ID   WSB2_BOVIN              Reviewed;         406 AA.
AC   Q0V8J1;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=WD repeat and SOCS box-containing protein 2;
DE            Short=WSB-2;
GN   Name=WSB2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC       (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which
CC       mediates the ubiquitination and subsequent proteasomal degradation of
CC       target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin ligase
CC       complexes. {ECO:0000250}.
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DR   EMBL; BT026227; ABG67066.1; -; mRNA.
DR   RefSeq; NP_001068825.1; NM_001075357.1.
DR   AlphaFoldDB; Q0V8J1; -.
DR   SMR; Q0V8J1; -.
DR   STRING; 9913.ENSBTAP00000009395; -.
DR   PaxDb; Q0V8J1; -.
DR   PRIDE; Q0V8J1; -.
DR   GeneID; 508388; -.
DR   KEGG; bta:508388; -.
DR   CTD; 55884; -.
DR   eggNOG; KOG0266; Eukaryota.
DR   HOGENOM; CLU_056876_0_0_1; -.
DR   InParanoid; Q0V8J1; -.
DR   OrthoDB; 805365at2759; -.
DR   TreeFam; TF329216; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF07525; SOCS_box; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF158235; SSF158235; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50225; SOCS; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..406
FT                   /note="WD repeat and SOCS box-containing protein 2"
FT                   /id="PRO_0000253036"
FT   REPEAT          107..150
FT                   /note="WD 1"
FT   REPEAT          153..193
FT                   /note="WD 2"
FT   REPEAT          197..236
FT                   /note="WD 3"
FT   REPEAT          239..278
FT                   /note="WD 4"
FT   REPEAT          293..332
FT                   /note="WD 5"
FT   DOMAIN          358..406
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT   REGION          70..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..87
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   406 AA;  45520 MW;  A937C4FBB1E0B4AF CRC64;
     MLSPAPEEPL LLAELKPGRP HQFDWKSSCE TWSVAFSPDG SWFAWSQGHC IVKLIPWPLE
     EQFIPKGFEA KSRSSKNETK GRGSPKEKTL DCGQIVWGLA FSPWPSPPSK KLWARHHPQV
     PDVSCLILAT GLNDGQIKIW EVQTGLLLLN LSGHQDVVRD LSFTPSGSLI LVSASRDKTL
     RIWDLNKHGK QIQVLSGHLQ WVYCCSISPD CSMLCSAAGE KSVFLWSMRS YTLIRKLEGH
     QSSVVSCDFS PDSALLVTAS YDTNVIMWDP YTGERLRSLH HTQLNPPMDD SDVHISSLRS
     VCFSPEGLYL ATVADDRLLR IWALELKTPI AFAPMTNGLC CTFFPHGGVI ATGTRDGHVQ
     FWTAPRVLSS LKHLCRKALR SFLTTYQVLA LPIPKKMKEF LTYRTF