ID   WSCA_ASPFU              Reviewed;         228 AA.
AC   Q4WZG1;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Woronin body membrane protein wscA {ECO:0000303|PubMed:23869404};
GN   Name=wscA {ECO:0000303|PubMed:23869404}; ORFNames=AFUA_2G17080;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
RN   [2]
RP   FUNCTION.
RX   PubMed=23869404; DOI=10.1111/mmi.12316;
RA   Beck J., Echtenacher B., Ebel F.;
RT   "Woronin bodies, their impact on stress resistance and virulence of the
RT   pathogenic mould Aspergillus fumigatus and their anchoring at the septal
RT   pore of filamentous Ascomycota.";
RL   Mol. Microbiol. 89:857-871(2013).
CC   -!- FUNCTION: Woronin sorting complex protein involved in both Woronin
CC       bodies (WB) formation and inherence (PubMed:23869404). Localizes to
CC       large peroxisome membranes where it self-assembles into detergent-
CC       resistant oligomers that envelop hex-1 assemblies, producing
CC       asymmetrical nascent WBs (By similarity). These structures are then
CC       delivered to the cell cortex, which permits partitioning of the nascent
CC       WB and WB inheritance (By similarity). {ECO:0000250|UniProtKB:U9W802,
CC       ECO:0000269|PubMed:23869404}.
CC   -!- SUBUNIT: Self-assembles into detergent-resistant oligomers and forms a
CC       complex with hexA assemblies. {ECO:0000250|UniProtKB:U9W802}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC       {ECO:0000250|UniProtKB:U9W802}; Multi-pass membrane protein
CC       {ECO:0000255}. Cell septum {ECO:0000250|UniProtKB:U9W802}.
CC       Note=Localizes to nascent and mature Woronin bodies, fungal-specific
CC       organelles that plug the septal pore in case of physical damage.
CC       {ECO:0000250|UniProtKB:U9W802}.
CC   -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC       {ECO:0000305}.
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DR   EMBL; AAHF01000001; EAL94004.1; -; Genomic_DNA.
DR   RefSeq; XP_756042.1; XM_750949.1.
DR   STRING; 746128.CADAFUBP00003209; -.
DR   EnsemblFungi; EAL94004; EAL94004; AFUA_2G17080.
DR   GeneID; 3513521; -.
DR   KEGG; afm:AFUA_2G17080; -.
DR   eggNOG; KOG1944; Eukaryota.
DR   HOGENOM; CLU_066033_1_0_1; -.
DR   InParanoid; Q4WZG1; -.
DR   OMA; KMAIYGA; -.
DR   OrthoDB; 1482554at2759; -.
DR   Proteomes; UP000002530; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0140266; C:Woronin body; ISS:GO_Central.
DR   InterPro; IPR007248; Mpv17_PMP22.
DR   PANTHER; PTHR11266; PTHR11266; 1.
DR   Pfam; PF04117; Mpv17_PMP22; 1.
PE   3: Inferred from homology;
KW   Membrane; Peroxisome; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..228
FT                   /note="Woronin body membrane protein wscA"
FT                   /id="PRO_0000455968"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   228 AA;  25314 MW;  05D991CC3DD057B7 CRC64;
     MSVKFQEEAT RSIRADTKEL AHKVGERLTG GNAQTGYLAL YLRQLQSNPL RTKMLTSGLL
     SGLQEVLASW IANDVSKHGH YFSARVPKMT LYGMFISAPL GHLLVGILQK VFAGRTSLKA
     KILQILASNL IVSPIQNAVY LMSMAIIAGA RTLHQVRATV KAGFMPVMKV SWITSPLALA
     FAQKFLPEHT WVPFFNIIGF FIGTYVNTHT KKKRLEALRK VQSTSRTK