WSB2_MOUSE
ID WSB2_MOUSE Reviewed; 404 AA.
AC O54929; Q6GTI7; Q9R1M8;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=WD repeat and SOCS box-containing protein 2;
DE Short=WSB-2;
DE AltName: Full=SOCS box-containing WD protein SWiP-2;
GN Name=Wsb2; Synonyms=Swip2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Spleen;
RX PubMed=9419338; DOI=10.1073/pnas.95.1.114;
RA Hilton D.J., Richardson R.T., Alexander W.S., Viney E.M., Willson T.A.,
RA Sprigg N.S., Starr R., Nicholson S.E., Metcalf D., Nicola N.A.;
RT "Twenty proteins containing a C-terminal SOCS box form five structural
RT classes.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:114-119(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10354473; DOI=10.1016/s0925-4773(99)00014-3;
RA Vasiliauskas D., Hancock S., Stern C.D.;
RT "SWiP-1: novel SOCS box containing WD-protein regulated by signalling
RT centres and by Shh during development.";
RL Mech. Dev. 82:79-94(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Inner ear;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which
CC mediates the ubiquitination and subsequent proteasomal degradation of
CC target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin ligase
CC complexes. {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF033188; AAB96649.1; -; mRNA.
DR EMBL; AF072881; AAD28809.1; -; mRNA.
DR EMBL; AK157999; BAE34309.1; -; mRNA.
DR EMBL; CH466529; EDL19806.1; -; Genomic_DNA.
DR EMBL; BC055100; AAH55100.1; -; mRNA.
DR CCDS; CCDS19604.1; -.
DR RefSeq; NP_067514.2; NM_021539.4.
DR AlphaFoldDB; O54929; -.
DR SMR; O54929; -.
DR BioGRID; 208507; 9.
DR STRING; 10090.ENSMUSP00000031309; -.
DR iPTMnet; O54929; -.
DR PhosphoSitePlus; O54929; -.
DR MaxQB; O54929; -.
DR PaxDb; O54929; -.
DR PRIDE; O54929; -.
DR ProteomicsDB; 299698; -.
DR Antibodypedia; 31364; 98 antibodies from 26 providers.
DR DNASU; 59043; -.
DR Ensembl; ENSMUST00000031309; ENSMUSP00000031309; ENSMUSG00000029364.
DR GeneID; 59043; -.
DR KEGG; mmu:59043; -.
DR UCSC; uc008zfq.1; mouse.
DR CTD; 55884; -.
DR MGI; MGI:2144041; Wsb2.
DR VEuPathDB; HostDB:ENSMUSG00000029364; -.
DR eggNOG; KOG0266; Eukaryota.
DR GeneTree; ENSGT00890000139406; -.
DR HOGENOM; CLU_056876_0_0_1; -.
DR InParanoid; O54929; -.
DR OMA; PWPLEEH; -.
DR OrthoDB; 805365at2759; -.
DR TreeFam; TF329216; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 59043; 6 hits in 75 CRISPR screens.
DR ChiTaRS; Wsb2; mouse.
DR PRO; PR:O54929; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; O54929; protein.
DR Bgee; ENSMUSG00000029364; Expressed in barrel cortex and 267 other tissues.
DR ExpressionAtlas; O54929; baseline and differential.
DR Genevisible; O54929; MM.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF07525; SOCS_box; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF158235; SSF158235; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50225; SOCS; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT CHAIN 1..404
FT /note="WD repeat and SOCS box-containing protein 2"
FT /id="PRO_0000051461"
FT REPEAT 105..148
FT /note="WD 1"
FT REPEAT 151..191
FT /note="WD 2"
FT REPEAT 195..234
FT /note="WD 3"
FT REPEAT 237..276
FT /note="WD 4"
FT REPEAT 291..330
FT /note="WD 5"
FT DOMAIN 356..404
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT CONFLICT 272
FT /note="E -> A (in Ref. 1; AAB96649)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 404 AA; 45261 MW; 78F66FE09910635A CRC64;
MEAGEEPLLL AELKPGRPHQ FDWKSSCETW SVAFSPDGSW FAWSQGHCVV KLVPWPLEEQ
FIPKGFEAKS RSSKNDPKGR GSLKEKTLDC GQIVWGLAFS PWPSPPSRKL WARHHPQAPD
VSCLILATGL NDGQIKIWEV QTGLLLLNLS GHQDVVRDLS FTPSGSLILV SASRDKTLRI
WDLNKHGKQI QVLSGHLQWV YCCSISPDCS MLCSAAGEKS VFLWSMRSYT LIRKLEGHQS
SVVSCDFSPD SALLVTASYD TSVIMWDPYT GERLRSLHHT QLEPTMDDSD VHMSSLRSVC
FSPEGLYLAT VADDRLLRIW ALELKAPVAF APMTNGLCCT FFPHGGIIAT GTRDGHVQFW
TAPRVLSSLK HLCRKALRSF LTTYQVLALP IPKKMKEFLT YRTF
