ID   WSB1_XENTR              Reviewed;         422 AA.
AC   Q6P1V3;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=WD repeat and SOCS box-containing protein 1;
DE            Short=WSB-1;
GN   Name=wsb1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable substrate-recognition component of a SCF-like ECS
CC       (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC       which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Component of a probable ECS E3 ubiquitin-protein ligase
CC       complex that contains the Elongin BC complex. {ECO:0000250}.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin ligase
CC       complexes. {ECO:0000250}.
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DR   EMBL; BC064858; AAH64858.1; -; mRNA.
DR   RefSeq; NP_989387.1; NM_204056.1.
DR   AlphaFoldDB; Q6P1V3; -.
DR   SMR; Q6P1V3; -.
DR   STRING; 8364.ENSXETP00000046179; -.
DR   PaxDb; Q6P1V3; -.
DR   DNASU; 395021; -.
DR   Ensembl; ENSXETT00000046179; ENSXETP00000046179; ENSXETG00000021353.
DR   GeneID; 395021; -.
DR   KEGG; xtr:395021; -.
DR   CTD; 26118; -.
DR   Xenbase; XB-GENE-5920309; wsb1.
DR   eggNOG; KOG0266; Eukaryota.
DR   HOGENOM; CLU_056876_0_0_1; -.
DR   InParanoid; Q6P1V3; -.
DR   OMA; CTIDAGE; -.
DR   OrthoDB; 805365at2759; -.
DR   PhylomeDB; Q6P1V3; -.
DR   TreeFam; TF329216; -.
DR   Reactome; R-XTR-8951664; Neddylation.
DR   Reactome; R-XTR-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000021353; Expressed in testis and 22 other tissues.
DR   ExpressionAtlas; Q6P1V3; differential.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF07525; SOCS_box; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF158235; SSF158235; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50225; SOCS; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..422
FT                   /note="WD repeat and SOCS box-containing protein 1"
FT                   /id="PRO_0000347228"
FT   REPEAT          124..165
FT                   /note="WD 1"
FT   REPEAT          168..208
FT                   /note="WD 2"
FT   REPEAT          212..251
FT                   /note="WD 3"
FT   REPEAT          254..293
FT                   /note="WD 4"
FT   REPEAT          309..346
FT                   /note="WD 5"
FT   DOMAIN          374..422
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
SQ   SEQUENCE   422 AA;  47496 MW;  C216C3482782359D CRC64;
     MASFPDFVNE NEIARSRTIG ELITPTSPFE QKYGRENWTV AFAPDGSYFA WSQGHRIVKL
     VPWSRCLKNF TACSTKNGVN LTNGRLSRQN SDLGQRNKPI EHTIDCGDIV WSLAFGSSVP
     EKQSRCVNIE WHRFKFGQDQ LLLATGLSNG RIKIWDVYTG KLLLNLMDHT EVVRDLTFAP
     DGSLILVSAS RDKTLRVWDL KDDGNMMKVL RGHQNWVYCC AFSPDSSMLC SVGAGKAVFL
     WDMDKYTMIR KLDGHYNDVV ACEFSPDGAL LATASYDTRV YVWDPHIGSI LFEFGHLFPP
     PTPIFAGGDN GRWVKSVSFS HDGVHIASLA DDNLVRFWRI DKSYPVEVAP LSKGLCCAFS
     TDGSVLAAGT QDGNAYFWST PKYVSSLQHL CRMAIRRVMN TNEVKKLPIP QKIMEFLTYQ
     TM