WSC4_YEAST
ID WSC4_YEAST Reviewed; 605 AA.
AC P38739; D3DKU0;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Cell wall integrity and stress response component 4;
DE Flags: Precursor;
GN Name=WSC4; OrderedLocusNames=YHL028W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091229; DOI=10.1126/science.8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA Waterston R., Wilson R., Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U11583; AAB65040.1; -; Genomic_DNA.
DR EMBL; BK006934; DAA06657.1; -; Genomic_DNA.
DR PIR; S48940; S48940.
DR RefSeq; NP_011835.1; NM_001179108.1.
DR AlphaFoldDB; P38739; -.
DR SMR; P38739; -.
DR BioGRID; 36394; 32.
DR IntAct; P38739; 3.
DR STRING; 4932.YHL028W; -.
DR iPTMnet; P38739; -.
DR MaxQB; P38739; -.
DR PaxDb; P38739; -.
DR PRIDE; P38739; -.
DR EnsemblFungi; YHL028W_mRNA; YHL028W; YHL028W.
DR GeneID; 856357; -.
DR KEGG; sce:YHL028W; -.
DR SGD; S000001020; WSC4.
DR VEuPathDB; FungiDB:YHL028W; -.
DR eggNOG; KOG4157; Eukaryota.
DR HOGENOM; CLU_024893_2_1_1; -.
DR InParanoid; P38739; -.
DR OMA; GYWDSPG; -.
DR BioCyc; YEAST:G3O-31048-MON; -.
DR PRO; PR:P38739; -.
DR Proteomes; UP000002311; Chromosome VIII.
DR RNAct; P38739; protein.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IMP:SGD.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0045047; P:protein targeting to ER; IMP:SGD.
DR GO; GO:0006612; P:protein targeting to membrane; IMP:SGD.
DR GO; GO:0009408; P:response to heat; IGI:SGD.
DR InterPro; IPR002889; WSC_carb-bd.
DR SMART; SM00321; WSC; 1.
DR PROSITE; PS51212; WSC; 1.
PE 3: Inferred from homology;
KW Cell wall biogenesis/degradation; Glycoprotein; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..605
FT /note="Cell wall integrity and stress response component 4"
FT /id="PRO_0000041486"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 27..110
FT /note="WSC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00558"
FT REGION 151..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 340
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 386
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 389
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 398
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 479
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 553
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 583
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 605 AA; 63808 MW; C9DF8CBAA9553811 CRC64;
MQTSMVSAKV SIWLVCSVIC SSLVRATQSV CSSQNTATTD GVRNQFQSNG WCSNNCAGHQ
FAIVQGFMCW CSDSEPSTQT SVGDCSGTCP GYGYEDCGNA DKDLFGYIYL GQTPLSSVQS
VETSTESSVY VSSSSITSSS STSIVDTTTI SPTLTSTSTT PLTTASTSTT PSTDITSALP
TTTSTKLSTS IPTSTTSSTS TTTSTSSSTS TTVSVTSSTS TTTSTTSSTL ISTSTSSSSS
STPTTTSSAP ISTSTTSSTS TSTSTTSPTS SSAPTSSSNT TPTSTTFTTT SPSTAPSSTT
VTYTSTTASP ITSTITSVNL QTSLKYSVIT VTSVHTMDTN ISEITSRYLT MKKVITQIYS
STLGATPTSA VATTSASVGG RITNNNNSNT TNSNTPTNKS TEKKGYWDSP GKIAATFVVV
GVVCLVIICI LIYLIHHYRT RPARKAQDFE NEYQSKFYQS KYPNEVTTTT LHTPSPSSNS
TFSTPRLIYT DEKGQIMSES PSPRQSTYSL TAGSPPNDPS TLASPFHDPI LPRRTSTFLH
SPIQKQHEKM ESNVTLGEDT VLVDQRLDPS KMLNTLANDD ATNHSTISLS DNVDYSRRVL
RLMNE
