WSC3_YEAST
ID WSC3_YEAST Reviewed; 556 AA.
AC Q12215; D6W1W1; Q2VQX5;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Cell wall integrity and stress response component 3;
DE Flags: Precursor;
GN Name=WSC3; OrderedLocusNames=YOL105C; ORFNames=HRE556;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7502582; DOI=10.1002/yea.320111108;
RA Vandenbol M., Durand P., Portetelle D., Hilger F.;
RT "Sequence analysis of a 44 kb DNA fragment of yeast chromosome XV including
RT the Ty1-H3 retrotransposon, the suf1(+) frameshift suppressor gene for
RT tRNA-Gly, the yeast transfer RNA-Thr-1a and a delta element.";
RL Yeast 11:1069-1075(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-80.
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=15905473; DOI=10.1093/nar/gki583;
RA Zhang Z., Dietrich F.S.;
RT "Mapping of transcription start sites in Saccharomyces cerevisiae using 5'
RT SAGE.";
RL Nucleic Acids Res. 33:2838-2851(2005).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
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DR EMBL; Z48149; CAA88155.1; -; Genomic_DNA.
DR EMBL; Z74847; CAA99123.1; -; Genomic_DNA.
DR EMBL; AY899243; AAX83928.1; -; mRNA.
DR EMBL; BK006948; DAA10677.1; -; Genomic_DNA.
DR PIR; S51892; S51892.
DR RefSeq; NP_014536.1; NM_001183359.1.
DR AlphaFoldDB; Q12215; -.
DR SMR; Q12215; -.
DR BioGRID; 34296; 55.
DR DIP; DIP-1748N; -.
DR IntAct; Q12215; 11.
DR MINT; Q12215; -.
DR STRING; 4932.YOL105C; -.
DR iPTMnet; Q12215; -.
DR PaxDb; Q12215; -.
DR EnsemblFungi; YOL105C_mRNA; YOL105C; YOL105C.
DR GeneID; 854046; -.
DR KEGG; sce:YOL105C; -.
DR SGD; S000005465; WSC3.
DR VEuPathDB; FungiDB:YOL105C; -.
DR eggNOG; KOG4157; Eukaryota.
DR GeneTree; ENSGT00940000176584; -.
DR HOGENOM; CLU_024893_1_0_1; -.
DR InParanoid; Q12215; -.
DR OMA; MERITFS; -.
DR BioCyc; YEAST:G3O-33503-MON; -.
DR PRO; PR:Q12215; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q12215; protein.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043332; C:mating projection tip; HDA:SGD.
DR GO; GO:0005886; C:plasma membrane; IDA:SGD.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IMP:SGD.
DR GO; GO:0030242; P:autophagy of peroxisome; IMP:SGD.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0009408; P:response to heat; IMP:SGD.
DR GO; GO:0007266; P:Rho protein signal transduction; IMP:SGD.
DR InterPro; IPR002889; WSC_carb-bd.
DR Pfam; PF01822; WSC; 1.
DR SMART; SM00321; WSC; 1.
DR PROSITE; PS51212; WSC; 1.
PE 1: Evidence at protein level;
KW Cell wall biogenesis/degradation; Glycoprotein; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..38
FT /evidence="ECO:0000255"
FT CHAIN 39..556
FT /note="Cell wall integrity and stress response component 3"
FT /id="PRO_0000041485"
FT TOPO_DOM 39..384
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 406..556
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 39..132
FT /note="WSC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00558"
FT REGION 142..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 367
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 370
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 556 AA; 58230 MW; DD37E277180001DA CRC64;
MERVWFAKLT NKGTIKIGYI SFILLSLLCQ SLIGLVNADF NYEGCYSAAD IQSAGLSLKN
SYIYQSVSYC QNQCPESAVV ALFNGSDCYC GNSVSFLTSL TKSTDSNCGT KCSGWPYQMC
GGSSYMNVYV NAETFVSSVE SSSSKEGSST SYMPSTTSSL SSAQISSTTR RTSTDMKSSE
MIATTVSTTS TTSSSTSSTT SSTTSSTTSS TTSSTTSSST SSTTSSTTSS TTSSTTSSTT
SSTTSSTTSS TTSSTTSIFS VTSSSSSITL SSSEHTTVDS RTSSPSSTLV PVSSSSSTLS
TPKVTSMTPS TSSTIPIVTS VELVTSVVTK AIVSTSDQHQ ETIFVTRTSV VERSSEVATA
TAAASNNRSN STSKQRLSGG AIAGIVIGVV FGVIFIILIL LFLIWRRRKS HDQLDLEETK
HYQPYSFGDE DANPIGPPPS SGTTNWMRHS RGNTAGSIGT SNMYGFSMSN GANYSSPSSN
TSGSIINNLA GLQDATVQKQ NLPSTVFEEA NTLNSANERF SANSLPDMMM SGPLQVVNPD
NPDNPELSST VSHNRA
