR   KEGG; tru:445931; -.
DR   CTD; 26118; -.
DR   eggNOG; KOG0266; Eukaryota.
DR   InParanoid; Q9W5Z5; -.
DR   OrthoDB; 805365at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF07525; SOCS_box; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF158235; SSF158235; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50225; SOCS; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..427
FT                   /note="WD repeat and SOCS box-containing protein 1"
FT                   /id="PRO_0000051459"
FT   REPEAT          129..170
FT                   /note="WD 1"
FT   REPEAT          173..213
FT                   /note="WD 2"
FT   REPEAT          217..256
FT                   /note="WD 3"
FT   REPEAT          259..298
FT                   /note="WD 4"
FT   REPEAT          314..353
FT                   /note="WD 5"
FT   DOMAIN          379..427
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
SQ   SEQUENCE   427 AA;  47102 MW;  75C95FC8A8D4302F CRC64;
     MASFPESVNE NDIDKAKFIG ELLVPMAPFD QKAGREAWTV AFAPDGSYFA WSQGHRIVRL
     IPWAKCLSSF SVRHGGEVTN PTSPRHLSRQ SCKGGSVIPM AGAPPEHTID CGGIVWGMAF
     GSSVPEKQSR SINIEWHHFQ FGRDQLLLAT GLNNGRIKIW DVYTGTLLLN LMDHTDIVRD
     LTFAPDGSLM LVSASTDKKL RVWDLKDDGN MVKVLWGHPN RVYSSAFSPD SSVLCSVGAS
     KAVLLWNMDK YTLIRKLEGH HNDVVSCEFS PDGALLATAS YDTRVIVWDH QRGSILLELG
     HLFPPPSPIF AGGANDRWVR SVSFCADGRH IASVSDDRLV RFWSIEERAP QAVASLPNGL
     CCAFSTTGSV LAAGTCDGSV HFWECPRSIA SLQHLCRMAL RRVKTTQQVE ALPVPMPLRD
     FLTYRVV